Search Results - "Aschenbach, Joerg R."

Microbial butyrate and its role for barrier function in the gastrointestinal tract by Plöger, Svenja, Stumpff, Friederike, Penner, Gregory B., Schulzke, Jörg-Dieter, Gäbel, Gotthold, Martens, Holger, Shen, Zanming, Günzel, Dorothee, Aschenbach, Joerg R.

“…Butyrate production in the large intestine and ruminant forestomach depends on bacterial butyryl‐CoA/acetate‐CoA transferase activity and is highest when…”
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PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases by Kolisek, Martin, Montezano, Augusto C, Sponder, Gerhard, Anagnostopoulou, Aikaterini, Vormann, Juergen, Touyz, Rhian M, Aschenbach, Joerg R

“…Disturbed magnesium (Mg(2+)) homoeostasis and increased levels of OS (oxidative stress) are associated with poor clinical outcomes in patients suffering from…”
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Relaxin-2 Does Not Ameliorate Nephropathy in an Experimental Model of Type-1 Diabetes by Dschietzig, Thomas Bernd, Krause-Relle, Katharina, Hennequin, Maud, von Websky, Karoline, Rahnenführer, Jan, Ruppert, Jana, Grön, Hans Jürgen, Armbruster, Franz Paul, Bathgate, Ross A. D., Aschenbach, Joerg R., Forssmann, Wolf-Georg, Hocher, Berthold

“…Background/Aims: In diabetic nephropathy (DN), the current angiotensin-II-blocking pharmacotherapy is frequently failing. For diabetic cardiomyopathy (DC),…”
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Regulation of intracellular Zn homeostasis in two intestinal epithelial cell models at various maturation time points by Gefeller, Eva-Maria, Bondzio, Angelika, Aschenbach, Jörg R, Martens, Holger, Einspanier, Ralf, Scharfen, Franziska, Zentek, Jürgen, Pieper, Robert, Lodemann, Ulrike

“…After weaning, piglets are often fed diets supplemented with high concentrations of zinc (Zn) to decrease post-weaning diarrhea. The aim of this study was to…”
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Symposium review: The importance of the ruminal epithelial barrier for a healthy and productive cow by Aschenbach, Jörg R, Zebeli, Qendrim, Patra, Amlan K, Greco, Gabriele, Amasheh, Salah, Penner, Gregory B

“…The stratified squamous ruminal epithelium is the main site for absorption of key nutrients (e.g., short-chain fatty acids; SCFA) and electrolytes (e.g.,…”
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Increased papillae growth and enhanced short-chain fatty acid absorption in the rumen of goats are associated with transient increases in cyclin D1 expression after ruminal butyrate infusion by Malhi, Moolchand, Gui, Hongbing, Yao, Lei, Aschenbach, Jörg R, Gäbel, Gotthold, Shen, Zanming

“…We tested the hypothesis that the proliferative effects of intraruminal butyrate infusions on the ruminal epithelium are linked to upregulation in cyclin D1…”
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Gastrointestinal methionine shuttle: Priority handling of precious goods by Mastrototaro, Lucia, Sponder, Gerhard, Saremi, Behnam, Aschenbach, Jörg R.

“…Methionine (Met) is a neutral, sulfur‐containing, essential amino acid with biological functions in the initiation and prolongation step of protein synthesis,…”
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Gluconeogenesis in dairy cows: The secret of making sweet milk from sour dough by Aschenbach, Jörg R., Kristensen, Niels B., Donkin, Shawn S., Hammon, Harald M., Penner, Gregory B.

“…Gluconeogenesis is a crucial process to support glucose homeostasis when nutritional supply with glucose is insufficient. Because ingested carbohydrates are…”
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Down-regulation of monocarboxylate transporter 1 (MCT1) gene expression in the colon of piglets is linked to bacterial protein fermentation and pro-inflammatory cytokine-mediated signalling by Villodre Tudela, Carmen, Boudry, Christelle, Stumpff, Friederike, Aschenbach, Jörg R., Vahjen, Wilfried, Zentek, Jürgen, Pieper, Robert

“…The present study investigated the influence of bacterial metabolites on monocarboxylate transporter 1 (MCT1) expression in pigs using in vivo, ex vivo and in…”
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Key role of short-chain fatty acids in epithelial barrier failure during ruminal acidosis by Meissner, Svenja, Hagen, Franziska, Deiner, Carolin, Günzel, Dorothee, Greco, Gabriele, Shen, Zanming, Aschenbach, Jörg R

