Search Results - "Asara, John"

A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue by Yuan, Min, Breitkopf, Susanne B, Yang, Xuemei, Asara, John M

“…The revival of interest in cancer cell metabolism in recent years has prompted the need for quantitative analytical platforms for studying metabolites from in…”
Get full text

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1 by Dibble, Christian C., Elis, Winfried, Menon, Suchithra, Qin, Wei, Klekota, Justin, Asara, John M., Finan, Peter M., Kwiatkowski, David J., Murphy, Leon O., Manning, Brendan D.

“…The tuberous sclerosis complex (TSC) tumor suppressors form the TSC1-TSC2 complex, which limits cell growth in response to poor growth conditions. Through its…”
Get full text

Systemic Organ Wasting Induced by Localized Expression of the Secreted Insulin/IGF Antagonist ImpL2 by Kwon, Young, Song, Wei, Droujinine, Ilia A., Hu, Yanhui, Asara, John M., Perrimon, Norbert

“…Organ wasting, related to changes in nutrition and metabolic activity of cells and tissues, is observed under conditions of starvation and in the context…”
Get full text

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals by Torrence, Margaret E, MacArthur, Michael R, Hosios, Aaron M, Valvezan, Alexander J, Asara, John M, Mitchell, James R, Manning, Brendan D

“…The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated anabolic program in response to growth-promoting signals. Paradoxically, recent…”
Get full text

Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer by Brown, Kristin K, Spinelli, Jessica B, Asara, John M, Toker, Alex

“…Chemotherapy resistance is a major barrier to the treatment of triple-negative breast cancer (TNBC), and strategies to circumvent resistance are required…”
Get more information

LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer by Saito, Yasuhiro, Li, Lewyn, Coyaud, Etienne, Luna, Augustin, Sander, Chris, Raught, Brian, Asara, John M., Brown, Myles, Muthuswamy, Senthil K.

“…Drosophila Lgl and its mammalian homologues, LLGL1 and LLGL2, are scaffolding proteins that regulate the establishment of apical–basal polarity in epithelial…”
Get full text

The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation by Lipton, Jonathan O., Yuan, Elizabeth D., Boyle, Lara M., Ebrahimi-Fakhari, Darius, Kwiatkowski, Erica, Nathan, Ashwin, Güttler, Thomas, Davis, Fred, Asara, John M., Sahin, Mustafa

“…The circadian timing system synchronizes cellular function by coordinating rhythmic transcription via a transcription-translational feedback loop. How the…”
Get full text

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates by Egan, Daniel F., Chun, Matthew G.H., Vamos, Mitchell, Zou, Haixia, Rong, Juan, Miller, Chad J., Lou, Hua Jane, Raveendra-Panickar, Dhanya, Yang, Chih-Cheng, Sheffler, Douglas J., Teriete, Peter, Asara, John M., Turk, Benjamin E., Cosford, Nicholas D.P., Shaw, Reuben J.

“…Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. ULK1/Atg1 is the…”
Get full text

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions by Guo, Jianping, Dai, Xiangpeng, Laurent, Benoit, Zheng, Nana, Gan, Wenjian, Zhang, Jian, Guo, Ailan, Yuan, Min, Liu, Pengda, Asara, John M., Toker, Alex, Shi, Yang, Pandolfi, Pier Paolo, Wei, Wenyi

“…Aberrant activation of AKT disturbs the proliferation, survival and metabolic homeostasis of various human cancers. Thus, it is critical to understand the…”
Get full text

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle by Ben-Sahra, Issam, Hoxhaj, Gerta, Ricoult, Stéphane J. H., Asara, John M., Manning, Brendan D.

“…In response to growth signals, mechanistic target of rapamycin complex 1 (mTORC1) stimulates anabolic processes underlying cell growth. We found that mTORC1…”
Get full text

Direct stimulation of NADP + synthesis through Akt-mediated phosphorylation of NAD kinase by Hoxhaj, Gerta, Ben-Sahra, Issam, Lockwood, Sophie E, Timson, Rebecca C, Byles, Vanessa, Henning, Graham T, Gao, Peng, Selfors, Laura M, Asara, John M, Manning, Brendan D

“…Nicotinamide adenine dinucleotide phosphate (NADP ) is essential for producing NADPH, the primary cofactor for reductive metabolism. We find that growth factor…”
Get full text

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1 by Ben-Sahra, Issam, Howell, Jessica J., Asara, John M., Manning, Brendan D.

