Use of an oxygen-carrying blood substitute to improve intravascular optical coherence tomography imaging

Optical coherence tomography (OCT) is a catheter-based imaging technology with powerful resolution capable of identifying vulnerable plaques and guiding coronary intervention. However, a significant limitation of intravascular OCT imaging is its attenuation by blood. We propose that the use of an ox...

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Bibliographic Details
Published in:	Journal of Biomedical Optics Vol. 14; no. 3; pp. 034028 - 034024
Main Authors:	Hoang, Khiet C, Edris, Ahmad, Su, Jianping, Mukai, David S, Mahon, Sari, Petrov, Artiom D, Kern, Morton, Ashan, Chowdhury, Chen, Zhongping, Tromberg, Bruce J, Narula, Jagat, Brenner, Matthew
Format:	Journal Article
Language:	English
Published:	United States 2009
Subjects:	Animals Aorta Aorta, Abdominal - anatomy & histology Aorta, Abdominal - surgery Blood Blood Substitutes Fluorocarbons Flushing Image quality Imaging Injections, Intravenous intravascular imaging Male Optical Coherence Tomography Oxygen - administration & dosage Oxygen - chemistry oxygen-carrying blood substitute perfluorocarbon Rabbits Saline Sodium Chloride - chemistry Tomography, Optical Coherence - methods
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Summary:	Optical coherence tomography (OCT) is a catheter-based imaging technology with powerful resolution capable of identifying vulnerable plaques and guiding coronary intervention. However, a significant limitation of intravascular OCT imaging is its attenuation by blood. We propose that the use of an oxygen-carrying blood substitute could potentially optimize OCT image quality. Surgical isolation of the descending thoracic aorta of six rabbits is performed, followed by intravascular OCT imaging of the abdominal aorta. Perfluorodecalin (PFD) is oxygenated using a bubble-through technique with 100 oxygen. OCT imaging is performed and compared using three different flushing modalities: PFD; saline; and blood. OCT imaging of the rabbit abdominal aorta is successful in all of the subjects. In each of the six studied subjects, flushing with PFD consistently provides dramatically better imaging of the vessel wall tissue structures. OCT image quality is highly dependent on the ability of the flushing modality to remove blood from the imaging field. From this proof-of-concept study, we demonstrate that endovascular flushing with an oxygen-carrying blood substitute (PFD) is optically superior to saline flushing for intravascular imaging.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1083-3668 1560-2281
DOI:	10.1117/1.3153895