Search Results - "Ashford, Fiona"

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics by Ast, Julia, Arvaniti, Anastasia, Fine, Nicholas H. F., Nasteska, Daniela, Ashford, Fiona B., Stamataki, Zania, Koszegi, Zsombor, Bacon, Andrea, Jones, Ben J., Lucey, Maria A., Sasaki, Shugo, Brierley, Daniel I., Hastoy, Benoit, Tomas, Alejandra, D’Agostino, Giuseppe, Reimann, Frank, Lynn, Francis C., Reissaus, Christopher A., Linnemann, Amelia K., D’Este, Elisa, Calebiro, Davide, Trapp, Stefan, Johnsson, Kai, Podewin, Tom, Broichhagen, Johannes, Hodson, David J.

“…The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in metabolism. Presently, its visualization is limited to…”
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Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance by Meakin, Paul J., Chowdhry, Sudhir, Sharma, Ritu S., Ashford, Fiona B., Walsh, Shaun V., McCrimmon, Rory J., Dinkova-Kostova, Albena T., Dillon, John F., Hayes, John D., Ashford, Michael L. J.

“…Mice lacking the transcription factor NF-E2 p45-related factor 2 (Nrf2) develop more severe nonalcoholic steatohepatitis (NASH), with cirrhosis, than wild-type…”
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Validation testing to determine the sensitivity of lateral flow testing for asymptomatic SARS-CoV-2 detection in low prevalence settings: Testing frequency and public health messaging is key by Ferguson, Jack, Dunn, Steven, Best, Angus, Mirza, Jeremy, Percival, Benita, Mayhew, Megan, Megram, Oliver, Ashford, Fiona, White, Thomas, Moles-Garcia, Emma, Crawford, Liam, Plant, Tim, Bosworth, Andrew, Kidd, Michael, Richter, Alex, Deeks, Jonathan, McNally, Alan

“…Lateral flow devices (LFDs) are quickly being implemented for use in large-scale population surveillance programs for SARS-CoV-2 infection in the United…”
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Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6 by Howie, Jacqueline, Tulloch, Lindsay B., Brown, Elaine, Reilly, Louise, Ashford, Fiona B., Kennedy, Jennifer, Wypijewski, Krzysztof J., Aughton, Karen L., Mak, Jason K.C., Shattock, Michael J., Fraser, Niall J., Fuller, William

“…Phospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity. Here, we show…”
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Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells by Xu, Weiwei, Qadir, M.M. Fahd, Nasteska, Daniela, Mota de Sa, Paula, Gorvin, Caroline M., Blandino-Rosano, Manuel, Evans, Charles R., Ho, Thuong, Potapenko, Evgeniy, Veluthakal, Rajakrishnan, Ashford, Fiona B., Bitsi, Stavroula, Fan, Jia, Bhondeley, Manika, Song, Kejing, Sure, Venkata N., Sakamuri, Siva S.V.P., Schiffer, Lina, Beatty, Wandy, Wyatt, Rachael, Frigo, Daniel E., Liu, Xiaowen, Katakam, Prasad V., Arlt, Wiebke, Buck, Jochen, Levin, Lonny R., Hu, Tony, Kolls, Jay, Burant, Charles F., Tomas, Alejandra, Merrins, Matthew J., Thurmond, Debbie C., Bernal-Mizrachi, Ernesto, Hodson, David J., Mauvais-Jarvis, Franck

“…Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia…”
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Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion by Viloria, Katrina, Nasteska, Daniela, Briant, Linford J.B., Heising, Silke, Larner, Dean P., Fine, Nicholas H.F., Ashford, Fiona B., da Silva Xavier, Gabriela, Ramos, Maria Jiménez, Hasib, Annie, Cuozzo, Federica, Manning Fox, Jocelyn E., MacDonald, Patrick E., Akerman, Ildem, Lavery, Gareth G., Flaxman, Christine, Morgan, Noel G., Richardson, Sarah J., Hewison, Martin, Hodson, David J.

“…Vitamin-D-binding protein (DBP) or group-specific component of serum (GC-globulin) carries vitamin D metabolites from the circulation to target tissues. DBP is…”
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Author Correction: PDX1LOW MAFALOW β-cells contribute to islet function and insulin release by Nasteska, Daniela, Fine, Nicholas H. F., Ashford, Fiona B., Cuozzo, Federica, Viloria, Katrina, Smith, Gabrielle, Dahir, Aisha, Dawson, Peter W. J., Lai, Yu-Chiang, Bastidas-Ponce, Aimée, Bakhti, Mostafa, Rutter, Guy A., Fiancette, Remi, Nano, Rita, Piemonti, Lorenzo, Lickert, Heiko, Zhou, Qiao, Akerman, Ildem, Hodson, David J.

