Search Results - "Ashcroft, Christopher P."

Second-Generation Process Research Towards Eletriptan: A Fischer Indole Approach by Ashcroft, Christopher P, Hellier, Paul, Pettman, Alan, Watkinson, Simon

“…The development of a second-generation process for the synthesis of eletriptan via a Fischer indole cyclisation is described. The finalised process offers…”
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Survey of Solvent Usage in Papers Published in Organic Process Research & Development 1997–2012 by Ashcroft, Christopher P, Dunn, Peter J, Hayler, John D, Wells, Andrew S

“…A survey of solvent usage for papers published in Organic Process Research & Development has been carried out for the years 1997–2012. Three solvent categories…”
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Cu-Catalyzed Hydroboration of Benzylidenecyclopropanes: Reaction Optimization, (Hetero)Aryl Scope, and Origins of Pathway Selectivity by Medina, Jose M, Kang, Taeho, Erbay, Tuğçe G, Shao, Huiling, Gallego, Gary M, Yang, Shouliang, Tran-Dubé, Michelle, Richardson, Paul F, Derosa, Joseph, Helsel, Ryan T, Patman, Ryan L, Wang, Fen, Ashcroft, Christopher P, Braganza, John F, McAlpine, Indrawan, Liu, Peng, Engle, Keary M

“…The copper-catalyzed hydroboration of benzylidenecyclopropanes, conveniently accessed in one step from readily available benzaldehydes, is reported. Under…”
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Asymmetric Synthesis of an MMP-3 Inhibitor Incorporating a 2-Alkyl Succinate Motif by Ashcroft, Christopher P, Challenger, Stephen, Derrick, Andrew M, Storey, Richard, Thomson, Nicholas M

“…An efficient and practical synthesis is presented of the pharmaceutically active MMP-3 inhibitor UK-370,106 (1) via an olefination/catalytic asymmetric…”
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An Efficient and Scalable Synthesis of the Endothelin Antagonists UK-350,926 and UK-349,862 Using a Dynamic Resolution Process by Ashcroft, Christopher P, Challenger, Stephen, Clifford, David, Derrick, Andrew M, Hajikarimian, Yousef, Slucock, Keith, Silk, Terry V, Thomson, Nicholas M, Williams, John R

“…The development and scale-up of a potential manufacturing route to the endothelin antagonists UK-350,926 1 and UK-349,862 2 are described. A key synthetic…”
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Early-Stage Flow Process Development of a Key Intermediate toward PF-07265807, an AXL-MER Inhibitor Oncology Candidate by Armstrong, Cameron T., Grohowalski, Katharina, Russell, Grace, Mason, Sara, Nandiwale, Kakasaheb Y., Edwards, DaQuawn, Sheeran, Jillian, Steiman, Talia J., Critcher, Douglas J., Ashcroft, Christopher P., Diaz, Angel R., Guinness, Steven M.

“…The application of continuous processing can afford certain advantages during development and scale-up, such as enhanced risk mitigation of hazardous compounds…”
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Development of a Cost-Efficient Process Toward a Key Synthetic Intermediate of the EZH2 Inhibitor PF-06821497 by Ashcroft, Christopher P., Berne, Alexander M., Blasberg, Florian, Catlin, Kelly, Collins, Michael R., Critcher, Doug J., Desrosiers, Jean-Nicolas, Goetz, Adam, Hayward, Cheryl, Jones, Ricky A., Karmilowicz, Michael J., Keene, Nandell, Martinez, Carlos A., Monfette, Sebastien, Pattavina, Sebastian David, Perfect, Hahdi H., Ragan, John A., Rauschenberger, Blake, Sach, Neal W., Scotney, Gemma, Sutton, Scott C., Talicska, Courtney, Twiddle, Steven J.R., Haitsma, Jared Van, Wisdom, Richard

“…A cost-efficient approach for the synthesis of a key intermediate of the EZH2 inhibitor PF-06821497 was identified after performing process chemistry…”
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Route Optimization of the Noncovalent Modulator of Hemoglobin PF-07059013 for Treatment of Sickle Cell Disease through a Palladium-Mediated C–O Coupling, Part II: Pilot Plant Scale Manufacture by Abercrombie, Cameron, Ashcroft, Christopher P., Badland, Matthew, Baldwin, Aaron, Baldwin, Livia T., Brisley, Sarah, Callar, Wayne, Daddario, Pedro, Hilou, Elaa, James, Chintelle, Li, Ruizhi, Liu, Yiyang, Monfette, Sebastien, Piper, Jared L., Reyes, Giselle, Risley, Hud, Salingue, Fabrice H., Saunyama, Kudzai, Vetelino, Michael G.

“…Herein, we report the optimization of the first process chemistry route for pilot-plant-scale manufacture of PF-07059013 (1), a noncovalent modulator of…”
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Route Selection and Process Development of a Multikilogram Route to the Inhaled A2a Agonist UK-432,097 by Ashcroft, Christopher P, Dessi, Yann, Entwistle, David A, Hesmondhalgh, Lynsey C, Longstaff, Adrian, Smith, Julian D

“…This article describes the selection, process development, and scale-up of a synthetic route to a complex nucleoside analogue, the A2a agonist UK-432,097 (1),…”
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Catalyst controlled regioselective Suzuki cross-coupling of 2-(4-bromophenyl)-5-chloropyrazine by Ashcroft, Christopher P., Fussell, Steven J., Wilford, Katie

“…The Suzuki cross-coupling between 2-(4-bromophenyl)-5-chloropyrazine and a range of aryl boronic acids has been investigated. The regioselectivity of the…”
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Route Selection and Process Development of a Multikilogram Route to the Inhaled A 2a Agonist UK-432,097 by Ashcroft, Christopher P., Dessi, Yann, Entwistle, David A., Hesmondhalgh, Lynsey C., Longstaff, Adrian, Smith, Julian D

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