Search Results - "Ashani, Y"

Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers by Ashani, Y., Gupta, R.D., Goldsmith, M., Silman, I., Sussman, J.L., Tawfik, D.S., Leader, H.

“…Fluorogenic organophosphate inhibitors of acetylcholinesterase (AChE) homologous in structure to nerve agents provide useful probes for high throughput…”
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Laboratory Setup for Long-Term Monitoring of the Volatilization of Hazardous Materials:  Preliminary Tests of O-Ethyl S-2-(N,N-Diisopropylamino)ethyl Methylphosphonothiolate on Asphalt by Waysbort, D, Manisterski, E, Leader, H, Manisterski, B, Ashani, Y

“…Contrary to commonly used pesticides, the rate of volatilization of extremely toxic chemicals such as the nerve agent O-ethyl S-2-(N,N-diisopropylamino)ethyl…”
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United in Fight against prOstate cancer registry (UFO): Treatment patterns and quality of life from a large, multi-center, longitudinal cohort study in Asia by Kanesvaran, R., Uemura, H., Ye, D., Chiong, E., Lojanapiwat, B., Pu, Y.-S., Kumar Rawal, S., Razack, A.H.A., Zeng, H., Chung, B.H., Tsai, Y.-S., Noor Ashani, M.Y., Liu, Y., Asinas-Tan, M., Liu, W., Low, G.K.M., van Kooten Losio, M.

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The impact of molecular variants, crystallization conditions and space group on the structure-based drug design field by Orly, D., Aggarwal, N., Ashani, Y., Albeck, S., Unger, T., Rogotner, S., Silman, I., Sussman, J. L.

“…Abstract only…”
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Prevention of soman-induced cognitive deficits by pretreatment with human butyrylcholinesterase in rats by Brandeis, R, Raveh, L, Grunwald, J, Cohen, E, Ashani, Y

“…This study examined the ability of pretreatment with human serum butyrylcholinesterase (HuBChE) to prevent soman-induced cognitive impairments. Behavioral…”
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Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase by Ashani, Y, Grunwald, J, Kronman, C, Velan, B, Shafferman, A

“…Huperzine A (HUP), a natural, potent, 'slow,' reversible inhibitor of antiacetylcholinesterase (AChE), has been suggested to be superior to…”
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Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates Toxicity: a Mathematically Based Toxicokinetic Model by Ashani, Yacov, Pistinner, Shlomi

“…Human butyrylcholinesterase (HuBChE) is a drug candidate for protection against organophosphates (OP) intoxication. A mathematically based model was validated…”
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Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin by Harel, M, Su, C T, Frolow, F, Ashani, Y, Silman, I, Sussman, J L

“…"Aged" organophosphoryl conjugates of serine hydrolases differ from the corresponding "non-aged" conjugates in their striking resistance to nucleophilic…”
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Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators by Ashani, Yacov, Bhattacharjee, Apurba K., Leader, Haim, Saxena, Ashima, Doctor, Bhupendra P.

“…Oxime-induced reactivation of phosphonylated cholinesterases (ChEs) produces charged phosphonyl pyridine oxime intermediates (POXs) that are most potent…”
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Direct observation and elucidation of the structures of aged and nonaged phosphorylated cholinesterases by phosphorus-31 NMR spectroscopy by Segall, Y, Waysbort, D, Barak, D, Ariel, N, Doctor, B. P, Grunwald, J, Ashani, Y

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Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy by Steinberg, N, Van der Drift, A. C. M, Grunwald, J, Segall, Y, Shirin, E, Haas, E, Ashani, Y, Silman, I

“…Homologous aged and nonaged fluorescent organophosphorus conjugates of alpha-chymotrypsin (Cht) were used in a comparative spectroscopic study of the…”
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Prospective of human butyrylcholinesterase as a detoxifying antidote and potential regulator of controlled-release drugs by Ashani, Yacov

“…Butyrylcholinesterase from human plasma (HuBChE) is a potential drug candidate that can be employed in several therapeutic fields. This is attributed to the…”
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The Stoichiometry of Protection against Soman and VX Toxicity in Monkeys Pretreated with Human Butyrylcholinesterase by Raveh, Lily, Grauer, Ettie, Grunwald, Jacob, Cohen, E., Ashani, Yacov

“…Bioscavengers of organophophates (OP) have been examined as potential substitutes for the currently approved drug treatment against OP toxicity. The present…”
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Novel pyrene-containing organophosphates as fluorescent probes for studying aging-induced conformational changes in organophosphate-inhibited acetylcholinesterase by Amitai, G, Ashani, Y, Gafni, A, Silman, I

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Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase by Sharabi, Oz, Peleg, Yoav, Mashiach, Efrat, Vardy, Eyal, Ashani, Yacov, Silman, Israel, Sussman, Joel L., Shifman, Julia M.

“…Predicting mutations that enhance protein–protein affinity remains a challenging task, especially for high-affinity complexes. To test our capability to…”
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Tritium labeling of a powerful methylphosphonate inhibitor of cholinesterase: synthesis and biological applications by Balan, A, Barness, I, Simon, G, Levy, D, Ashani, Y

“…7-(Methylethoxy phosphinyloxy)-1-methyl-quinolinium iodide (MEPQ), a powerful anti-cholinesterase methylphosphonate ester, was labeled with tritium (9 Ci/mmol)…”
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Formation of an unstable covalent intermediate during the inhibition of electric-eel acetylcholinesterase with 1,3,2-dioxaphosphorinane 2-oxides by Ashani, Y, Leader, H

“…The kinetics of interaction of eel acetylcholinesterase (EC 3.1.1.7) with 1,3,2-dioxaphosphorinane 2-oxides were investigated. It was demonstrated that the…”
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In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide by Ashani, Y, Leader, H, Raveh, L, Bruckstein, R, Spiegelstein, M

“…Covalent molecular combinations of a cyclic phosphate (dioxaphosphorinane) and a potential leaving group, such as 3-(trimethylammonio)phenol iodide (TMPH),…”
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Laboratory setup for long-term monitoring of the volatilization of hazardous materials by Waysbort, D, Manisterski, E, Leader, H, Manisterski, B, Ashani, Y

“…Contrary to commonly used pesticides, the rate of volatilization of extremely toxic chemicals such as the nerve agent O-ethyl S-2-(N,N-diisopropylamino) ethyl…”
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Prophylaxis against Soman Inhalation Toxicity in Guinea Pigs by Pretreatment Alone with Human Serum Butyrylcholinesterase by Allon, Nahum, Raveh, Lily, Gilat, Eran, Cohen, Ephraim, Grunwald, Jacob, Ashani, Yacov

“…Human butyrylcholinesterase (HuBChE) has previously been shown to protect mice, rats, and monkeys against multiple lethal toxic doses of organophosphorus (OP)…”
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