Search Results - "Ashino, Shigeru"

Less airway inflammation and goblet cell metaplasia in an IL-33-induced asthma model of leptin-deficient obese mice by Kurokawa, Atsushi, Kondo, Mitsuko, Arimura, Ken, Ashino, Shigeru, Tagaya, Etsuko

“…Abstract Background Obesity-associated asthma is a phenotype of severe asthma. Late-onset, non-eosinophilic and female-dominant phenotype is highly symptomatic…”
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Mesenchymal Stem Cells Recruit CCR2 + Monocytes To Suppress Allergic Airway Inflammation by Takeda, Katsuyuki, Webb, Tracy L, Ning, Fangkun, Shiraishi, Yoshiki, Regan, Daniel P, Chow, Lyndah, Smith, Mia J, Ashino, Shigeru, Guth, Amanda M, Hopkins, Sophie, Gelfand, Erwin W, Dow, Steven

“…Mesenchymal stem cells (MSC) exert immune modulatory properties and previous studies demonstrated suppressive effects of MSC treatment in animal models of…”
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Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge by Takeda, Katsuyuki, MD, PhD, Shiraishi, Yoshiki, PhD, Ashino, Shigeru, PhD, Han, Junyan, PhD, Jia, Yi, MD, PhD, Wang, Meiqin, MD, PhD, Lee, Nancy A., PhD, Lee, James J., PhD, Gelfand, Erwin W., MD

“…Background Eosinophils accumulate at the site of allergic inflammation and are critical effector cells in allergic diseases. Recent studies have also suggested…”
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Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses by Ashino, Shigeru, Takeda, Katsuyuki, Li, Hui, Taylor, Vanessa, Joetham, Anthony, Pine, Polly R., Gelfand, Erwin W.

“…Janus kinases (JAKs) are regulators of signaling through cytokine receptors. The importance of JAK1/3 signaling on TH2 differentiation and development of lung…”
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Expression and activation of the steroidogenic enzyme CYP11A1 is associated with IL-13 production in T cells from peanut allergic children by Wang, Meiqin, Strand, Matthew J, Lanser, Bruce J, Santos, Carah, Bendelja, Kreso, Fish, Jennifer, Esterl, Elizabeth A, Ashino, Shigeru, Abbott, Jordan K, Knight, Vijaya, Gelfand, Erwin W

“…Activation of the steroidogenic enzyme CYP11A1 was shown to be necessary for the development of peanut-induced intestinal anaphylaxis and IL-13 production in…”
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Effect of Cholecalciferol in Food Allergy Mouse Model Is Associated with Decrease of CD69+ CD4+ T Cells by ZAIM, Ece, ASHINO, Shigeru, OSAKA, Toshifumi, YANAGISAWA, Naoko, YAGI, Junji

“…Food allergy prevalence is increasing all over the world. Recent epidemiologic studies have shown the link between vitamin D3 insufficiency and food allergy…”
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Activation of p70S6 Kinase‐1 in Mesenchymal Stem Cells Is Essential to Lung Tissue Repair by Takeda, Katsuyuki, Ning, Fangkun, Domenico, Joanne, Okamoto, Masakazu, Ashino, Shigeru, Kim, Sang‐Ha, Jeong, Yi Yeong, Shiraishi, Yoshiki, Terada, Naohiro, Sutherland, Everett Rand, Gelfand, Erwin W.

“…All‐trans retinoic acid (ATRA) or mesenchymal stem cells (MSCs) have been shown to promote lung tissue regeneration in animal models of emphysema. However, the…”
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Combination immunotherapy with radiation and CpG‐based tumor vaccination for the eradication of radio‐ and immuno‐resistant lung carcinoma cells by Chamoto, Kenji, Takeshima, Tsuguhide, Wakita, Daiko, Ohkuri, Takayuki, Ashino, Shigeru, Omatsu, Tokuhiko, Shirato, Hiroki, Kitamura, Hidemitsu, Togashi, Yuji, Nishimura, Takashi

“…Unmethylated cytosine‐phosphorothioate‐guanine containing oligodeoxynucleotides (CpG‐ODN) is known as a ligand of toll‐like receptor 9 (TLR9), which…”
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Blocking of IL-6 signaling pathway prevents CD4+ T cell-mediated colitis in a Th17-independent manner by Noguchi, Daisuke, Wakita, Daiko, Tajima, Masaki, Ashino, Shigeru, Iwakura, Yoichiro, Zhang, Yue, Chamoto, Kenji, Kitamura, Hidemitsu, Nishimura, Takashi

“…Naive CD4+ T cells rapidly proliferate to generate effector cells after encountering an antigen and small numbers survive as memory T cells in preparation for…”
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A Th17-polarized cell population that has infiltrated the lung requires cells that convert to IFN-γ production in order to induce airway hyperresponsiveness by Ashino, Shigeru, Wakita, Daiko, Shiohama, Yasuo, Iwakura, Yoichiro, Chamoto, Kenji, Ohkuri, Takayuki, Kitamura, Hidemitsu, Nishimura, Takashi

