Search Results - "Asfar, Pierre"

Dangers of hyperoxia by Singer, Mervyn, Young, Paul J, Laffey, John G, Asfar, Pierre, Taccone, Fabio Silvio, Skrifvars, Markus B, Meyhoff, Christian S, Radermacher, Peter

“…Oxygen (O ) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS). Supplemental…”
Get full text

Norepinephrine and Vasopressin in Hemorrhagic Shock: A Focus on Renal Hemodynamics by Fage, Nicolas, Asfar, Pierre, Radermacher, Peter, Demiselle, Julien

“…During hemorrhagic shock, blood loss causes a fall in blood pressure, decreases cardiac output, and, consequently, O transport. The current guidelines…”
Get full text

Vasopressin and its analogues in shock states: a review by Demiselle, Julien, Fage, Nicolas, Radermacher, Peter, Asfar, Pierre

“…Activation of arginine–vasopressin is one of the hormonal responses to face vasodilation-related hypotension. Released from the post-pituitary gland,…”
Get full text

Optimizing mean arterial pressure in septic shock: a critical reappraisal of the literature by Leone, Marc, Asfar, Pierre, Radermacher, Peter, Vincent, Jean-Louis, Martin, Claude

“…Guidelines recommend that a mean arterial pressure (MAP) value greater than 65 mm Hg should be the initial blood pressure target in septic shock, but what…”
Get full text

Recruitability and effect of PEEP in SARS-Cov-2-associated acute respiratory distress syndrome by Beloncle, François M., Pavlovsky, Bertrand, Desprez, Christophe, Fage, Nicolas, Olivier, Pierre-Yves, Asfar, Pierre, Richard, Jean-Christophe, Mercat, Alain

“…Background A large proportion of patients with a SARS-Cov-2-associated respiratory failure develop an acute respiratory distress syndrome (ARDS). It has been…”
Get full text

Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial by Asfar, Pierre, Prof, Schortgen, Frédérique, MD, Boisramé-Helms, Julie, MD, Charpentier, Julien, MD, Guérot, Emmanuel, MD, Megarbane, Bruno, Prof, Grimaldi, David, MD, Grelon, Fabien, MD, Anguel, Nadia, MD, Lasocki, Sigismond, Prof, Henry-Lagarrigue, Matthieu, MD, Gonzalez, Frédéric, MD, Legay, François, MD, Guitton, Christophe, MD, Schenck, Maleka, MD, Doise, Jean Marc, MD, Devaquet, Jérôme, MD, Van Der Linden, Thierry, Prof, Chatellier, Delphine, MD, Rigaud, Jean Philippe, MD, Dellamonica, Jean, Prof, Tamion, Fabienne, Prof, Meziani, Ferhat, Prof, Mercat, Alain, Prof, Dreyfuss, Didier, Prof, Seegers, Valérie, MD, Radermacher, Peter, Prof

“…Summary Background There is insufficient research into the use of mechanical ventilation with increased inspiratory oxygen concentration (FiO2 ) and fluid…”
Get full text

Pooled analysis of higher versus lower blood pressure targets for vasopressor therapy septic and vasodilatory shock by Lamontagne, François, Day, Andrew G., Meade, Maureen O., Cook, Deborah J., Guyatt, Gordon H., Hylands, Mathieu, Radermacher, Peter, Chrétien, Jean-Marie, Beaudoin, Nicolas, Hébert, Paul, D’Aragon, Frédérick, Meziani, Ferhat, Asfar, Pierre

“…Purpose Guidelines for shock recommend mean arterial pressure (MAP) targets for vasopressor therapy of at least 65 mmHg and, until recently, suggested that…”
Get full text

Long-term immunosuppressive treatment is not associated with worse outcome in patients hospitalized in the intensive care unit for septic shock: the PACIFIC study by Vaidie, Julien, Peju, Edwige, Jandeaux, Louise-Marie, Lesouhaitier, Mathieu, Lacherade, Jean-Claude, Guillon, Antoine, Wittebole, Xavier, Asfar, Pierre, Evrard, Bruno, Daix, Thomas, Vignon, Philippe, François, Bruno

