Search Results - "Asenjo, Ana B."

Cryo-EM unveils kinesin KIF1A’s processivity mechanism and the impact of its pathogenic variant P305L by Benoit, Matthieu P. M. H., Rao, Lu, Asenjo, Ana B., Gennerich, Arne, Sosa, Hernando

“…Mutations in the microtubule-associated motor protein KIF1A lead to severe neurological conditions known as KIF1A-associated neurological disorders (KAND)…”
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Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s by Benoit, Matthieu P.M.H., Asenjo, Ana B., Sosa, Hernando

“…Kinesin-13s constitute a distinct group within the kinesin superfamily of motor proteins that promote microtubule depolymerization and lack motile activity…”
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Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape by Hunter, Byron, Benoit, Matthieu P. M. H., Asenjo, Ana B., Doubleday, Caitlin, Trofimova, Daria, Frazer, Corey, Shoukat, Irsa, Sosa, Hernando, Allingham, John S.

“…Kinesin-8s are dual-activity motor proteins that can move processively on microtubules and depolymerize microtubule plus-ends, but their mechanism of combining…”
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Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14 by Benoit, Matthieu P.M.H., Asenjo, Ana B., Paydar, Mohammadjavad, Dhakal, Sabin, Kwok, Benjamin H., Sosa, Hernando

“…KIF14 is a mitotic kinesin whose malfunction is associated with cerebral and renal developmental defects and several cancers. Like other kinesins, KIF14…”
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Kinesin-5 Promotes Microtubule Nucleation and Assembly by Stabilizing a Lattice-Competent Conformation of Tubulin by Chen, Geng-Yuan, Cleary, Joseph M., Asenjo, Ana B., Chen, Yalei, Mascaro, Jacob A., Arginteanu, David F.J., Sosa, Hernando, Hancock, William O.

“…Besides sliding apart antiparallel microtubules during spindle elongation, the mitotic kinesin-5, Eg5, promotes microtubule polymerization, emphasizing its…”
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mobile kinesin-head intermediate during the ATP-waiting state by Asenjo, Ana B, Sosa, Hernando

“…Kinesin1 is a motor protein that uses the energy from ATP hydrolysis to move intracellular cargoes along microtubules. It contains 2 identical motor domains,…”
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Structural Model for Tubulin Recognition and Deformation by Kinesin-13 Microtubule Depolymerases by Asenjo, Ana B., Chatterjee, Chandrima, Tan, Dongyan, DePaoli, Vania, Rice, William J., Diaz-Avalos, Ruben, Silvestry, Mariena, Sosa, Hernando

“…To elucidate the structural basis of the mechanism of microtubule depolymerization by kinesin-13s, we analyzed complexes of tubulin and the Drosophila…”
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KIF14 Binds Tightly to Microtubules and Adopts a Rigor-Like Conformation by Arora, Kritica, Talje, Lama, Asenjo, Ana B., Andersen, Parker, Atchia, Kaleem, Joshi, Monika, Sosa, Hernando, Allingham, John S., Kwok, Benjamin H.

“…The mitotic kinesin motor protein KIF14 is essential for cytokinesis during cell division and has been implicated in cerebral development and a variety of…”
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Author Correction: Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s by Benoit, Matthieu P. M. H., Asenjo, Ana B., Sosa, Hernando

“…The previously published version of this Article contained an error in Fig. 5. In panels f and g, the α and β symbols were swapped. The error has been…”
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Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6 by Ranaivoson, Fanomezana Moutse, Crozet, Vincent, Benoit, Matthieu P M H, Abdalla Mohammed Khalid, Amna, Kikuti, Carlos, Sirkia, Helena, El Marjou, Ahmed, Miserey-Lenkei, Stéphanie, Asenjo, Ana B, Sosa, Hernando, Schmidt, Christoph F, Rosenfeld, Steven S, Houdusse, Anne

