Skeletal metastatic carcinoma: A case from 15th-20th century Coimbra, Portugal

Skeletal metastatic carcinoma: A case from 15th-20th century Coimbra, Portugal

This paper discusses the differential diagnosis of unusual and distinct pathological changes in the skeletal remains of a 40+‐year‐old female from 15th–20th century Coimbra (Portugal). The most affected area seems to have been the skull, but multiple lesions, lytic and/or blastic, have been found th...

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Bibliographic Details
Published in:International journal of osteoarchaeology Vol. 21; no. 3; pp. 336 - 346
Main Authors: Wasterlain, S. N., Ascenso, B. F., Silva, A. M.
Format: Journal Article
Language:English
Published: Chichester, UK John Wiley & Sons, Ltd 01-05-2011
Wiley Subscription Services, Inc
Subjects:
Archaeology
Breast cancer
cancer
Coimbra
Lung cancer
malignant tumour
Medical diagnosis
metastases
Metastasis
Musculoskeletal system
Portugal
Tumors
Coimbra Portugal
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Summary:This paper discusses the differential diagnosis of unusual and distinct pathological changes in the skeletal remains of a 40+‐year‐old female from 15th–20th century Coimbra (Portugal). The most affected area seems to have been the skull, but multiple lesions, lytic and/or blastic, have been found throughout the post‐cranial skeleton, more specifically in the scapulae, clavicles, humerus, sternum, ribs, sacrum, innominates and femurs. The differential diagnosis of the lesions gave rise to several possible pathological conditions, namely, Langerhans cell histiocytosis (granulomatosis or Histiocytosis X), multiple myeloma and metastatic carcinoma. Various macroscopic and radiological aspects lead us to consider metastatic carcinoma as the most probable diagnosis. Despite the argumentative identity of the possible primary lesion, age, sex and the mixed nature of the osseous response are consistent with cancer of the breast but do not exclude other carcinomas, namely lung cancer. With temporal and regional differences emerging in the frequency of malignant tumours, the identification of new cases becomes important, particularly from geographic areas where few cases have been reported. In fact, the present report adds to the only case of metastatic carcinoma detected in non‐identified Portuguese human skeletal remains until now. Copyright © 2009 John Wiley & Sons, Ltd.
Bibliography:istex:9CBAF54A609C3C8F2ED7682192000F925A6BA40A
ark:/67375/WNG-KKRHD8N7-D
ArticleID:OA1130
ISSN:1047-482X
1099-1212
DOI:10.1002/oa.1130