“…Abstract Background Except in a few retrospective studies mainly including patients under chemotherapy, information regarding the impact of immunosuppressive…”
Get full text

Early steroids and ventilator-associated pneumonia in COVID-19-related ARDS by Lamouche-Wilquin, Pauline, Souchard, Jérôme, Pere, Morgane, Raymond, Matthieu, Asfar, Pierre, Darreau, Cédric, Reizine, Florian, Hourmant, Baptiste, Colin, Gwenhaël, Rieul, Guillaume, Kergoat, Pierre, Frérou, Aurélien, Lorber, Julien, Auchabie, Johann, La Combe, Béatrice, Seguin, Philippe, Egreteau, Pierre-Yves, Morin, Jean, Fedun, Yannick, Canet, Emmanuel, Lascarrou, Jean-Baptiste, Delbove, Agathe

“…Abstract Rationale Early corticosteroid treatment is used to treat COVID-19-related acute respiratory distress syndrome (ARDS). Infection is a well-documented…”
Get full text

Impact of treating iron deficiency, diagnosed according to hepcidin quantification, on outcomes after a prolonged ICU stay compared to standard care: a multicenter, randomized, single-blinded trial by Lasocki, Sigismond, Asfar, Pierre, Jaber, Samir, Ferrandiere, Martine, Kerforne, Thomas, Asehnoune, Karim, Montravers, Philippe, Seguin, Philippe, Peoc'h, Katell, Gergaud, Soizic, Nagot, Nicolas, Lefebvre, Thibaud, Lehmann, Sylvain

“…Anemia is a significant problem in patients on ICU. Its commonest cause, iron deficiency (ID), is difficult to diagnose in the context of inflammation…”
Get full text

Current use of vasopressors in septic shock by Scheeren, Thomas W. L., Bakker, Jan, De Backer, Daniel, Annane, Djillali, Asfar, Pierre, Boerma, E. Christiaan, Cecconi, Maurizio, Dubin, Arnaldo, Dünser, Martin W., Duranteau, Jacques, Gordon, Anthony C., Hamzaoui, Olfa, Hernández, Glenn, Leone, Marc, Levy, Bruno, Martin, Claude, Mebazaa, Alexandre, Monnet, Xavier, Morelli, Andrea, Payen, Didier, Pearse, Rupert, Pinsky, Michael R., Radermacher, Peter, Reuter, Daniel, Saugel, Bernd, Sakr, Yasser, Singer, Mervyn, Squara, Pierre, Vieillard-Baron, Antoine, Vignon, Philippe, Vistisen, Simon T., van der Horst, Iwan C. C., Vincent, Jean-Louis, Teboul, Jean-Louis

“…Background Vasopressors are commonly applied to restore and maintain blood pressure in patients with sepsis. We aimed to evaluate the current practice and…”
Get full text

Hemodynamic support in the early phase of septic shock: a review of challenges and unanswered questions by Lesur, Olivier, Delile, Eugénie, Asfar, Pierre, Radermacher, Peter

“…Background Improving sepsis support is one of the three pillars of a 2017 resolution according to the World Health Organization (WHO). Septic shock is indeed a…”
Get full text

Impact of daily cyclic enteral nutrition versus standard continuous enteral nutrition in critically ill patients: a study protocol for a randomised controlled trial in three intensive care units in France (DC-SCENIC) by Callahan, Jean-Christophe, Parot-Schinkel, Elsa, Asfar, Pierre, Ehrmann, Stephan, Tirot, Patrice, Guitton, Christophe

“…IntroductionCurrent guidelines on clinical nutrition of ventilated patients in the intensive care unit (ICU) recommend initiating continuous enteral nutrition…”
Get full text

