Search Results - "Ashery, U"

Opposing actions of environmental enrichment and Alzheimer’s disease on the expression of hippocampal microRNAs in mouse models by Barak, B, Shvarts-Serebro, I, Modai, S, Gilam, A, Okun, E, Michaelson, D M, Mattson, M P, Shomron, N, Ashery, U

“…Alzheimer’s disease (AD) is the most common form of dementia in the elderly. Although there are no drugs that modify the disease process, exposure to an…”
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Targeting damages in the brain: exosomes derived from MSC present migration and homing abilities to different neurodegenerative and neuropsychiatric locations by Offen, D, Perets, N, Betzer, O, Popovtzer, R, Shapira, R, Ashery, U

“…Background & AimOne of the greatest challenges in both neurology and psychiatry is targeted drug delivery. Most of the molecules do not cross the blood-brain…”
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Munc18-1 phosphorylation by protein kinase C potentiates vesicle pool replenishment in bovine chromaffin cells by Nili, U., de Wit, H., Gulyas-Kovacs, A., Toonen, R.F., Sørensen, J.B., Verhage, M., Ashery, U.

“…Activation of protein kinase C (PKC) after robust stimulation is necessary for vesicle pool replenishment in secretory cells. Here we studied the contribution…”
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DOC2B Acts as a Calcium Switch and Enhances Vesicle Fusion by Friedrich, Reut, Groffen, Alexander J, Connell, Emma, van Weering, Jan R. T, Gutman, Orit, Henis, Yoav I, Davletov, Bazbek, Ashery, Uri

“…Calcium-dependent exocytosis is regulated by a vast number of proteins. DOC2B is a synaptic protein that translocates to the plasma membrane (PM) after small…”
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Rasosomes originate from the Golgi to dispense Ras signals by Grunwald, A, Gottfried, I, Cox, A D, Haklai, R, Kloog, Y, Ashery, U

“…Ras proteins undergo an incompletely understood trafficking process in the cell. Rasosomes are protein nanoparticles of 80–100 nm diameter that carry lipidated…”
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Use of Aplysia neurons for the study of cellular alterations and the resealing of transected axons in vitro by Spira, M.E., Dormann, A., Ashery, U., Gabso, M., Gitler, D., Benbassat, D., Oren, R., Ziv, N.E.

“…The present report describes the experimental advantages offered by the combined use of Aplysia neurons and contemporary techniques to analyze the cellular…”
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Friends and foes in synaptic transmission: the role of tomosyn in vesicle priming by Ashery, Uri, Bielopolski, Noa, Barak, Boaz, Yizhar, Ofer

“…Priming is the process by which vesicles become available for fusion at nerve terminals and is modulated by numerous proteins and second messengers. One of the…”
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Clathrin-mediated endocytosis cooperates with bulk endocytosis to generate vesicles by Arpino, Gianvito, Somasundaram, Agila, Shin, Wonchul, Ge, Lihao, Villareal, Seth, Chan, Chung Yu, Ashery, Uri, Shupliakov, Oleg, Taraska, Justin W., Wu, Ling-Gang

“…Clathrin-mediated endocytosis, the most prominent endocytic mode, is thought to be generated primarily from relatively flat patches of the plasma membrane. By…”
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Functional Interaction of the Active Zone Proteins Munc13-1 and RIM1 in Synaptic Vesicle Priming by Betz, Andrea, Thakur, Pratima, Junge, Harald J., Ashery, Uri, Rhee, Jeong-Seop, Scheuss, Volker, Rosenmund, Christian, Rettig, Jens, Brose, Nils

“…Synaptic neurotransmitter release is restricted to active zones, where the processes of synaptic vesicle tethering, priming to fusion competence, and Ca…”
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No more brain tangles with ΔNp73 by Mattson, Mark P., Ashery, Uri

“…In Alzheimer’s disease (AD), neurons suffer dysfunction and death associated with aberrant tau phosphorylation and subsequent neurofibrillary tangles. A new…”
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DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties by Groffen, Alexander J.A, Friedrich, Reut, Brian, Elisabeth C, Ashery, Uri, Verhage, Matthijs

“…Elevation of the intracellular calcium concentration ([Ca²⁺]i) to levels below 1 µm alters synaptic transmission and induces short-term plasticity. To identify…”
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Munc13-1 Is a Presynaptic Phorbol Ester Receptor that Enhances Neurotransmitter Release by Betz, Andrea, Ashery, Uri, Rickmann, Michael, Augustin, Iris, Neher, Erwin, Südhof, Thomas C, Rettig, Jens, Brose, Nils

“…Munc13-1, a mammalian homolog of C. elegans unc-13p, is thought to be involved in the regulation of synaptic transmission. We now demonstrate that Munc13-1 is…”
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Ras and its signals diffuse through the cell on randomly moving nanoparticles by ROTBLAT, Barak, YIZHAR, Ofer, HAKLAI, Roni, ASHERY, Uri, KLOOG, Yoel

“…Spatiotemporal modulation of Ras signaling from different intracellular compartments requires mechanisms allowing Ras and its signals to navigate across cells…”
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Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex by Sheng, Zu-Hang, Chheda, Milan G, Ashery, Uri, Thakur, Pratima, Rettig, Jens

“…cAMP-dependent protein kinase A (PKA) can modulate synaptic transmission by acting directly on unknown targets in the neurotransmitter secretory machinery…”
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Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells by Ashery, Uri, Varoqueaux, Frederique, Voets, Thomas, Betz, Andrea, Thakur, Pratima, Koch, Henriette, Neher, Erwin, Brose, Nils, Rettig, Jens

“…In chromaffin cells the number of large dense‐core vesicles (LDCVs) which can be released by brief, intense stimuli represents only a small fraction of the…”
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Tomosyn Inhibits Priming of Large Dense-Core Vesicles in a Calcium-Dependent Manner by Yizhar, Ofer, Matti, Ulf, Melamed, Rely, Hagalili, Yamit, Bruns, Dieter, Rettig, Jens, Ashery, Uri, Neher, Erwin

“…Neurotransmitter release is a multistep process that is coordinated by a large number of synaptic proteins and depends on proper protein-protein interactions…”
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The SNARE Protein SNAP-25 is Linked to Fast Calcium Triggering of Exocytosis by Sørensen, Jakob B., Matti, Ulf, Wei, Shun-Hui, Nehring, Ralf B., Voets, Thomas, Ashery, Uri, Binz, Thomas, Neher, Erwin, Rettig, Jens

“…Synchronous neurotransmission depends on the tight coupling between Ca2+influx and fusion of neurotransmitter-filled vesicles with the plasma membrane. The…”
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A New Platform to Study the Molecular Mechanisms of Exocytosis by Mezer, Aviv, Nachliel, Esther, Gutman, Menachem, Ashery, Uri

“…The exocytotic process in neurons and neuroendocrine cells consists of a sequence of reactions between well defined proteins. In the present study, we have…”
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An efficient method for infection of adrenal chromaffin cells using the Semliki Forest virus gene expression system by Ashery, U, Betz, A, Xu, T, Brose, N, Rettig, J

“…We have expanded the use of the Semliki Forest virus (SFV) by infecting chromaffin cells with synaptic proteins at high efficiency. Using the SFV gene…”
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Early requirement for α-SNAP and NSF in the secretory cascade in chromaffin cells by Xu, Tao, Ashery, Uri, Burgoyne, Robert D., Neher, Erwin

“…NSF and α‐SNAP have been shown to be required for SNARE complex disassembly and exocytosis. However, the exact requirement for NSF and α‐SNAP in vesicular…”
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