Search Results - "Aschenbrenner, Laura M."

Sialidase-Based Anti-Influenza Virus Therapy Protects against Secondary Pneumococcal Infection by Hedlund, Maria, Aschenbrenner, Laura M., Jensen, Kellie, Larson, Jeffrey L., Fang, Fang

“…Background. DAS181 (Fludase) is a sialidase fusion protein in clinical development as a broad-spectrum anti-influenza virus (IFV) therapeutic agent. Previous…”
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Sialidase Fusion Protein as a Novel Broad-Spectrum Inhibitor of Influenza Virus Infection by MALAKHOV, Michael P, ASCHENBRENNER, Laura M, CAMPBELL, Erin R, MANG YU, FANG FANG, SMEE, Donald F, WANDERSEE, Miles K, SIDWELL, Robert W, GUBAREVA, Larisa V, MISHIN, Vasiliy P, HAYDEN, Frederick G, DO HYONG KIM, ING, Alice

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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DAS181, A Novel Sialidase Fusion Protein, Protects Mice from Lethal Avian Influenza H5N1 Virus Infection by Belser, Jessica A., Lu, Xiuhua, Szretter, Kristy J., Jin, Xiaoping, Aschenbrenner, Laura M., Lee, Alice, Hawley, Stephen, Kim, Do Hyong, Malakhov, Michael P., Yu, Mang, Fang, Fang, Katz, Jacqueline M.

“…Increasing resistance to currently available influenza antivirals highlights the need to develop alternate approaches for the prevention and/or treatment of…”
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Regulatory Experience Assessing the Carcinogenic Potential of a Monoclonal Antibody Inhibiting PCSK9, Bococizumab, Including a 2-Year Carcinogenicity Study in Rats by Buetow, Bernard S., Cappon, Gregg D, Aschenbrenner, Laura M., Updyke, Lawrence, Torti, Vince R., Evans, Mark, Dalton, Shana R., Bailey, Steven, Bowman, Christopher J.

“…Bococizumab is an anti-PCSK9 monoclonal antibody that was intended for the treatment of hypercholesterolemia. After reviewing the 6-month rat toxicity study…”
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Phenotypic and genotypic characterization of influenza virus mutants selected with the sialidase fusion protein DAS181 by TRIANA-BALTZER, Gallen B, SANDERS, Rebecca L, HEDLUND, Maria, JENSEN, Kellie A, ASCHENBRENNER, Laura M, LARSON, Jeffrey L, FANG FANG

“…influenza viruses (IFVs) frequently achieve resistance to antiviral drugs, necessitating the development of compounds with novel mechanisms of action. DAS181…”
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DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis by Triana-Baltzer, Gallen B., Babizki, Maria, Chan, Michael C. W., Wong, Adam C. N., Aschenbrenner, Laura M., Campbell, Erin R., Li, Qi-Xiang, Chan, Renee W. Y., Peiris, J. S. Malik, Nicholls, John M., Fang, Fang

“…Objectives The influenza virus (IFV) infection models commonly used to evaluate antiviral agents (e.g. MDCK cell line and mice) are limited by physiological…”
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A Safety Evaluation of DAS181, a Sialidase Fusion Protein, in Rodents by Larson, Jeffrey L., Kang, Seong-Kwi, Choi, Bo In, Hedlund, Maria, Aschenbrenner, Laura M., Cecil, Beth, Machado, GloriaMay, Nieder, Matthew, Fang, Fang

“…DAS181 is a novel inhaled drug candidate blocking influenza virus (IFV) and parainfluenza virus (PIV) infections through removal of sialic acid receptors from…”
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Comment on: Concerns of using sialidase fusion protein as an experimental drug to combat seasonal and pandemic influenza by Nicholls, John M., Aschenbrenner, Laura M., Paulson, James C., Campbell, Erin R., Malakhov, Michael P., Wurtman, David F., Yu, Mang, Fang, Fang

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Calcium Ion Downregulates Soluble Guanylyl Cyclase Activity: Evidence for a Two-metal Ion Catalytic Mechanism by Serfass, Lucile, Carr, Heather S., Aschenbrenner, Laura M., Burstyn, Judith N.

“…The inhibition of soluble guanylyl cyclase by Ca2+ has been kinetically characterized and the results support a two-metal-ion catalytic mechanism for formation…”
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