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PDX1LOW MAFALOW β-cells contribute to islet function and insulin release by Nasteska, Daniela, Fine, Nicholas H. F., Ashford, Fiona B., Cuozzo, Federica, Viloria, Katrina, Smith, Gabrielle, Dahir, Aisha, Dawson, Peter W. J., Lai, Yu-Chiang, Bastidas-Ponce, Aimée, Bakhti, Mostafa, Rutter, Guy A., Fiancette, Remi, Nano, Rita, Piemonti, Lorenzo, Lickert, Heiko, Zhou, Qiao, Akerman, Ildem, Hodson, David J.

“…Transcriptionally mature and immature β-cells co-exist within the adult islet. How such diversity contributes to insulin release remains poorly understood…”
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Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics by Ast, Julia, Arvaniti, Anastasia, Fine, Nicholas H. F., Nasteska, Daniela, Ashford, Fiona B., Stamataki, Zania, Koszegi, Zsombor, Bacon, Andrea, Jones, Ben J., Lucey, Maria A., Sasaki, Shugo, Brierley, Daniel I., Hastoy, Benoit, Tomas, Alejandra, D’Agostino, Giuseppe, Reimann, Frank, Lynn, Francis C., Reissaus, Christopher A., Linnemann, Amelia K., D’Este, Elisa, Calebiro, Davide, Trapp, Stefan, Johnsson, Kai, Podewin, Tom, Broichhagen, Johannes, Hodson, David J.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Increased Seroprevalence and Improved Antibody Responses Following Third Primary SARS-CoV-2 Immunisation: An Update From the COV-AD Study by Shields, Adrian M, Faustini, Sian E, Hill, Harriet J, Al-Taei, Saly, Tanner, Chloe, Ashford, Fiona, Workman, Sarita, Moreira, Fernando, Verma, Nisha, Wagg, Hollie, Heritage, Gail, Campton, Naomi, Stamataki, Zania, Drayson, Mark T, Klenerman, Paul, Thaventhiran, James E D, Elkhalifa, Shuayb, Goddard, Sarah, Johnston, Sarah, Huissoon, Aarnoud, Bethune, Claire, Elcombe, Suzanne, Lowe, David M, Patel, Smita Y, Savic, Sinisa, Richter, Alex G, Burns, Siobhan O

“…Patients with primary and secondary antibody deficiency are vulnerable to COVID-19 and demonstrate diminished responses following two-dose SARS-CoV-2 vaccine…”
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Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist by Pickford, Phil, Lucey, Maria, Rujan, Roxana-Maria, McGlone, Emma Rose, Bitsi, Stavroula, Ashford, Fiona B., Corrêa, Ivan R., Hodson, David J., Tomas, Alejandra, Deganutti, Giuseppe, Reynolds, Christopher A., Owen, Bryn M., Tan, Tricia M., Minnion, James, Jones, Ben, Bloom, Stephen R.

“…Glucagon-like peptide-1 and glucagon receptor (GLP-1R/GCGR) co-agonism can maximise weight loss and improve glycaemic control in type 2 diabetes and obesity…”
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COVID-19 vaccines are effective at preventing symptomatic and severe infection among healthcare workers: A clinical review by Galgut, Oliver, Ashford, Fiona, Deeks, Alexandra, Ghataure, Andeep, Islam, Mimia, Sambhi, Tanvir, Ker, Yiu Wayn, Duncan, Christopher J.A., de Silva, Thushan I., Hopkins, Susan, Hall, Victoria, Klenerman, Paul, Dunachie, Susanna, Richter, Alex

“…Health care workers (HCWs) have been at increased risk of infection during the SARS-CoV-2 pandemic and as essential workers have been prioritised for…”
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Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression by Watterson, Kenneth R., Bestow, Dawn, Gallagher, Jennifer, Hamilton, D. Lee, Ashford, Fiona B., Meakin, Paul J., Ashford, Michael L.J.

