Search Results - "Asghar, Syed S."

Expression of terminal complement components by human keratinocytes by Timár, Krisztina K., Dallos, Attila, Kiss, Mária, Husz, Sándor, Bos, Jan D., Asghar, Syed S.

“…Human keratinocytes are important constituents of the skin immune system. They produce several cytokines, chemokines as well as some complement proteins. As…”
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Human keratinocytes produce the complement inhibitor factor I: Synthesis is regulated by interferon-γ by Timár, Krisztina K., Junnikkala, Sami, Dallos, Attila, Jarva, Hanna, Bhuiyan, Zahurul A., Meri, Seppo, Bos, Jan D., Asghar, Syed S.

“…Extrahepatic complement synthesis is believed to play an important role in host defense and inflammation at tissue and organ level. In the epidermis the most…”
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Human keratinocytes produce the complement inhibitor factor H: Synthesis is regulated by interferon-γ by Timár, Krisztina K., Pasch, Marcel C., Bosch, Norbert H.A. van den, Jarva, Hanna, Junnikkala, Sami, Meri, Seppo, Bos, Jan D., Asghar, Syed S.

“…Locally synthesized complement is believed to play an important role in host defense and inflammation at organ level. In the epidermis, keratinocytes have so…”
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Synthesis of Complement Components C3 and Factor B in Human Keratinocytes is Differentially Regulated by Cytokines by Pasch, Marcel C., van den Bosch, Norbert H.A., Bos, Jan D., Asghar, Syed S., Daha, Mohamed R.

“…The complement system plays an important part in host defense and inflammation. Locally synthesized complement may perform these functions at tissue and organ…”
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In situ demonstration of CD40- and CD154-positive cells in psoriatic lesions and keratinocyte production of chemokines by CD40 ligation in vitro by Pasch, Marcel C, Timár, Krisztina K, van Meurs, Marjan, Heydendael, Vera MR, Bos, Jan D, Laman, Jon D, Asghar, Syed S

“…In psoriatic lesions, T cells and keratinocytes are in an activated state. Ligation of CD40 expressed on activated keratinocytes with CD154 expressed on…”
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Defensins and complement systems from the perspective of skin immunity and autoimmunity by Bos, Jan D, Pasch, Marcel C, Asghar, Syed S

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Molecular Heterogeneity of the Fourth Component of Complement (C4) and its Genes in Vitiligo by Venneker, Gerard T, Westerhof, Wiete, de Vries, Ivan J, Drayer, Nick M, Wolthers, Bert G, de Waal, Leo P, Bos, Jan D, Asghar, Syed S

“…In view of evidence suggesting vitiligo is an autoimmune disease, we investigated whether vitiligo is associated with inherited deficiencies of the fourth (C4)…”
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In situ demonstration of CD40- and CDI54-positive cells in psoriatic lesions and keratinocyte production of chemokines by CD40 ligation in vitro by PASCH, Marcel C, TIMAR, Krisztina K, VAN MEURS, Marjan, HEYDENDAEL, Vera M. R, BOS, Jan D, LAMAN, Jon D, ASGHAR, Syed S

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Transforming growth factor‐β isoforms regulate the surface expression on membrane cofactor protein (CD46) and CD59 on human keratinocytes by Pasch, Marcel C., Bos, Jan D., Daha, Mohamed R., Asghar, Syed S.

“…We studied the regulation of the expression of complement regulatory proteins, membrane cofactor protein (MCP), decay accelerating factor (DAF) and CD59, on…”
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Prolonged Increase of cis-Urocanic Acid Levels in Human Skin and Urine after Single Total-body Ultraviolet Exposures by Kammeyer, Arthur, Pavel, Stanislav, Asghar, Syed S., Bos, Jan D., Teunissen, Marcel B. M.

“…Cis-urocanic acid (cis-UCA), a mediator of immunosuppression, is formed from trans-UCA upon UV-exposure of the skin. This study describes a liquid…”
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Skin reactions caused by phenylbutazone. Immunologic studies by van Joost, T, Asghar, S S, Cormane, R H

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Hereditary deficiency of C2 in association with linear scleroderma 'en coup de sabre' by Hulsmans, R F, Asghar, S S, Siddiqui, A H, Cormane, R H

“…A 32-year-old man suffering from linear frontoparietal scleroderma was found to have low (less than 10% normal) serum classical pathway activity although C1q,…”
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Effects of UVB on the Synthesis of Complement Proteins by Keratinocytes by Pasch, Marcel C., Okada, Noriko, Bos, Jan D., Asghar, Syed S.

“…UVB exposure of the skin results in increased production of several cytokines by keratinocytes and infiltration of inflammatory cells. We hypothesized that UVB…”
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Basic fibroblast growth factor promotes melanin synthesis by melanocytes by PURI, N, VAN DER WEEL, M. B, DE WIT, F. S, ASGHAR, S. S, DAS, P. K, RAMAIAH, A, WESTERHOF, W

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Glycosylphosphatidylinositol (GPI)-anchored membrane proteins are constitutively down-regulated in psoriatic skin by Venneker, G T, Das, P K, Meinardi, M M, van Marle, J, van Veen, H A, Bos, J D, Asghar, S S

“…Hyperproliferation of keratinocytes (KCs) in psoriasis has been found to be associated with excessive activation of a phospholipase C (PLC)/protein kinase C…”
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Relative Contributions of Decay Accelerating Factor (DAF), Membrane Cofactor Protein (MCP) and CD59 in the Protection of Melanocytes from Homologous Complement by Venneker, Gerhard T., Vodegel, Robert M., Okada, Norico, Westerhof, Wiete, Bos, Jan D., Asghar, Syed S.

“…Complement regulatory molecules, membrane cofactor protein (MCP), decay accelerating factor (DAF) and CD59, protect body cells from autologous complement. They…”
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HLA associations in vitiligo patients in the Dutch population by Venneker, G T, de Waal, L P, Westerhof, W, D'Amaro, J, Schreuder, G M, Asghar, S S

“…This study characterizes the HLA class I and class II antigens in a group of patients with vitiligo and a control group, both of Dutch descent. Earlier reports…”
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Hereditary deficiency of C5 in association with discoid lupus erythematosus by Asghar, S S, Venneker, G T, van Meegen, M, Meinardi, M M, Hulsmans, R F, de Waal, L P

“…A 29-year-old woman with discoid lupus erythematosus had undetectable classic pathway complement activity. Hypocomplementemia was due to selective deficiency…”
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A new method for the estimation of C3d. Affinity clearance of C-determinant-bearing C3 molecules and fragments followed by estimation of C3d by ELISA by Asghar, S S, Schraag, B, Backhaus, A H, Zorn, I, Venneker, G T, Hannema, A J

“…A method is described to quantitate human complement fragment C3d. Test samples were treated with a predetermined excess of anti-C3c-Sepharose beads in the…”
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Psoriasis specific chromosomal proteins, antibodies against them and disease activity by Cormane, R H, Asghar, S S

“…It has been demonstrated recently that the lymphoid cells of patients with psoriasis have antibodies directed against the psoriasis specific non-histone…”
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