Search Results - "Ashford, Michael LJ"

Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation by Mirshamsi, Shirin, Laidlaw, Hilary A, Ning, Ke, Anderson, Erin, Burgess, Laura A, Gray, Alexander, Sutherland, Calum, Ashford, Michael L J

“…Leptin and insulin are long-term regulators of body weight. They act in hypothalamic centres to modulate the function of specific neuronal subtypes, by…”
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Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion by McNeilly, Alison D., Yianakas, Adonis, Gallagher, Jennifer G., Tarlton, Jamie, Ashford, Michael LJ, McCrimmon, Rory J.

“…IL-6 is an important contributor to glucose and energy homeostasis through changes in whole-body glucose disposal, insulin sensitivity, food intake and energy…”
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AMYLOID-BETA 40 ADVERSELY INFLUENCES LARGE ARTERY STIFFNESS AND CUTANEOUS MICROVASCULAR FUNCTION IN OLDER ADULTS WITH DIVERSE CARDIOVASCULAR RISK by Aizawa, Kunihiko, Casanova, Francesco, Gooding, Kim M, Gates, Phillip E, Strain, W David, Shore, Angela C, Tuharska, Zofia, Meakin, Paul J, Ashford, Michael Lj, Khan, Faisel

“…Objective: Amyloid-beta (Aβ) peptides are considered to play a prominent role in Alzheimer's disease, but emerging experimental and clinical observations link…”
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Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 by Bell, Karen F.S., Al-Mubarak, Bashayer, Martel, Marc-André, McKay, Sean, Wheelan, Nicola, Hasel, Philip, Márkus, Nóra M., Baxter, Paul, Deighton, Ruth F., Serio, Andrea, Bilican, Bilada, Chowdhry, Sudhir, Meakin, Paul J., Ashford, Michael L.J., Wyllie, David J.A., Scannevin, Robert H., Chandran, Siddharthan, Hayes, John D., Hardingham, Giles E.

“…Forebrain neurons have weak intrinsic antioxidant defences compared with astrocytes, but the molecular basis and purpose of this is poorly understood. We show…”
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Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction by Meakin, Paul J, Coull, Bethany M, Tuharska, Zofia, McCaffery, Christopher, Akoumianakis, Ioannis, Antoniades, Charalambos, Brown, Jane, Griffin, Kathryn J, Platt, Fiona, Ozber, Claire H, Yuldasheva, Nadira Y, Makava, Natallia, Skromna, Anna, Prescott, Alan, McNeilly, Alison D, Siddiqui, Moneeza, Palmer, Colin Na, Khan, Faisel, Ashford, Michael Lj

“…Diabetes, obesity, and Alzheimer's disease (AD) are associated with vascular complications and impaired nitric oxide (NO) production. Furthermore, increased…”
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Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling by Reilly, Louise, Howie, Jacqueline, Wypijewski, Krzysztof, Ashford, Michael L. J., Hilgemann, Donald W., Fuller, William

“…ABSTRACT The electrogenic Na/Ca exchanger (NCX) mediates bidirectional Ca movements that are highly sensitive to changes of Na gradients in many cells. NCX1 is…”
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Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes by McNeilly, Alison D, Gallagher, Jennifer R, Dinkova-Kostova, Albena T, Hayes, John D, Sharkey, John, Ashford, Michael L J, McCrimmon, Rory J

“…It remains uncertain whether recurrent nonsevere hypoglycemia (Hypo) results in long-term cognitive impairment in type 1 diabetes (T1D). This study tested the…”
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High-Intensity Exercise as a Dishabituating Stimulus Restores Counterregulatory Responses in Recurrently Hypoglycemic Rodents by McNeilly, Alison D, Gallagher, Jennifer R, Huang, Jeffrey T-J, Ashford, Michael L J, McCrimmon, Rory J

“…Hypoglycemia is a major adverse effect of insulin therapy for people with type 1 diabetes (T1D). Profound defects in the normal counterregulatory response to…”
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Identification of Caveolar Resident Proteins in Ventricular Myocytes Using a Quantitative Proteomic Approach: Dynamic Changes in Caveolar Composition Following Adrenoceptor Activation[S] by Wypijewski, Krzysztof J., Tinti, Michele, Chen, Wenzhang, Lamont, Douglas, Ashford, MichaelL.J., Calaghan, Sarah C., Fuller, William

“…The lipid raft concept proposes that membrane environments enriched in cholesterol and sphingolipids cluster certain proteins and form platforms to integrate…”
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A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells by Ning, Ke, Miller, Lisa C, Laidlaw, Hilary A, Burgess, Laura A, Perera, Nevin M, Downes, C Peter, Leslie, Nick R, Ashford, Michael LJ

“…In obesity and diabetes, the ability of hypothalamic neurons to sense and transduce changes in leptin and insulin levels is compromised. The effects of both…”
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Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances by Smith, Mark A., Hisadome, Kazunari, Al‐Qassab, Hind, Heffron, Helen, Withers, Dominic J., Ashford, Michael L. J.

“…The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved…”
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Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation: e0138872 by Meakin, Paul J, Morrison, Vicky L, Sneddon, Claire C, Savinko, Terhi, Uotila, Liisa, Jalicy, Susan M, Gabriel, Jennie L, Kang, Li, Ashford, Michael LJ, Fagerholm, Susanna C

“…Beta2-integrins are important in leukocyte trafficking and function, and are regulated through the binding of cytoplasmic proteins, such as kindlin-3, to their…”
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Potassium channels in the human myometrium by Khan, Raheela N., Matharoo-Ball, Balwir, Arulkumaran, Sabaratnam, Ashford, Michael L. J.

“…The contractility of the human uterus is under the fine control of a variety of interacting bioactive agents. During labour, the excitability of the uterus is…”
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A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic [beta]-cells by Ke Ning, Miller, Lisa C, Laidlaw, Hilary A, Burgess, Laura A, Perera, Nevin M, Downes, C Peter, Leslie, Nick R, Ashford, Michael LJ

“…In obesity and diabetes, the ability of hypothalamic neurons to sense and transduce changes in leptin and insulin levels is compromised. The effects of both…”
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Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATPchannel activation by Mirshamsi, Shirin, Laidlaw, Hilary A, Ning, Ke, Anderson, Erin, Burgess, Laura A, Gray, Alexander, Sutherland, Calum, Ashford, Michael LJ

“…Abstract Background Leptin and insulin are long-term regulators of body weight. They act in hypothalamic centres to modulate the function of specific neuronal…”
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The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1 by Kinsella, Jackie M, Laidlaw, Hilary A, Tang, Teresa, Harvey, Jenni, Sutherland, Calum, Ashford, Michael L J

“…3-guanidinopropionic acid derivatives reduce body weight in obese, diabetic mice. We have assessed whether one of these analogues, the aminoguanidine…”
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Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and K sub(ATP )channel activation by Mirshamsi, Shirin, Laidlaw, Hilary A, Ning, Ke, Anderson, Erin, Burgess, Laura A, Gray, Alexander, Sutherland, Calum, Ashford, Michael LJ

“…Background: Leptin and insulin are long-term regulators of body weight. They act in hypothalamic centres to modulate the function of specific neuronal…”
Get full text