“…KIF20A is a critical kinesin for cell division and a promising anti-cancer drug target. The mechanisms underlying its cellular roles remain elusive…”
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A second tubulin binding site on the kinesin-13 motor head domain is important during mitosis by Zhang, Dong, Asenjo, Ana B, Greenbaum, Michaela, Xie, Luping, Sharp, David J, Sosa, Hernando

“…Kinesin-13s are microtubule (MT) depolymerases different from most other kinesins that move along MTs. Like other kinesins, they have a motor or head domain…”
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Human Fidgetin is a microtubule severing the enzyme and minus-end depolymerase that regulates mitosis by Mukherjee, Suranjana, Valencia, J. Daniel Diaz, Stewman, Shannon, Metz, Jeremy, Monnier, Sylvain, Rath, Uttama, Asenjo, Ana B., Charafeddine, Rabab A., Sosa, Hernando J., Ross, Jennifer L., Ma, Ao, Sharp, David J.

“…Fidgetin is a member of the AAA protein superfamily with important roles in mammalian development. Here we show that human Fidgetin is a potent microtubule…”
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Distinct Interaction Modes of the Kinesin-13 Motor Domain with the Microtubule by Chatterjee, Chandrima, Benoit, Matthieu P.M.H., DePaoli, Vania, Diaz-Valencia, Juan D., Asenjo, Ana B., Gerfen, Gary J., Sharp, David J., Sosa, Hernando

“…Kinesins-13s are members of the kinesin superfamily of motor proteins that depolymerize microtubules (MTs) and have no motile activity. Instead of generating…”
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Kinesin-13s form rings around microtubules by Tan, Dongyan, Asenjo, Ana B, Mennella, Vito, Sharp, David J, Sosa, Hernando

“…Kinesin is a superfamily of motor proteins that uses the energy of adenosine triphosphate hydrolysis to move and generate force along microtubules. A notable…”
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Configuration of the two kinesin motor domains during ATP hydrolysis by Sosa, Hernando, Asenjo, Ana B, Krohn, Natan

“…To understand the mechanism of kinesin movement we have investigated the relative configuration of the two kinesin motor domains during ATP hydrolysis using…”
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Nucleotide binding and hydrolysis induces a disorder-order transition in the kinesin neck-linker region by Sosa, Hernando, Asenjo, Ana B, Weinberg, Yonatan

“…Kinesin translocation is thought to occur by a conformational change in a region of the motor domain called the neck linker. However, most evidence supporting…”
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Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration by Sharp, David J, Rath, Uttama, Riera, Tania, Diaz-Valencia, Juan Daniel, Ross, Jennifer L, Rogers, Stephen L, Currie, Joshua D, Liebling, Emily, Sosa, Hernando J, Ma, Ao, Stewman, Shannon F, Zhang, Dong, Buster, Daniel W, Grode, Kyle D, Asenjo, Ana B

“…The microtubule-severing protein Katanin is now shown to possess microtubule depolymerising activity. Purified recombinant Katanin exerts both activities in…”
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Design, chemical synthesis, and expression of genes for the three human color vision pigments by Oprian, Daniel D, Asenjo, Ana B, Lee, Ning, Pelletier, Sandra L

“…Color vision in humans is mediated by three pigments from retinal cone photoreceptor cells: blue, green, and red. We have designed and chemically synthesized…”
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Motor domain phosphorylation and regulation of the Drosophila kinesin 13, KLP10A by Mennella, Vito, Tan, Dong-Yan, Buster, Daniel W, Asenjo, Ana B, Rath, Uttama, Ma, Ao, Sosa, Hernando J, Sharp, David J

“…Microtubule (MT)-destabilizing kinesin 13s perform fundamental roles throughout the cell cycle. In this study, we show that the Drosophila melanogaster kinesin…”
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Molecular determinants of human red/green color discrimination by Asenjo, A B, Rim, J, Oprian, D D

“…The human red and green color vision pigments are identical at all but 15 of their 364 amino acids, and yet their absorption maxima differ by 31 nm. In an…”
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