Search Results - "Ash, Peter E A"

Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS by Gendron, Tania F., Bieniek, Kevin F., Zhang, Yong-Jie, Jansen-West, Karen, Ash, Peter E. A., Caulfield, Thomas, Daughrity, Lillian, Dunmore, Judith H., Castanedes-Casey, Monica, Chew, Jeannie, Cosio, Danielle M., van Blitterswijk, Marka, Lee, Wing C., Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard

“…Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are devastating neurodegenerative disorders with clinical, genetic, and neuropathological…”
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Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress by Zhang, Yong-Jie, Jansen-West, Karen, Xu, Ya-Fei, Gendron, Tania F., Bieniek, Kevin F., Lin, Wen-Lang, Sasaguri, Hiroki, Caulfield, Thomas, Hubbard, Jaime, Daughrity, Lillian, Chew, Jeannie, Belzil, Veronique V., Prudencio, Mercedes, Stankowski, Jeannette N., Castanedes-Casey, Monica, Whitelaw, Ena, Ash, Peter E. A., DeTure, Michael, Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard

“…The occurrence of repeat-associated non-ATG (RAN) translation, an atypical form of translation of expanded repeats that results in the synthesis of…”
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Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo by Apicco, Daniel J., Ash, Peter E. A., Maziuk, Brandon, LeBlang, Chelsey, Medalla, Maria, Al Abdullatif, Ali, Ferragud, Antonio, Botelho, Emily, Ballance, Heather I., Dhawan, Uma, Boudeau, Samantha, Cruz, Anna Lourdes, Kashy, Daniel, Wong, Aria, Goldberg, Lisa R., Yazdani, Neema, Zhang, Cheng, Ung, Choong Y., Tripodis, Yorghos, Kanaan, Nicholas M., Ikezu, Tsuneya, Cottone, Pietro, Leszyk, John, Li, Hu, Luebke, Jennifer, Bryant, Camron D., Wolozin, Benjamin

“…Emerging studies suggest a role for tau in regulating the biology of RNA binding proteins (RBPs). We now show that reducing the RBP T-cell intracellular…”
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TIA1 regulates the generation and response to toxic tau oligomers by Jiang, Lulu, Ash, Peter E. A., Maziuk, Brandon F., Ballance, Heather I., Boudeau, Samantha, Abdullatif, Ali Al, Orlando, Marcello, Petrucelli, Leonard, Ikezu, Tsuneya, Wolozin, Benjamin

“…RNA binding proteins (RBPs) are strongly linked to the pathophysiology of motor neuron diseases. Recent studies show that RBPs, such as TIA1, also contribute…”
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Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS by Ash, Peter E.A., Bieniek, Kevin F., Gendron, Tania F., Caulfield, Thomas, Lin, Wen-Lang, DeJesus-Hernandez, Mariely, van Blitterswijk, Marka M., Jansen-West, Karen, Paul, Joseph W., Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard

“…Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are devastating neurodegenerative disorders with clinical, genetic, and neuropathological…”
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RNA binding proteins co-localize with small tau inclusions in tauopathy by Maziuk, Brandon F, Apicco, Daniel J, Cruz, Anna Lourdes, Jiang, Lulu, Ash, Peter E A, da Rocha, Edroaldo Lummertz, Zhang, Cheng, Yu, Wai Haung, Leszyk, John, Abisambra, Jose F, Li, Hu, Wolozin, Benjamin

“…The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies,…”
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Neurotoxic effects of TDP-43 overexpression in C. elegans by Ash, Peter E.A., Zhang, Yong-Jie, Roberts, Christine M., Saldi, Tassa, Hutter, Harald, Buratti, Emanuele, Petrucelli, Leonard, Link, Christopher D.

“…RNA-binding protein TDP-43 has been associated with multiple neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar…”
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Mutations in LRRK2 potentiate age-related impairment of autophagic flux by Saha, Shamol, Ash, Peter E A, Gowda, Vivek, Liu, Liqun, Shirihai, Orian, Wolozin, Benjamin

“…Autophagy is thought to play a pivotal role in the pathophysiology of Parkinson's disease, but little is known about how genes linked to PD affect autophagy in…”
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TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans by Vaccaro, Alexandra, Tauffenberger, Arnaud, Ash, Peter E A, Carlomagno, Yari, Petrucelli, Leonard, Parker, J Alex

“…TDP-43 is a multifunctional nucleic acid binding protein linked to several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS) and…”
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Pathological stress granules in Alzheimer’s disease by Ash, Peter E.A, Vanderweyde, Tara E, Youmans, Katherine L, Apicco, Daniel J, Wolozin, Benjamin

“…Abstract A feature of neurodegenerative disease is the accumulation of insoluble protein aggregates in the brain. In some conditions, including Amyotrophic…”
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Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity by Vanderweyde, Tara, Apicco, Daniel J., Youmans-Kidder, Katherine, Ash, Peter E.A., Cook, Casey, Lummertz da Rocha, Edroaldo, Jansen-West, Karen, Frame, Alissa A., Citro, Allison, Leszyk, John D., Ivanov, Pavel, Abisambra, Jose F., Steffen, Martin, Li, Hu, Petrucelli, Leonard, Wolozin, Benjamin

