Search Results - "Ashe, Karen M."

Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease by Marshall, John, Ashe, Karen M, Bangari, Dinesh, McEachern, KerryAnne, Chuang, Wei-Lien, Pacheco, Joshua, Copeland, Diane P, Desnick, Robert J, Shayman, James A, Scheule, Ronald K, Cheng, Seng H

“…Fabry disease is an X-linked glycosphingolipid storage disorder caused by a deficiency in the activity of the lysosomal hydrolase α-galactosidase A (α-gal)…”
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Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease by Ashe, Karen M, Bangari, Dinesh, Li, Lingyun, Cabrera-Salazar, Mario A, Bercury, Scott D, Nietupski, Jennifer B, Cooper, Christopher G F, Aerts, Johannes M F G, Lee, Edward R, Copeland, Diane P, Cheng, Seng H, Scheule, Ronald K, Marshall, John

“…The neuropathic glycosphingolipidoses are a subgroup of lysosomal storage disorders for which there are no effective therapies. A potential approach is…”
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Iminosugar-based inhibitors of glucosylceramide synthase prolong survival but paradoxically increase brain glucosylceramide levels in Niemann–Pick C mice by Nietupski, Jennifer B., Pacheco, Joshua J., Chuang, Wei-Lien, Maratea, Kimberly, Li, Lingyun, Foley, Joseph, Ashe, Karen M., Cooper, Christopher G.F., Aerts, Johannes M.F.G., Copeland, Diane P., Scheule, Ronald K., Cheng, Seng H., Marshall, John

“…Niemann Pick type C (NPC) disease is a progressive neurodegenerative disease caused by mutations in NPC1 or NPC2, the gene products of which are involved in…”
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Food Insecurity and Obesity: Exploring the Role of Social Support by Ashe, Karen M, Lapane, Kate L

“…Women are disproportionately affected by both obesity and food insecurity. Food insecurity occurs when there is limited ability to acquire adequate foods. It…”
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Efficacy of Enzyme and Substrate Reduction Therapy with a Novel Antagonist of Glucosylceramide Synthase for Fabry Disease by Ashe, Karen M, Budman, Eva, Bangari, Dinesh S, Siegel, Craig S, Nietupski, Jennifer B, Wang, Bing, Desnick, Robert J, Scheule, Ronald K, Leonard, John P, Cheng, Seng H, Marshall, John

“…Fabry disease, an X-linked glycosphingolipid storage disorder, is caused by the deficient activity of α-galactosidase A (α-Gal A). This results in the…”
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Exposure to Weight Management Counseling Among Students at 8 U.S. Medical Schools by Ashe, Karen M., Geller, Alan C., Pendharkar, Jyothi A., Pbert, Lori, Crawford, Sybil, Clark, Melissa A., Frisard, Christine F., Eno, Cassie A., Faro, Jamie, Ockene, Judith K.

“…Clinical guidelines support physician intervention consistent with the Ask, Advise, Assess, Assist, Arrange framework for adults who have obesity. However,…”
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α-Galactosidase A knockout mice: progressive organ pathology resembles the type 2 later-onset phenotype of Fabry disease by Bangari, Dinesh S, Ashe, Karen M, Desnick, Robert J, Maloney, Colleen, Lydon, John, Piepenhagen, Peter, Budman, Eva, Leonard, John P, Cheng, Seng H, Marshall, John, Thurberg, Beth L

“…Fabry disease is an X-linked lysosomal storage disease caused by deficient activity of α-galactosidase A and the resultant systemic accumulation of…”
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Students’ Report of Preceptor Weight Management Counseling at Eight U.S. Medical Schools by Geller, Alan C., Ockene, Judith K., Kulkarni, Mukti, Churchill, Linda C., Frisard, Christine F., Okuliar, Catherine A., Ashe, Karen M., Crawford, Sybil L., Shaw, M. Ann, White, Katherine M., Pbert, Lori A.

“…Primary care providers, using brief counseling, can help patients increase motivation to initiate or maintain weight loss, improve diet, and increase physical…”
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Systemic Administration of AAV8-α-galactosidase A Induces Humoral Tolerance in Nonhuman Primates Despite Low Hepatic Expression by Nietupski, Jennifer B, Hurlbut, Gregory D, Ziegler, Robin J, Chu, Qiuming, Hodges, Bradley L, Ashe, Karen M, Bree, Mark, Cheng, Seng H, Gregory, Richard J, Marshall, John, Scheule, Ronald K

“…In mice, liver-restricted expression of lysosomal enzymes from adeno-associated viral serotype 8 (AAV8) vectors results in reduced antibodies to the expressed…”
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Merits of Combination Cortical, Subcortical, and Cerebellar Injections for the Treatment of Niemann-Pick Disease Type A by Bu, Jie, Ashe, Karen M, Bringas, John, Marshall, John, Dodge, James C, Cabrera-Salazar, Mario A, Forsayeth, John, Schuchman, Edward H, Bankiewicz, Krystof S, Cheng, Seng H, Shihabuddin, Lamya S., Passini, Marco A

