Age-related attenuation of conduit artery blood flow response to passive heating differs between the arm and leg

Purpose Little is known about why the attenuation of heat loss responses with aging begins in the lower limbs. This study sought to determine whether passive heating causes the age-related decrease and limb-specific difference of blood flow (BF) responses between conduit brachial and femoral arterie...

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Published in:	European journal of applied physiology Vol. 118; no. 11; pp. 2307 - 2318
Main Authors:	Oue, Anna, Asashima, Chie, Oizumi, Risa, Ichinose-Kuwahara, Tomoko, Kondo, Narihiko, Inoue, Yoshimitsu
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-11-2018 Springer Nature B.V
Subjects:	Age Age Factors Aged Aging Arm Arm - blood supply Arm - diagnostic imaging Biomedical and Life Sciences Biomedicine Blood flow Brachial Artery - diagnostic imaging Conductance Femoral artery Femoral Artery - diagnostic imaging Femur Forearm Heat loss Hot Temperature Human Physiology Humans Leg Leg - blood supply Leg - diagnostic imaging Limbs Male Middle Aged Occupational Medicine/Industrial Medicine Original Article Regional Blood Flow - physiology Relative humidity Skin - blood supply Sports Medicine Vasodilation - physiology Veins & arteries Young Adult Older males Skin blood flow Heat exposure Brachial artery blood flow Femoral artery blood flow
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Summary:	Purpose Little is known about why the attenuation of heat loss responses with aging begins in the lower limbs. This study sought to determine whether passive heating causes the age-related decrease and limb-specific difference of blood flow (BF) responses between conduit brachial and femoral arteries, which are related to differences of cutaneous vascular conductance (CVC) between the upper and lower limbs. Method In 15 older and 12 younger males, BF in the brachial and femoral arteries was ultrasonically measured and CVC in the forearm and thigh was assessed during lower leg immersion in hot water at 42 °C (ambient temperature: 30 °C, relative humidity: 45%) for 40 min. Results The increased BF of brachial artery at the end of passive heating was similar between both age groups (older: 140 ± 4%; younger: 146 ± 11%), while that of femoral artery was smaller in older than younger group (119 ± 4% vs. 166 ± 11%, P < 0.01). Moreover, the increased CVC in the forearm was similar between the age groups (older: 356 ± 50%; younger: 308 ± 46%), although CVC in the thigh was significantly lower in older than younger group (303 ± 33% vs. 427 ± 51%, P < 0.05). These results corresponded to the BF responses of the brachial and femoral arteries, respectively. Conclusion These results indicate that age-related decrease and limb-specific difference occur also in conduit arteries of arm and leg, which might be related to the different reduction in CVC between forearm and thigh.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1439-6319 1439-6327
DOI:	10.1007/s00421-018-3953-5