“…Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau…”
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A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins by Ruan, Qiu T, Yazdani, Neema, Blum, Benjamin C, Beierle, Jacob A, Lin, Weiwei, Coelho, Michal A, Fultz, Elissa K, Healy, Aidan F, Shahin, John R, Kandola, Amarpreet K, Luttik, Kimberly P, Zheng, Karen, Smith, Nathaniel J, Cheung, Justin, Mortazavi, Farzad, Apicco, Daniel J, Ragu Varman, Durairaj, Ramamoorthy, Sammanda, Ash, Peter E A, Rosene, Douglas L, Emili, Andrew, Wolozin, Benjamin, Szumlinski, Karen K, Bryant, Camron D

“…Individual variation in the addiction liability of amphetamines has a heritable genetic component. We previously identified (heterogeneous nuclear…”
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Dioxins and related environmental contaminants increase TDP-43 levels by Ash, Peter E A, Stanford, Elizabeth A, Al Abdulatif, Ali, Ramirez-Cardenas, Alejandra, Ballance, Heather I, Boudeau, Samantha, Jeh, Amanda, Murithi, James M, Tripodis, Yorghos, Murphy, George J, Sherr, David H, Wolozin, Benjamin

“…Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative condition that is characterized by progressive loss of motor neurons and the…”
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TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA by Saldi, Tassa K, Ash, Peter EA, Wilson, Gavin, Gonzales, Patrick, Garrido-Lecca, Alfonso, Roberts, Christine M, Dostal, Vishantie, Gendron, Tania F, Stein, Lincoln D, Blumenthal, Thomas, Petrucelli, Leonard, Link, Christopher D

“…Caenorhabditis elegans mutants deleted for TDP‐1, an ortholog of the neurodegeneration‐associated RNA‐binding protein TDP‐43, display only mild phenotypes…”
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Interaction of tau with HNRNPA2B1 and N 6 -methyladenosine RNA mediates the progression of tauopathy by Jiang, Lulu, Lin, Weiwei, Zhang, Cheng, Ash, Peter E A, Verma, Mamta, Kwan, Julian, van Vliet, Emily, Yang, Zhuo, Cruz, Anna Lourdes, Boudeau, Samantha, Maziuk, Brandon F, Lei, Shuwen, Song, Jaehyup, Alvarez, Victor E, Hovde, Stacy, Abisambra, Jose F, Kuo, Min-Hao, Kanaan, Nicholas, Murray, Melissa E, Crary, John F, Zhao, Jian, Cheng, Ji-Xin, Petrucelli, Leonard, Li, Hu, Emili, Andrew, Wolozin, Benjamin

“…The microtubule-associated protein tau oligomerizes, but the actions of oligomeric tau (oTau) are unknown. We have used Cry2-based optogenetics to induce tau…”
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TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau by Ash, Peter E. A., Lei, Shuwen, Shattuck, Jenifer, Boudeau, Samantha, Carlomagno, Yari, Medalla, Maria, Mashimo, Bryce L., Socorro, Guillermo, Al-Mohanna, Louloua F. A., Jiang, Lulu, Öztürk, Muhammet M., Knobel, Mark, Ivanov, Pavel, Petrucelli, Leonard, Wegmann, Susanne, Kanaan, Nicholas M., Wolozin, Benjamin

“…Tau protein plays an important role in the biology of stress granules and in the stress response of neurons, but the nature of these biochemical interactions…”
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Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology by Ash, Peter E A, Dhawan, Uma, Boudeau, Samantha, Lei, Shuwen, Carlomagno, Yari, Knobel, Mark, Al Mohanna, Louloua F A, Boomhower, Steven R, Newland, M Christopher, Sherr, David H, Wolozin, Benjamin

“…Abstract Heavy metals, such as lead, mercury, and selenium, have been epidemiologically linked with a risk of ALS, but a molecular mechanism proving the…”
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Protein Interaction Network Biology in Neuroscience by Basu, Avik, Ash, Peter EA, Wolozin, Benjamin, Emili, Andrew

“…Mapping the intricate networks of cellular proteins in the human brain has the potential to address unsolved questions in molecular neuroscience, including the…”
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5′ UTR variants in the quantitative trait gene Hnrnph1 support reduced 5′ UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity by Ruan, Qiu T., Yazdani, Neema, Reed, Eric R., Beierle, Jacob A., Peterson, Lucy P., Luttik, Kimberly P., Szumlinski, Karen K., Johnson, William E., Ash, Peter E.A., Wolozin, Benjamin, Bryant, Camron D.

“…We previously identified a 210 kb region on chromosome 11 (50.37‐50.58 Mb, mm10) containing two protein‐coding genes (Hnrnph1, Rufy1) that was necessary for…”
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Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy by Jiang, Lulu, Lin, Weiwei, Zhang, Cheng, Ash, Peter E.A., Verma, Mamta, Kwan, Julian, van Vliet, Emily, Yang, Zhuo, Cruz, Anna Lourdes, Boudeau, Samantha, Maziuk, Brandon F., Lei, Shuwen, Song, Jaehyup, Alvarez, Victor E., Hovde, Stacy, Abisambra, Jose F., Kuo, Min-Hao, Kanaan, Nicholas, Murray, Melissa E., Crary, John F., Zhao, Jian, Cheng, Ji-Xin, Petrucelli, Leonard, Li, Hu, Emili, Andrew, Wolozin, Benjamin

“…The microtubule-associated protein tau oligomerizes, but the actions of oligomeric tau (oTau) are unknown. We have used Cry2-based optogenetics to induce tau…”
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