Search Results - "Ash, Peter EA"

Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS by Ash, Peter E.A., Bieniek, Kevin F., Gendron, Tania F., Caulfield, Thomas, Lin, Wen-Lang, DeJesus-Hernandez, Mariely, van Blitterswijk, Marka M., Jansen-West, Karen, Paul, Joseph W., Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard

“…Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are devastating neurodegenerative disorders with clinical, genetic, and neuropathological…”
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TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA by Saldi, Tassa K, Ash, Peter EA, Wilson, Gavin, Gonzales, Patrick, Garrido-Lecca, Alfonso, Roberts, Christine M, Dostal, Vishantie, Gendron, Tania F, Stein, Lincoln D, Blumenthal, Thomas, Petrucelli, Leonard, Link, Christopher D

“…Caenorhabditis elegans mutants deleted for TDP‐1, an ortholog of the neurodegeneration‐associated RNA‐binding protein TDP‐43, display only mild phenotypes…”
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Protein Interaction Network Biology in Neuroscience by Basu, Avik, Ash, Peter EA, Wolozin, Benjamin, Emili, Andrew

“…Mapping the intricate networks of cellular proteins in the human brain has the potential to address unsolved questions in molecular neuroscience, including the…”
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Front Cover: Protein Interaction Network Biology in Neuroscience by Basu, Avik, Ash, Peter EA, Wolozin, Benjamin, Emili, Andrew

“…DOI: 10.1002/pmic.201900311 In article number 1900311, Avik Basu et al. summarize the recent applications of functional proteomics and systems biology…”
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Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity by Vanderweyde, Tara, Apicco, Daniel J., Youmans-Kidder, Katherine, Ash, Peter E.A., Cook, Casey, Lummertz da Rocha, Edroaldo, Jansen-West, Karen, Frame, Alissa A., Citro, Allison, Leszyk, John D., Ivanov, Pavel, Abisambra, Jose F., Steffen, Martin, Li, Hu, Petrucelli, Leonard, Wolozin, Benjamin

“…Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau…”
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Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS by Gendron, Tania F., Bieniek, Kevin F., Zhang, Yong-Jie, Jansen-West, Karen, Ash, Peter E. A., Caulfield, Thomas, Daughrity, Lillian, Dunmore, Judith H., Castanedes-Casey, Monica, Chew, Jeannie, Cosio, Danielle M., van Blitterswijk, Marka, Lee, Wing C., Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard

“…Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are devastating neurodegenerative disorders with clinical, genetic, and neuropathological…”
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Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress by Zhang, Yong-Jie, Jansen-West, Karen, Xu, Ya-Fei, Gendron, Tania F., Bieniek, Kevin F., Lin, Wen-Lang, Sasaguri, Hiroki, Caulfield, Thomas, Hubbard, Jaime, Daughrity, Lillian, Chew, Jeannie, Belzil, Veronique V., Prudencio, Mercedes, Stankowski, Jeannette N., Castanedes-Casey, Monica, Whitelaw, Ena, Ash, Peter E. A., DeTure, Michael, Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard

“…The occurrence of repeat-associated non-ATG (RAN) translation, an atypical form of translation of expanded repeats that results in the synthesis of…”
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Neurotoxic effects of TDP-43 overexpression in C. elegans by Ash, Peter E.A., Zhang, Yong-Jie, Roberts, Christine M., Saldi, Tassa, Hutter, Harald, Buratti, Emanuele, Petrucelli, Leonard, Link, Christopher D.

“…RNA-binding protein TDP-43 has been associated with multiple neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar…”
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A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins by Ruan, Qiu T, Yazdani, Neema, Blum, Benjamin C, Beierle, Jacob A, Lin, Weiwei, Coelho, Michal A, Fultz, Elissa K, Healy, Aidan F, Shahin, John R, Kandola, Amarpreet K, Luttik, Kimberly P, Zheng, Karen, Smith, Nathaniel J, Cheung, Justin, Mortazavi, Farzad, Apicco, Daniel J, Ragu Varman, Durairaj, Ramamoorthy, Sammanda, Ash, Peter E A, Rosene, Douglas L, Emili, Andrew, Wolozin, Benjamin, Szumlinski, Karen K, Bryant, Camron D

“…Individual variation in the addiction liability of amphetamines has a heritable genetic component. We previously identified (heterogeneous nuclear…”
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TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans by Vaccaro, Alexandra, Tauffenberger, Arnaud, Ash, Peter E A, Carlomagno, Yari, Petrucelli, Leonard, Parker, J Alex

“…TDP-43 is a multifunctional nucleic acid binding protein linked to several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS) and…”
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TDP ‐1, the C aenorhabditis elegans ortholog of TDP ‐43, limits the accumulation of double‐stranded RNA by Saldi, Tassa K, Ash, Peter EA, Wilson, Gavin, Gonzales, Patrick, Garrido‐Lecca, Alfonso, Roberts, Christine M, Dostal, Vishantie, Gendron, Tania F, Stein, Lincoln D, Blumenthal, Thomas, Petrucelli, Leonard, Link, Christopher D

“…Caenorhabditis elegans mutants deleted for TDP ‐1, an ortholog of the neurodegeneration‐associated RNA ‐binding protein TDP ‐43, display only mild phenotypes…”
Get full text