Search Results - "Ashkar, A. A."

The Dual Nature of Type I and Type II Interferons by Lee, Amanda J, Ashkar, Ali A

“…Type I and type II interferons (IFN) are central to both combating virus infection and modulating the antiviral immune response. Indeed, an absence of either…”
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What Defines NK Cell Functional Fate: Phenotype or Metabolism? by Poznanski, Sophie M, Ashkar, Ali A

“…NK cells are capable of an array of functions that range widely from their classic anti-tumor and anti-viral cytotoxic effector functions, to their critical…”
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Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment by Poznanski, Sophie M, Singh, Kanwaldeep, Ritchie, Tyrah M, Aguiar, Jennifer A, Fan, Isabella Y, Portillo, Ana L, Rojas, Eduardo A, Vahedi, Fatemeh, El-Sayes, Abdullah, Xing, Sansi, Butcher, Martin, Lu, Yu, Doxey, Andrew C, Schertzer, Jonathan D, Hirte, Hal W, Ashkar, Ali A

“…NK cells are central to anti-tumor immunity and recently showed efficacy for treating hematologic malignancies. However, their dysfunction in the hostile tumor…”
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The influence of macrophages and the tumor microenvironment on natural killer cells by Krneta, T, Gillgrass, A, Ashkar, A A

“…Numerous reviews in the field of NK cell biology dictate the pivotal role that NK cells play in tumor rejection. Although these cell types were originally…”
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Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus by He, Wenqian, Tan, Gene S., Mullarkey, Caitlin E., Lee, Amanda J., Lam, Mannie Man Wai, Krammer, Florian, Henry, Carole, Wilson, Patrick C., Ashkar, Ali A., Palese, Peter, Miller, Matthew S.

“…The generation of strain-specific neutralizing antibodies against influenza A virus is known to confer potent protection against homologous infections. The…”
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Length of dsRNA (poly I:C) drives distinct innate immune responses, depending on the cell type by Mian, M. Firoz, Ahmed, Amna N., Rad, Mehrnaz, Babaian, Artem, Bowdish, Dawn, Ashkar, Ali A.

“…Using short or long Poly I:C to induce optimal innate immune responses or adjuvant effects depends on the target cell types. Poly I:C, a synthetic dsRNA…”
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The breast tumor microenvironment alters the phenotype and function of natural killer cells by Krneta, Tamara, Gillgrass, Amy, Chew, Marianne, Ashkar, Ali A.

“…Natural killer （NK） ceils are innate immune cells with the ability to identify and eliminate transformed cells. However, within tumors, many studies have…”
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AHR signaling is induced by infection with coronaviruses by Giovannoni, Federico, Li, Zhaorong, Remes-Lenicov, Federico, Dávola, María E., Elizalde, Mercedes, Paletta, Ana, Ashkar, Ali A., Mossman, Karen L., Dugour, Andrea V., Figueroa, Juan M., Barquero, Andrea A., Ceballos, Ana, Garcia, Cybele C., Quintana, Francisco J.

“…Coronavirus infection in humans is usually associated to respiratory tract illnesses, ranging in severity from mild to life-threatening respiratory failure…”
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Interferon Gamma in Successful Pregnancies by Murphy, Shawn P, Tayade, Chandrakant, Ashkar, Ali A, Hatta, Kota, Zhang, Jianhong, Croy, B. Anne

“…Interferon gamma (IFNG) is a proinflammatory cytokine secreted in the uterus during early pregnancy. It is abundantly produced by uterine natural killer cells…”
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TLR2 Plays a Pivotal Role in Mediating Mucosal Serotonin Production in the Gut by Wang, Huaqing, Kwon, Yun Han, Dewan, Varun, Vahedi, Fatemeh, Syed, Saad, Fontes, Michelle E, Ashkar, Ali A, Surette, Michael G, Khan, Waliul I

“…Serotonin (5-hydroxytryptamine [5-HT]) is a key enteric signaling molecule that mediates various physiological processes in the gut. Enterochromaffin (EC)…”
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Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection by Lee, Amanda J, Chen, Branson, Chew, Marianne V, Barra, Nicole G, Shenouda, Mira M, Nham, Tina, van Rooijen, Nico, Jordana, Manel, Mossman, Karen L, Schreiber, Robert D, Mack, Matthias, Ashkar, Ali A

