Search Results - "Ashby, Donovan M."
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Existence of multiple transitions of the critical state due to anesthetics
Published in Nature communications (15-08-2024)“…Scale-free statistics of coordinated neuronal activity, suggesting a universal operating mechanism across spatio-temporal scales, have been proposed as a…”
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LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields
Published in Nature communications (04-01-2021)“…Hippocampal synaptic plasticity includes both long-term potentiation (LTP) and long-term depression (LTD) of synaptic strength, and has been implicated in…”
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Inhibitory medial zona incerta pathway drives exploratory behavior by inhibiting glutamatergic cuneiform neurons
Published in Nature communications (07-02-2024)“…The cuneiform nucleus (CnF) regulates locomotor activity, which is canonically viewed as being primarily involved in initiating locomotion and regulating…”
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Selective effects of acute and chronic stress on slow and alpha-theta cortical functional connectivity and reversal with subanesthetic ketamine
Published in Neuropsychopharmacology (New York, N.Y.) (01-03-2023)“…Anxious, depressive, traumatic, and other stress-related disorders are associated with large scale brain network functional connectivity changes, yet the…”
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Peripheral Nerve Ligation Elicits Widespread Alterations in Cortical Sensory Evoked and Spontaneous Activity
Published in Scientific reports (25-10-2019)“…Peripheral neuropathies result in adaptation in primary sensory and other regions of cortex, and provide a framework for understanding the localized and…”
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Disruption of Long-Term Depression Potentiates Latent Inhibition: Key Role for Central Nucleus of the Amygdala
Published in The international journal of neuropsychopharmacology (01-07-2021)“…Abstract Background Latent inhibition (LI) reflects an adaptive form of learning impaired in certain forms of mental illness. Glutamate receptor activity is…”
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Selective Effects of D- and L-Govadine in Preclinical Tests of Positive, Negative, and Cognitive Symptoms of Schizophrenia
Published in Neuropsychopharmacology (New York, N.Y.) (01-06-2014)“…There is a critical need to develop novel pharmacotherapeutics capable of addressing the positive, negative, and cognitive symptoms of schizophrenia. Building…”
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Subchronic MK-801 treatment and post-weaning social isolation in rats: Differential effects on locomotor activity and hippocampal long-term potentiation
Published in Behavioural brain research (01-09-2010)“…Subchronic NMDA receptor antagonist treatment and post-weaning social isolation are two animal models of schizophrenia symptoms. However, behavioral and…”
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Stability of avoidance behaviour following repeated intermittent treatment with clozapine, olanzapine or D,L-govadine
Published in Behavioural pharmacology (01-02-2015)“…Most antipsychotic drugs act as dopamine D2 receptor antagonists within the basal ganglia. These compounds have efficacy in the treatment of positive symptoms…”
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A preclinical assessment of d.l-govadine as a potential antipsychotic and cognitive enhancer
Published in The international journal of neuropsychopharmacology (01-11-2012)“…Tetrahydroprotoberberines (THPBs) are compounds derived from traditional Chinese medicine and increasing preclinical evidence suggests efficacy in treatment of…”
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The 43rd Annual Meeting of the Canadian College of Neuropsychopharmacology, November 4, 2021Role of histone 3.3 lysine 27 methylation in conferring enduring stress susceptibilityDecreased medial prefrontal cortex glutamate levels in perimenopausal womenNovel treatments for autism-spectrum disorder based on genomics and systems biologyDissecting the role of DCC-positive prefrontal cortex projections in susceptibility to social defeat stress in adulthoodChronic desipramine induces norepinephrine p
Published in Journal of psychiatry & neuroscience (02-06-2022)Get full text
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