Search Results - "Ashe, Hannah"

Synthetic reversed sequences reveal default genomic states by Camellato, Brendan R., Brosh, Ran, Ashe, Hannah J., Maurano, Matthew T., Boeke, Jef D.

“…Pervasive transcriptional activity is observed across diverse species. The genomes of extant organisms have undergone billions of years of evolution, making it…”
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Synthetic regulatory genomics uncovers enhancer context dependence at the Sox2 locus by Brosh, Ran, Coelho, Camila, Ribeiro-dos-Santos, André M., Ellis, Gwen, Hogan, Megan S., Ashe, Hannah J., Somogyi, Nicolette, Ordoñez, Raquel, Luther, Raven D., Huang, Emily, Boeke, Jef D., Maurano, Matthew T.

“…Sox2 expression in mouse embryonic stem cells (mESCs) depends on a distal cluster of DNase I hypersensitive sites (DHSs), but their individual contributions…”
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Genomic context sensitizes regulatory elements to genetic disruption by Ordoñez, Raquel, Zhang, Weimin, Ellis, Gwen, Zhu, Yinan, Ashe, Hannah J, Ribeiro-Dos-Santos, André M, Brosh, Ran, Huang, Emily, Hogan, Megan S, Boeke, Jef D, Maurano, Matthew T

“…Genomic context critically modulates regulatory function but is difficult to manipulate systematically. The murine insulin-like growth factor 2 (Igf2)/H19…”
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Mouse genome rewriting and tailoring of three important disease loci by Zhang, Weimin, Golynker, Ilona, Brosh, Ran, Fajardo, Alvaro, Zhu, Yinan, Wudzinska, Aleksandra M., Ordoñez, Raquel, Ribeiro-dos-Santos, André M., Carrau, Lucia, Damani-Yokota, Payal, Yeung, Stephen T., Khairallah, Camille, Vela Gartner, Antonio, Chalhoub, Noor, Huang, Emily, Ashe, Hannah J., Khanna, Kamal M., Maurano, Matthew T., Kim, Sang Yong, tenOever, Benjamin R., Boeke, Jef D.

“…Genetically engineered mouse models (GEMMs) help us to understand human pathologies and develop new therapies, yet faithfully recapitulating human diseases in…”
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A conditional counterselectable Piga knockout in mouse embryonic stem cells for advanced genome writing applications by Zhang, Weimin, Brosh, Ran, McCulloch, Laura H., Zhu, Yinan, Ashe, Hannah, Ellis, Gwen, Camellato, Brendan R., Kim, Sang Yong, Maurano, Matthew T., Boeke, Jef D.

“…Overwriting counterselectable markers is an efficient strategy for removing wild-type DNA or replacing it with payload DNA of interest. Currently, one…”
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Synthetic reversed sequences reveal default genomic states by Camellato, Brendan R, Brosh, Ran, Ashe, Hannah J, Maurano, Matthew T, Boeke, Jef D

“…Pervasive transcriptional activity is observed across diverse species. The genomes of extant organisms have undergone billions of years of evolution, making it…”
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Role of the runt‐related transcription factor (RUNX) family in prostate cancer by Ashe, Hannah, Krakowiak, Patryk, Hasterok, Sylwia, Sleppy, Rosalie, Roller, Devin G., Gioeli, Daniel

“…Prostate cancer (PCa) is a very complex disease that is a major cause of death in men worldwide. Currently, PCa dependence on the androgen receptor (AR) has…”
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On the genetic basis of tail-loss evolution in humans and apes by Xia, Bo, Zhang, Weimin, Zhao, Guisheng, Zhang, Xinru, Bai, Jiangshan, Brosh, Ran, Wudzinska, Aleksandra, Huang, Emily, Ashe, Hannah, Ellis, Gwen, Pour, Maayan, Zhao, Yu, Coelho, Camila, Zhu, Yinan, Miller, Alexander, Dasen, Jeremy S., Maurano, Matthew T., Kim, Sang Y., Boeke, Jef D., Yanai, Itai

“…The loss of the tail is among the most notable anatomical changes to have occurred along the evolutionary lineage leading to humans and to the…”
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