“…Adoptive cell transfer of an ovalbumin (OVA)-specific Th17-polarized cell population from transgenic DO11.10 mice into BALB/c mice followed by OVA inhalation…”
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CpG-ODN inhibits airway inflammation at effector phase through down-regulation of antigen-specific Th2-cell migration into lung by Ashino, Shigeru, Wakita, Daiko, Zhang, Yue, Chamoto, Kenji, Kitamura, Hidemitsu, Nishimura, Takashi

“…Allergic airway inflammation is one of the most typical characteristic features of bronchial asthma. Th2 cells, which produce IL-4, IL-5 and IL-13, are well…”
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Inhibition of Pim1 Kinase Attenuates Respiratory Syncytial Virus (RSV) Re-Infection-Induced Enhanced Airway Hyperresponsiveness (AHR) and Inflammation by Han, Junyan, PhD, Zeng, Wanjiang, MD, Wang, Meiqin, MD, PhD, Takeda, Katsuyuki, MD, Ashino, Shigeru, PhD, Jia, Yi, PhD, Shin, Yoo Seob, MD, PhD, Gelfand, Erwin W., MD

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STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation by Hoshino, Akihiko, Tsuji, Takemasa, Matsuzaki, Junko, Jinushi, Takafumi, Ashino, Shigeru, Teramura, Takashi, Chamoto, Kenji, Tanaka, Yoshitaka, Asakura, Yumiko, Sakurai, Takanobu, Mita, Yasuo, Takaoka, Akiko, Nakaike, Shiro, Takeshima, Tsuguhide, Ikeda, Hiroaki, Nishimura, Takashi

“…When wild-type BALB/c mice were transferred with OVA-specific Th2 cells followed by OVA inhalation, a severe eosinophilia, mucus hypersecretion and airway…”
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CpG-ODN inhibits airway inflammation at effector phase through down-regulation of antigen-specific T[sub]h2-cell migration into lung by Ashino, Shigeru, Wakita, Daiko, Zhang, Yue, Chamoto, Kenji, Kitamura, Hidemitsu, Nishimura, Takashi

“…Allergic airway inflammation is one of the most typical characteristic features of bronchial asthma. T[sub]h2 cells, which produce IL-4, IL-5 and IL-13, are…”
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Blocking of IL-6 signaling pathway prevents CD4[sup]+ T cell-mediated colitis in a T[sub]h17-independent manner by Noguchi, Daisuke, Wakita, Daiko, Tajima, Masaki, Ashino, Shigeru, Iwakura, Yoichiro, Zhang, Yue, Chamoto, Kenji, Kitamura, Hidemitsu, Nishimura, Takashi

“…Naive CD4+ T cells rapidly proliferate to generate effector cells after encountering an antigen and small numbers survive as memory T cells in preparation for…”
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Critical role of IFN-alpha/beta and IFN-gamma in the regulation of airway inflammation by Ashino, Shigeru, Nishimura, Takashi

“…Immune balance, which is controlled by IFN-gamma-producing Th1 cells and IL-4-producing Th2 cells, plays a critical role in the regulation of airway…”
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Double But Not Single-Stranded RNA Exacerbates Allergen-Induced Airway Hyperresponsiveness and Airway Inflammation by Ashino, Shigeru, Takeda, Katsuyuki, Kitamura, Hidemitsu, Kurokawa, Atsushi, Akaba, Tomohiro, Kondo, Mitsuko, Takeyama, Kiyoshi, Tagaya, Etsuko, Yanagisawa, Naoko, Gelfand, Erwin

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Inhibition of Pim1 kinase prevents peanut allergy by enhancing Runx3 expression and suppressing T(H)2 and T(H)17 T-cell differentiation by Wang, Meiqin, Okamoto, Masakazu, Domenico, Joanne, Han, Junyan, Ashino, Shigeru, Shin, Yoo Seob, Gelfand, Erwin W

“…The provirus integration site for Moloney murine leukemia virus (Pim) 1 kinase is an oncogenic serine/threonine kinase implicated in cytokine-induced cell…”
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IFN‐γ elevates airway hyper‐responsiveness via up‐regulation of neurokinin A/neurokinin‐2 receptor signaling in a severe asthma model by Kobayashi, Minoru, Ashino, Shigeru, Shiohama, Yasuo, Wakita, Daiko, Kitamura, Hidemitsu, Nishimura, Takashi

“…The adoptive transfer of OVA‐specific Th1 cells into WT mice followed by OVA inhalation induces a significant elevation of airway hyper‐responsiveness (AHR)…”
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Blockade of JAK1/3 signaling with a selective inhibitor, R256, attenuates Th2 differentiation and development of allergen-induced airway hyperresponsiveness (AHR) and airway inflammation (P6047) by Ashino, Shigeru, Takeda, Katsuyuki, Pine, Polly, Gelfand, Erwin

“…Abstract JAK are major downstream regulators of signaling through cytokine receptors, activating STAT. Effective targeting of the Th2-associated JAK-STAT…”
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