“…Cellular growth signals stimulate anabolic processes. The mechanistic target of rapamycin complex 1 (mTORC1) is a protein kinase that senses growth signals to…”
Get full text

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression by Gan, Wenjian, Dai, Xiangpeng, Lunardi, Andrea, Li, Zhen, Inuzuka, Hiroyuki, Liu, Pengda, Varmeh, Shoreh, Zhang, Jinfang, Cheng, Liang, Sun, Yin, Asara, John M., Beck, Andrew H., Huang, Jiaoti, Pandolfi, Pier Paolo, Wei, Wenyi

“…The ERG gene is fused to TMPRSS2 in approximately 50% of prostate cancers (PrCa), resulting in its overexpression. However, whether this is the sole mechanism…”
Get full text

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton by Hu, Hai, Juvekar, Ashish, Lyssiotis, Costas A., Lien, Evan C., Albeck, John G., Oh, Doogie, Varma, Gopal, Hung, Yin Pun, Ullas, Soumya, Lauring, Josh, Seth, Pankaj, Lundquist, Mark R., Tolan, Dean R., Grant, Aaron K., Needleman, Daniel J., Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.

“…The phosphoinositide 3-kinase (PI3K) pathway regulates multiple steps in glucose metabolism and also cytoskeletal functions, such as cell movement and…”
Get full text

The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation by Ding, Jane, Li, Tai, Wang, Xiangwei, Zhao, Erhu, Choi, Jeong-Hyeon, Yang, Liqun, Zha, Yunhong, Dong, Zheng, Huang, Shuang, Asara, John M., Cui, Hongjuan, Ding, Han-Fei

“…Increased activation of the serine-glycine biosynthetic pathway is an integral part of cancer metabolism that drives macromolecule synthesis needed for cell…”
Get full text

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism by Ying, Haoqiang, Kimmelman, Alec C., Lyssiotis, Costas A., Hua, Sujun, Chu, Gerald C., Fletcher-Sananikone, Eliot, Locasale, Jason W., Son, Jaekyoung, Zhang, Hailei, Coloff, Jonathan L., Yan, Haiyan, Wang, Wei, Chen, Shujuan, Viale, Andrea, Zheng, Hongwu, Paik, Ji-hye, Lim, Carol, Guimaraes, Alexander R., Martin, Eric S., Chang, Jeffery, Hezel, Aram F., Perry, Samuel R., Hu, Jian, Gan, Boyi, Xiao, Yonghong, Asara, John M., Weissleder, Ralph, Wang, Y. Alan, Chin, Lynda, Cantley, Lewis C., DePinho, Ronald A.

“…Tumor maintenance relies on continued activity of driver oncogenes, although their rate-limiting role is highly context dependent. Oncogenic Kras mutation is…”
Get full text

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS by Yuan, Min, Kremer, Daniel M., Huang, He, Breitkopf, Susanne B., Ben-Sahra, Issam, Manning, Brendan D., Lyssiotis, Costas A., Asara, John M.

“…Targeted tandem mass spectrometry (LC–MS/MS) has been extremely useful for profiling small molecules extracted from biological sources, such as cells, bodily…”
Get full text

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein by DeRan, Michael, Yang, Jiayi, Shen, Che-Hung, Peters, Eric C., Fitamant, Julien, Chan, Puiyee, Hsieh, Mindy, Zhu, Shunying, Asara, John M., Zheng, Bin, Bardeesy, Nabeel, Liu, Jun, Wu, Xu

“…Hippo signaling is a tumor-suppressor pathway involved in organ size control and tumorigenesis through the inhibition of YAP and TAZ. Here, we show that energy…”
Get full text

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency by Zhang, Jin, Ratanasirintrawoot, Sutheera, Chandrasekaran, Sriram, Wu, Zhaoting, Ficarro, Scott B., Yu, Chunxiao, Ross, Christian A., Cacchiarelli, Davide, Xia, Qing, Seligson, Marc, Shinoda, Gen, Xie, Wen, Cahan, Patrick, Wang, Longfei, Ng, Shyh-Chang, Tintara, Supisara, Trapnell, Cole, Onder, Tamer, Loh, Yuin-Han, Mikkelsen, Tarjei, Sliz, Piotr, Teitell, Michael A., Asara, John M., Marto, Jarrod A., Li, Hu, Collins, James J., Daley, George Q.

“…The RNA-binding proteins LIN28A and LIN28B play critical roles in embryonic development, tumorigenesis, and pluripotency, but their exact functions are poorly…”
Get full text

Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1 by Dibble, Christian C., Asara, John M., Manning, Brendan D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text