“…Niemann-Pick disease Type A (NPA) is a neuronopathic lysosomal storage disease (LSD) caused by the loss of acid sphingomyelinase (ASM). The goals of the…”
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Design and rationale of the medical students learning weight management counseling skills (MSWeight) group randomized controlled trial by Ockene, Judith K., Ashe, Karen M., Hayes, Rashelle B., Churchill, Linda C., Crawford, Sybil L., Geller, Alan C., Jolicoeur, Denise, Olendzki, Barbara C., Basco, Maria Theresa, Pendharkar, Jyothi A., Ferguson, Kristi J., Guck, Thomas P., Margo, Katherine L., Okuliar, Catherine A., Shaw, Monica A., Soleymani, Taraneh, Stadler, Diane D., Warrier, Sarita S., Pbert, Lori

“…Physicians have an important role addressing the obesity epidemic. Lack of adequate teaching to provide weight management counseling (WMC) is cited as a reason…”
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α-Galactosidase A Knockout Mice by Bangari, Dinesh S, Ashe, Karen M, Desnick, Robert J, Maloney, Colleen, Lydon, John, Piepenhagen, Peter, Budman, Eva, Leonard, John P, Cheng, Seng H, Marshall, John, Thurberg, Beth L

“…Fabry disease is an X-linked lysosomal storage disease caused by deficient activity of α-galactosidase A and the resultant systemic accumulation of…”
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Inhibition of glycogen biosynthesis via mTORC1 suppression as an adjunct therapy for Pompe disease by Ashe, Karen M., Taylor, Kristin M., Chu, Qiuming, Meyers, Elizabeth, Ellis, Allen, Jingozyan, Varvara, Klinger, Katherine, Finn, Patrick F., Cooper, Christopher G.F., Chuang, Wei-Lien, Marshall, John, McPherson, John M., Mattaliano, Robert J., Cheng, Seng H., Scheule, Ronald K., Moreland, Rodney J.

“…Pompe disease, also known as glycogen storage disease (GSD) type II, is caused by deficiency of lysosomal acid α-glucosidase (GAA). The resulting glycogen…”
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Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in mouse brain by Ashe, Karen M, Chiu, Wan-Ling, Khalifa, Ahmed M, Nicolas, Antoine N, Brown, Bonnie L, De Martino, Randall R, Alexander, Clayton P, Waggener, Christopher T, Fischer-Stenger, Krista, Stewart, Jennifer K

“…Vesicular monoamine transporter 1 (VMAT-1) mRNA and protein were examined (1) to determine whether adult mouse brain expresses full-length VMAT-1 mRNA that can…”
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217. Comparison of Hepatic Vein and Peripheral Vein Delivery of an AAV2/8 Vector Encoding Human a-Galactosidase A to Rhesus Macaques by Hodges, Bradley L., Chu, Qiuming, Nietupski, Jennifer B., Ashe, Karen M., Taylor, Kristin M., Ziegler, Robin J., Cheng, Seng H., Marshall, John, Scheule, Ronald K.

“…In murine models of lysosomal storage diseases, sustained hepatocyte-restricted expression and secretion of the therapeutic enzyme is capable of correcting the…”
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Medical Student Weight Bias: the Relationship of Attitudinal Constructs Related to Weight Management Counseling by Eno, Cassie A., Guck, Thomas P., Soleymani, Taraneh, Ashe, Karen M., Churchill, Linda C., Crawford, Sybil L., Frisard, Christine F., Hayes, Rashelle B., Martin, Leslee, Margo, Katherine L., Pbert, Lori, Pendharkar, Jyothi A., Shaw, Monica Ann, Ockene, Judith K.

“…Obesity is a prevalent disease that is often a source of stigmatization. Weight bias has been documented in healthcare settings and associated with less…”
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Merits of Combination Cortical, Subcortical, and Cerebellar Injections for the Treatment of Niemann-Pick Disease Type A by Bu, Jie, Ashe, Karen M, Bringas, John, Marshall, John, Dodge, James C, Cabrera-Salazar, Mario A, sayeth, John, Schuchman, Edward H, Bankiewicz, Krystof S, Cheng, Seng H, Shihabuddin, Lamya S, Passini, Marco A

“…Niemann-Pick disease Type A (NPA) is a neuronopathic lysosomal storage disease (LSD) caused by the loss of acid sphingomyelinase (ASM). The goals of the…”
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Systemic Administration of AAV8-[alpha]-galactosidase A Induces Humoral Tolerance in Nonhuman Primates Despite Low Hepatic Expression by Nietupski, Jennifer B, Hurlbut, Gregory D, Ziegler, Robin J, Chu, Qiuming, Hodges, Bradley L, Ashe, Karen M, Bree, Mark, Cheng, Seng H, Gregory, Richard J, Marshall, John, Scheule, Ronald K

“…In mice, liver-restricted expression of lysosomal enzymes from adeno-associated viral serotype 8 (AAV8) vectors results in reduced antibodies to the expressed…”
Get full text