Search Results - "Ase, Ariel R."

P2X receptor channels in chronic pain pathways by Bernier, Louis‐Philippe, Ase, Ariel R, Séguéla, Philippe

“…Chronic pain is a highly prevalent debilitating condition for which treatment options remain limited for many patients. Ionotropic ATP signalling through…”
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Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons by Sharif, Behrang, Ase, Ariel R., Ribeiro-da-Silva, Alfredo, Séguéla, Philippe

“…Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and…”
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Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers by Beaudry, Hélène, Daou, Ihab, Ase, Ariel R., Ribeiro-da-Silva, Alfredo, Séguéla, Philippe

“…Primary C-fiber nociceptors are broadly divided into peptidergic and nonpeptidergic afferents. TRPV1 is a thermosensitive cation channel mainly localized in…”
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Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels by Ase, Ariel R, Honson, Nicolette S, Zaghdane, Helmi, Pfeifer, Tom A, Séguéla, Philippe

“…P2X4 is an ATP-gated nonselective cation channel highly permeable to calcium. There is increasing evidence that this homomeric purinoceptor, which is expressed…”
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Remote optogenetic activation and sensitization of pain pathways in freely moving mice by Daou, Ihab, Tuttle, Alexander H, Longo, Geraldine, Wieskopf, Jeffrey S, Bonin, Robert P, Ase, Ariel R, Wood, John N, De Koninck, Yves, Ribeiro-da-Silva, Alfredo, Mogil, Jeffrey S, Séguéla, Philippe

“…We report a novel model in which remote activation of peripheral nociceptive pathways in transgenic mice is achieved optogenetically, without any external…”
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An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels by Ase, Ariel R, Therrien, Éric, Séguéla, Philippe

“…P2X receptors constitute a gene family of cation channels gated by extracellular ATP. They mediate fast ionotropic purinergic signaling in neurons and…”
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Contribution of TRPC3 to Store-Operated Calcium Entry and Inflammatory Transductions in Primary Nociceptors by Alkhani, Hazim, Ase, Ariel R, Grant, Rebecca, O'Donnell, Dajan, Groschner, Klaus, Séguéla, Philippe

“…Background: Prolonged intracellular calcium elevation contributes to sensitization of nociceptors and chronic pain in inflammatory conditions. The underlying…”
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Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain by Daou, Ihab, Beaudry, Hélène, Ase, Ariel R, Wieskopf, Jeffrey S, Ribeiro-da-Silva, Alfredo, Mogil, Jeffrey S, Séguéla, Philippe

“…We report a novel transgenic mouse model in which the terminals of peripheral nociceptors can be silenced optogenetically with high spatiotemporal precision,…”
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P2Y12 expression and function in alternatively activated human microglia by Moore, Craig S, Ase, Ariel R, Kinsara, Angham, Rao, Vijayaraghava T S, Michell-Robinson, Mackenzie, Leong, Soo Yuen, Butovsky, Oleg, Ludwin, Samuel K, Séguéla, Philippe, Bar-Or, Amit, Antel, Jack P

“…To investigate and measure the functional significance of altered P2Y12 expression in the context of human microglia activation. We performed in vitro and in…”
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P2X4 receptor channels form large noncytolytic pores in resting and activated microglia by Bernier, Louis-Philippe, Ase, Ariel R., Boué-Grabot, Éric, Séguéla, Philippe

“…P2X4 ATP‐gated cation channels have been shown to contribute to the microglial component of central sensitization, making their functional regulation a key…”
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Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels by Joch, Monica, Ase, Ariel R, Chen, Carol X-Q, MacDonald, Penny A, Kontogiannea, Maria, Corera, Amadou T, Brice, Alexis, Séguéla, Philippe, Fon, Edward A

“…Mutations in the parkin gene result in an autosomal recessive juvenile-onset form of Parkinson's disease. As an E3 ubiquitin-ligase, parkin promotes the…”
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Differential regulation of microglial P2X4 and P2X7 ATP receptors following LPS-induced activation by Raouf, Ramin, Chabot-Doré, Anne-Julie, Ase, Ariel R., Blais, Dominique, Séguéla, Philippe

“…Activation of microglia has been implicated in many neurological conditions including Alzheimer's disease and neuropathic pain. Recent studies provide evidence…”
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Distinct migratory and cytokine responses of human microglia and macrophages to ATP by Lambert, Caroline, Ase, Ariel R, Séguéla, Philippe, Antel, Jack P

“…Abstract Microglia and hematogenous myeloid cells are prominent components of inflammatory central nervous system (CNS) lesions associated with tissue injury…”
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Subtype-Specific Regulation of P2X3 and P2X2/3 Receptors by Phosphoinositides in Peripheral Nociceptors by Mo, Gary, Bernier, Louis-Philippe, Zhao, Qi, Chabot-Doré, Anne-Julie, Ase, Ariel R, Logothetis, Diomedes, Cao, Chang-Qing, Séguéla, Philippe

“…Background P2X3 and P2X2/3 purinergic receptor-channels, expressed in primary sensory neurons that mediate nociception, have been implicated in neuropathic and…”
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Direct modulation of P2X1 receptor-channels by the lipid phosphatidylinositol 4,5-bisphosphate by Bernier, Louis-Philippe, Ase, Ariel R, Tong, Xinkang, Hamel, Edith, Blais, Dominique, Zhao, Qi, Logothetis, Diomedes E, Séguéla, Philippe

“…The P2X(1) receptor-channels activated by extracellular ATP contribute to the neurogenic component of smooth muscle contraction in vascular beds and…”
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Characterization of Common Genetic Variants in P2RX7 and Their Contribution to Chronic Pain Conditions by Zorina-Lichtenwalter, Katerina, Ase, Ariel R, Verma, Vivek, Parra, Arturo I M, Komarova, Svetlana, Khadra, Anmar, Séguéla, Philippe, Diatchenko, Luda

“…The adenosine triphosphate (ATP)-gated channel P2X7 is encoded by a gene enriched for common nonsynonymous variants. Many of these variants have functional…”
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Potentiation of P2X1 ATP-gated currents by 5-hydroxytryptamine 2A receptors involves diacylglycerol-dependent kinases and intracellular calcium by Ase, Ariel R, Raouf, Ramin, Bélanger, Danny, Hamel, Edith, Séguéla, Philippe

“…Postsynaptic P2X1 ATP-gated channels are expressed in smooth muscle cells of the vascular and genitourinary systems, where they mediate desensitizing…”
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Altered Serotonin and Dopamine Metabolism in the CNS of Serotonin 5‐HT1A or 5‐HT1B Receptor Knockout Mice by Ase, Ariel R., Reader, Tomás A., Hen, René, Riad, Mustapha, Descarries, Laurent

“…: Measurements of serotonin (5‐HT), dopamine (DA), andnoradrenaline, and of 5‐HT and DA metabolites, were obtained by HPLC from 16brain regions and the spinal…”
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The CaV2α1 EF-hand F helix tyrosine, a highly conserved locus for GPCR inhibition of CaV2 channels by Dunn, Tyler W., Fan, Xiaotang, Ase, Ariel R., Séguéla, Philippe, Sossin, Wayne S.

“…The sensory neuron of Aplysia californica participates in several forms of presynaptic plasticity including homosynaptic depression, heterosynaptic depression,…”
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Inhibition of P2X4 function by P2Y6 UDP receptors in microglia by Bernier, Louis-Philippe, Ase, Ariel R., Boué-Grabot, Éric, Séguéla, Philippe

“…ATP‐gated P2X4 receptor channels expressed in spinal microglia actively participate in central sensitization, making their functional regulation a key process…”
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