“…Activation of mammalian target of rapamycin 1 (mTORC1) by nutrients, insulin and leptin leads to appetite suppression (anorexia). Contrastingly, increased…”
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S-Variant SARS-CoV-2 Lineage B1.1.7 Is Associated With Significantly Higher Viral Load in Samples Tested by TaqPath Polymerase Chain Reaction by Kidd, Michael, Richter, Alex, Best, Angus, Cumley, Nicola, Mirza, Jeremy, Percival, Benita, Mayhew, Megan, Megram, Oliver, Ashford, Fiona, White, Thomas, Moles-Garcia, Emma, Crawford, Liam, Bosworth, Andrew, Atabani, Sowsan F, Plant, Tim, McNally, Alan

“…Abstract A SARS-CoV-2 variant B1.1.7 containing mutation Δ69/70 has spread rapidly in the United Kingdom and shows an identifiable profile in ThermoFisher…”
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Cysteine post‐translational modifications regulate protein interactions of caveolin‐3 by Ashford, Fiona, Kuo, Chien‐Wen, Dunning, Emma, Brown, Elaine, Calagan, Sarah, Jayasinghe, Izzy, Henderson, Colin, Fuller, William, Wypijewski, Krzysztof

“…Caveolae are small flask‐shaped invaginations of the surface membrane which are proposed to recruit and co‐localize signaling molecules. The distinctive…”
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Molecular Mechanism of Androgen Receptor Stimulation of Insulin Secretion in Male ß Cells by XU, WEIWEI, ASHFORD, FIONA B., HODSON, DAVID, MAUVAIS-JARVIS, FRANCK

“…Androgen deprivation therapy increases the risk of type 2 diabetes mellitus (T2DM) in men. We previously showed that male pancreatic β-cell specific androgen…”
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SARS-CoV-2 Vaccine Responses in Individuals with Antibody Deficiency: Findings from the COV-AD Study by Shields, Adrian M., Faustini, Sian E., Hill, Harriet J., Al-Taei, Saly, Tanner, Chloe, Ashford, Fiona, Workman, Sarita, Moreira, Fernando, Verma, Nisha, Wagg, Hollie, Heritage, Gail, Campton, Naomi, Stamataki, Zania, Klenerman, Paul, Thaventhiran, James E. D., Goddard, Sarah, Johnston, Sarah, Huissoon, Aarnoud, Bethune, Claire, Elcombe, Suzanne, Lowe, David M., Patel, Smita Y., Savic, Sinisa, Burns, Siobhan O., Richter, Alex G.

“…Background Vaccination prevents severe morbidity and mortality from COVID-19 in the general population. The immunogenicity and efficacy of SARS-CoV-2 vaccines…”
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The Impact of Pausing Bruton Tyrosine Kinase Inhibitor Therapy and Responsiveness of Vaccination in Blood Cancer Patients: Primary Outcome Result for the Randomised Improve Trial by Patten, Piers, Cook, Jonathan, Peckham, Nicholas, Moss, Paul, Phillips, Neil, Abhishek, Abhishek, Roberts, Thomas, Talbot, Georgina, Barber, Vicki, Francis, Anne, Ashford, Fiona, Duley, Lelia, Hoogeboom, Robbert, Willett, Brian, Parry-Jones, Nilima, Eyre, Toby A., Wandroo, Farooq Ahmad, Hutchinson, Claire, Murray, Duncan James, Vandici, Gratian, Martinez-Calle, Nicolas, Jenkins, Stephen, Parry, Helen M

“…Background: Patients with CLL have profound immunosuppression, higher mortality rates from COVID-19 infection and poorer responses to vaccination. Patients…”
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S-variant SARS-CoV-2 lineage B1.1.7 is associated with significantly higher viral loads in samples tested by ThermoFisher TaqPath RT-qPCR by Kidd, Michael, Richter, Alex, Best, Angus, Cumley, Nicola, Mirza, Jeremy, Percival, Benita, Mayhew, Megan, Megram, Oliver, Ashford, Fiona, White, Thomas, Moles-Garcia, Emma, Crawford, Liam, Bosworth, Andrew, Atabani, Sowsan F, Plant, Tim, McNally, Alan

“…A SARS-CoV-2 variant B1.1.7 containing a mutation Δ69/70 has spread rapidly in the UK and shows an identifiable profile in ThermoFisher TaqPath RTqPCR (S-gene…”
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SARS-CoV-2 Testing in the Community: Testing Positive Samples with the TaqMan SARS-CoV-2 Mutation Panel To Find Variants in Real Time by Ashford, Fiona, Best, Angus, Dunn, Steven J, Ahmed, Zahra, Siddiqui, Henna, Melville, Jordan, Wilkinson, Samuel, Mirza, Jeremy, Cumley, Nicola, Stockton, Joanne, Ferguson, Jack, Wheatley, Lucy, Ratcliffe, Elizabeth, Casey, Anna, Plant, Tim, Quick, Joshua, Richter, Alex, Loman, Nicholas, McNally, Alan

“…Genome sequencing is a powerful tool for identifying SARS-CoV-2 variant lineages; however, there can be limitations due to sequence dropout when used to…”
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