“…Subacute ruminal acidosis is induced by high concentrations of short-chain fatty acids (SCFA, mainly acetate, propionate, and butyrate) that release protons to…”
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Claudin clusters as determinants of epithelial barrier function by Markov, Alexander G., Aschenbach, Jörg R., Amasheh, Salah

“…Claudins are tetraspan tight junction proteins which have been attributed to primarily determine epithelial barrier function in a wide variety of different…”
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Solute carrier 41A3 encodes for a mitochondrial Mg2+ efflux system by Mastrototaro, Lucia, Smorodchenko, Alina, Aschenbach, Jörg R., Kolisek, Martin, Sponder, Gerhard

“…The important role of magnesium (Mg 2+ ) in normal cellular physiology requires flexible, yet tightly regulated, intracellular Mg 2+ homeostasis (IMH)…”
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Campylobacter infection in chickens modulates the intestinal epithelial barrier function by Awad, Wageha A, Molnár, Andor, Aschenbach, Jörg R, Ghareeb, Khaled, Khayal, Basel, Hess, Claudia, Liebhart, Dieter, Dublecz, Károly, Hess, Michael

“…Asymptomatic carriage of Campylobacter jejuni is highly prevalent in chicken flocks. Thus, we investigated whether chronic Campylobacter carriage affects…”
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Insulin Modulates the Na+/Mg2+ Exchanger SLC41A1 and Influences Mg2+ Efflux from Intracellular Stores in Transgenic HEK293 Cells by Mastrototaro, Lucia, Tietjen, Uwe, Sponder, Gerhard, Vormann, Jürgen, Aschenbach, Jörg R, Kolisek, Martin

“…Magnesium deficiency is a common complication of diabetes with an unclear molecular background. We investigated the effect of the insulin (INS)-signaling…”
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Short-chain fatty acids and acidic pH upregulate UT-B, GPR41, and GPR4 in rumen epithelial cells of goats by Lu, Zhongyan, Gui, Hongbing, Yao, Lei, Yan, Lei, Martens, Holger, Aschenbach, Jörg R, Shen, Zanming

“…Currently, the mechanism(s) responsible for the regulation of urea transporter B (UT-B) expression levels in the epithelium of the rumen remain unclear. We…”
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The epithelial barrier and beyond: Claudins as amplifiers of physiological organ functions by Markov, Alexander G., Aschenbach, Jörg R., Amasheh, Salah

“…Epithelial cell layers are interconnected by a meshwork of tight junction (TJ) protein strands, which are localized within apicolateral membranes. The proteins…”
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Transport of Neutral Amino Acids in the Jejunum of Pigs with Special Consideration of L-Methionine by Schermuly, Isabel I, Romanet, Stella, Patra, Amlan K, Mastrototaro, Lucia, Lemme, Andreas, Pieper, Robert, Zentek, Jürgen, Aschenbach, Jörg R

“…Methionine (Met) is a popular nutritional supplement in humans and animals. It is routinely supplemented to pigs as L-Met, DL-Met, or…”
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Both monensin and plant extract alter ruminal fermentation in sheep but only monensin affects the expression of genes involved in acid-base transport of the ruminal epithelium by Mirzaei-Alamouti, Hamidreza, Moradi, Saeedeh, Shahalizadeh, Zahra, Razavian, Maryam, Amanlou, Hamid, Harkinezhad, Taher, Jafari-Anarkooli, Iraj, Deiner, Carolin, Aschenbach, Jörg R.

“…•Monensin and a commercial plant extract increase ruminal propionate production.•Only monensin affects the ruminal expression of acid-base…”
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Paracellular intestinal permeability of chickens induced by DON and/or C. jejuni is associated with alterations in tight junction mRNA expression by von Buchholz, J. Sophia, Ruhnau, Daniel, Hess, Claudia, Aschenbach, Jörg R., Hess, Michael, Awad, Wageha A.

“…Toxins, antigens, and harmful pathogens continuously challenge the intestinal mucosa. Therefore, regulation of the intestinal barrier is crucial for the…”
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Epithelial capacity for apical uptake of short chain fatty acids is a key determinant for intraruminal pH and the susceptibility to subacute ruminal acidosis in sheep by Penner, Gregory B, Aschenbach, Jörg R, Gäbel, Gotthold, Rackwitz, Reiko, Oba, Masahito

“…Subacute ruminal acidosis (SARA) is a common digestive disorder occurring in ruminants, with considerable variation in the severity of SARA observed among…”
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