“…The requirement of type I interferon (IFN) for natural killer (NK) cell activation in response to viral infection is known, but the underlying mechanism…”
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Bystander activated CD8+ T cells mediate neuropathology during viral infection via antigen-independent cytotoxicity by Balint, Elizabeth, Feng, Emily, Giles, Elizabeth C., Ritchie, Tyrah M., Qian, Alexander S., Vahedi, Fatemeh, Montemarano, Amelia, Portillo, Ana L., Monteiro, Jonathan K., Trigatti, Bernardo L., Ashkar, Ali A.

“…Although many viral infections are linked to the development of neurological disorders, the mechanism governing virus-induced neuropathology remains poorly…”
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Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours by Shenouda, Mira M, Gillgrass, Amy, Nham, Tina, Hogg, Richard, Lee, Amanda J, Chew, Marianne V, Shafaei, Mahsa, Aarts, Craig, Lee, Dean A, Hassell, John, Bane, Anita, Dhesy-Thind, Sukhbinder, Ashkar, Ali A

“…Natural killer (NK) cells play a critical role in cancer immunosurveillance. Recent developments in NK cell ex-vivo expansion makes it possible to generate…”
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Influenza Infection Leads to Increased Susceptibility to Subsequent Bacterial Superinfection by Impairing NK Cell Responses in the Lung by Small, Cherrie-Lee, Shaler, Christopher R, McCormick, Sarah, Jeyanathan, Mangalakumari, Damjanovic, Daniela, Brown, Earl G, Arck, Petra, Jordana, Manel, Kaushic, Charu, Ashkar, Ali A, Xing, Zhou

“…Influenza viral infection is well-known to predispose to subsequent bacterial superinfection in the lung but the mechanisms have remained poorly defined. We…”
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Interleukin-15 and Natural Killer and NKT Cells Play a Critical Role in Innate Protection against Genital Herpes Simplex Virus Type 2 Infection by Ashkar, Ali A, Rosenthal, Kenneth L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Immunoregulatory Functions of Interferons During Genital HSV-2 Infection by Feng, Emily, Balint, Elizabeth, Vahedi, Fatemah, Ashkar, Ali A

“…Herpes simplex virus type 2 (HSV-2) infection is one of the most prevalent sexually transmitted infections that disproportionately impacts women worldwide…”
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Aging and Interferons: Impacts on Inflammation and Viral Disease Outcomes by Feng, Emily, Balint, Elizabeth, Poznanski, Sophie M, Ashkar, Ali A, Loeb, Mark

“…As highlighted by the COVID-19 global pandemic, elderly individuals comprise the majority of cases of severe viral infection outcomes and death. A combined…”
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Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke by Mian, M. Firoz, Lauzon, Nicole M., Stämpfli, Martin R., Mossman, Karen L., Ashkar, Ali A.

“…NK cells play essential roles in innate host defense against microbial infections and tumor surveillance. Although evidence suggests that smoking has adverse…”
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From Mosquito Bites to Sexual Transmission: Evaluating Mouse Models of Zika Virus Infection by Balint, Elizabeth, Montemarano, Amelia, Feng, Emily, Ashkar, Ali A

“…Following the recent outbreak of Zika virus (ZIKV) infections in Latin America, ZIKV has emerged as a global health threat due to its ability to induce…”
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S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3 by Wang, Fuan, Alain, Tommy, Szretter, Kristy J, Stephenson, Kyle, Pol, Jonathan G, Atherton, Matthew J, Hoang, Huy-Dung, Fonseca, Bruno D, Zakaria, Chadi, Chen, Lan, Rangwala, Zainab, Hesch, Adam, Chan, Eva Sin Yan, Tuinman, Carly, Suthar, Mehul S, Jiang, Zhaozhao, Ashkar, Ali A, Thomas, George, Kozma, Sara C, Gale, Michael, Fitzgerald, Katherine A, Diamond, Michael S, Mossman, Karen, Sonenberg, Nahum, Wan, Yonghong, Lichty, Brian D

“…Activation of the transcription factor IRF3 is a key event in antiviral responses. Lichty and colleagues show that recruitment of the mTOR downstream effector…”
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