Microparticles are new biomarkers of septic shock-induced disseminated intravascular coagulopathy by Delabranche, Xavier, Boisramé-Helms, Julie, Asfar, Pierre, Berger, Asaël, Mootien, Yoganaden, Lavigne, Thierry, Grunebaum, Lélia, Lanza, François, Gachet, Christian, Freyssinet, Jean-Marie, Toti, Florence, Meziani, Ferhat

“…Purpose Septic shock-induced disseminated intravascular coagulopathy (DIC) contributes to multiple organ failure. Mechanisms governing vascular responses to…”
Get full text

Prophylactic platelet transfusion response in critically ill patients: a prospective multicentre observational study by Reizine, Florian, Le Marec, Sarah, Le Meur, Anthony, Consigny, Maëlys, Berteau, Florian, Bodenes, Laetitia, Geslain, Marie, McQuilten, Zoe, Le Niger, Catherine, Huntzinger, Julien, Seguin, Philippe, Thibert, Jean-Baptiste, Simon, David, Reignier, Jean, Egreteau, Pierre-Yves, Tadié, Jean-Marc, Huet, Olivier, Asfar, Pierre, Ehrmann, Stephan, Aubron, Cécile

“…Abstract Background Response to prophylactic platelet transfusion is suspected to be inconsistent in critically ill patients questioning how to optimize…”
Get full text

The Effect of Targeted Hyperoxemia on Brain Immunohistochemistry after Long-Term, Resuscitated Porcine Acute Subdural Hematoma and Hemorrhagic Shock by Münz, Franziska, Datzmann, Thomas, Hoffmann, Andrea, Gröger, Michael, Mathieu, René, Mayer, Simon, Zink, Fabian, Gässler, Holger, Wolfschmitt, Eva-Maria, Hogg, Melanie, Calzia, Enrico, Asfar, Pierre, Radermacher, Peter, Kapapa, Thomas, Merz, Tamara

“…Epidemiological data suggest that moderate hyperoxemia may be associated with an improved outcome after traumatic brain injury. In a prospective, randomized…”
Get full text

Bench-to-bedside review: circulating microparticles--a new player in sepsis? by Meziani, Ferhat, Delabranche, Xavier, Asfar, Pierre, Toti, Florence

“…In sepsis, inflammation and thrombosis are both the cause and the result of interactions between circulating (for example, leukocytes and platelets),…”
Get full text

Target arterial PO2 according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients by Demiselle, Julien, Calzia, Enrico, Hartmann, Clair, Messerer, David Alexander Christian, Asfar, Pierre, Radermacher, Peter, Datzmann, Thomas

“…There is an ongoing discussion whether hyperoxia , i.e. ventilation with high inspiratory O 2 concentrations (F I O 2 ), and the consecutive hyperoxaemia ,…”
Get full text

Systemic microvascular shunting through hyperdynamic capillaries after acute physiological disturbances following cardiopulmonary bypass by Koning, Nick J, Simon, Lotte E, Asfar, Pierre, Baufreton, Christophe, Boer, Christa

“…Previously we showed that cardiopulmonary bypass (CPB) during cardiac surgery is associated with reduced sublingual microcirculatory perfusion and oxygenation…”
Get more information

FX06 to rescue SARS-CoV-2-induced acute respiratory distress syndrome: a randomized clinical trial by Guérin, Emmanuelle, Belin, Lisa, Franchineau, Guillaume, Le Guennec, Loïc, Hajage, David, Diallo, Mamadou Hassimiou, Frapard, Thomas, Le Fèvre, Lucie, Luyt, Charles-Edouard, Combes, Alain, Germain, Stéphane, Hayon, Jan, Asfar, Pierre, Bréchot, Nicolas

“…Abstract Background Vascular leakage is a major feature of acute respiratory distress syndrome (ARDS). We aimed to evaluate the efficacy of FX06, a drug under…”
Get full text