Search Results - "Asher, Constance"

Speciation of Ferriprotoporphyrin IX in Aqueous and Mixed Aqueous Solution Is Controlled by Solvent Identity, pH, and Salt Concentration by Asher, Constance, de Villiers, Katherine A., Egan, Timothy J.

“…The speciation of ferriprotoporphyrin IX (Fe(III)PPIX) in aqueous and mixed aqueous−organic solvents has been investigated by UV−vis, 1H NMR, magnetic, and…”
Get full text

In vitro biotransformation, in vivo efficacy and pharmacokinetics of antimalarial chalcones by Gutteridge, Clare E, Thota, Darshan S, Curtis, Sean M, Kozar, Michael P, Li, Qigui, Xie, Lisa, Zhang, Jing, Melendez, Victor, Asher, Constance O, Luong, Thulan T, Gerena, Lucia, Nichols, Daniel A, Montip, Gettayacamin

“…4'-n-Butoxy-2,4-dimethoxy-chalcone (MBC) has been described as protecting mice from an otherwise lethal infection with Plasmodium yoelii when dosed orally at…”
Get more information

In vitro and in vivo efficacy and in vitro metabolism of 1-phenyl-3-aryl-2-propen-1-ones against Plasmodium falciparum by Gutteridge, Clare E., Nichols, Daniel A., Curtis, Sean M., Thota, Darshan S., Vo, Joseph V., Gerena, Lucia, Montip, Gettayacamin, Asher, Constance O., Diaz, Damaris S., DiTusa, Charles A., Smith, Kirsten S., Bhattacharjee, Apurba K.

“…Nine in vitro submicromolar inhibitors of Plasmodium falciparum were identified, including compound 22. They were inactive when administered orally to…”
Get full text

Cynomolgus Monkey as a Surrogate for Human Aldehyde Oxidase Metabolism of the EGFR Inhibitor BIBX1382 by Hutzler, J. Matthew, Cerny, Matthew A., Yang, Young-Sun, Asher, Constance, Wong, Diane, Frederick, Kosea, Gilpin, Kyle

Get full text

Role of Specific Cytochrome P450 Isoforms in the Conversion of Phenoxypropoxybiguanide Analogs in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines by DIAZ, Damaris S, KOZAR, Michael. P, SMITH, Kirsten S, ASHER, Constance O, SOUSA, Jason C, SCHIEHSER, Guy A, JACOBUS, David. P, MILHOUS, Wilbur. K, SKILLMAN, Donald. R, SHEARER, Todd. W

“…Phenoxypropoxybiguanides, such as PS-15, are antimalarial prodrugs analogous to the relationship of proguanil and its active metabolite cycloguanil. Unlike…”
Get full text

The role of in vitro ADME assays in antimalarial drug discovery and development by Shearer, Todd W, Smith, Kirsten S, Diaz, Damaris, Asher, Constance, Ramirez, Julio

“…The high level of attrition of drugs in clinical development has led pharmaceutical companies to increase the efficiency of their lead identification and…”
Get more information

Cynomolgus monkey as a surrogate for human aldehyde oxidase metabolism of the EGFR inhibitor BIBX1382 by Hutzler, J Matthew, Cerny, Matthew A, Yang, Young-Sun, Asher, Constance, Wong, Diane, Frederick, Kosea, Gilpin, Kyle

“…BIBX1382 was an epidermal growth factor receptor inhibitor under clinical investigation for treatment of cancer. This candidate possessed an attractive…”
Get full text