Search Results - "Asara, J. M."

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix by Glavey, S V, Naba, A, Manier, S, Clauser, K, Tahri, S, Park, J, Reagan, M R, Moschetta, M, Mishima, Y, Gambella, M, Rocci, A, Sacco, A, O'Dwyer, M E, Asara, J M, Palumbo, A, Roccaro, A M, Hynes, R O, Ghobrial, I M

“…The extracellular matrix (ECM) is a major component of the tumor microenvironment, contributing to the regulation of cell survival, proliferation,…”
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Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT by Zheng, Y, Gierut, J, Wang, Z, Miao, J, Asara, J M, Tyner, A L

“…Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase expressed in epithelial cancers. Disruption of Ptk6 decreases azoxymethane-induced colon…”
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Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response by Lall, R, Ganapathy, S, Yang, M, Xiao, S, Xu, T, Su, H, Shadfan, M, Asara, J M, Ha, C S, Ben-Sahra, I, Manning, B D, Little, J B, Yuan, Z-M

“…Because of insufficient understanding of the molecular effects of low levels of radiation exposure, there is a great uncertainty regarding its health risks. We…”
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Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis by Oaks, Z., Patel, A., Huang, N., Choudhary, G., Winans, T., Faludi, T., Krakko, D., Duarte, M., Lewis, J., Beckford, M., Blair, S., Kelly, R., Landas, S. K., Middleton, F. A., Asara, J. M., Chung, S. K., Fernandez, D. R., Banki, K., Perl, A.

“…Oxidative stress modulates carcinogenesis in the liver; however, direct evidence for metabolic control of oxidative stress during pathogenesis, particularly,…”
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In vitro model suggests oxidative stress involved in keratoconus disease by Karamichos, D., Hutcheon, A. E. K., Rich, C. B., Trinkaus-Randall, V., Asara, J. M., Zieske, J. D.

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Time-dependent metabolomic profiling of Ketamine drug action reveals hippocampal pathway alterations and biomarker candidates by Weckmann, K, Labermaier, C, Asara, J M, Müller, M B, Turck, C W

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Enhanced detection of phosphopeptides in matrix-assisted laser desorption/ionization mass spectrometry using ammonium salts by Asara, John M., Allison, John

“…Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) has been used successfully to detect phosphorylation sites in proteins. Applications…”
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Data pre-processing in liquid chromatography–mass spectrometry-based proteomics by Zhang, Xiang, Asara, John M., Adamec, Jiri, Ouzzani, Mourad, Elmagarmid, Ahmed K.

“…Motivation: In a liquid chromatography–mass spectrometry (LC–MS)-based expressional proteomics, multiple samples from different groups are analyzed in…”
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In vitro model suggests oxidative stress involved in keratoconus disease by Karamichos, D., Hutcheon, A. E. K., Rich, C. B., Trinkaus-Randall, V., Asara, J. M., Zieske, J. D.

“…Keratoconus (KC) affects 1:2000 people and is a disorder where cornea thins and assumes a conical shape. Advanced KC requires surgery to maintain vision. The…”
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mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency by Winans, T., Oaks, Z., Choudhary, G., Patel, A., Huang, N., Faludi, T., Krakko, D., Nolan, J., Lewis, J., Blair, Sarah, Lai, Z., Landas, S.K., Middleton, F., Asara, J.M., Chung, S.K., Wyman, B., Azadi, P., Banki, K., Perl, A.

“…Transaldolase deficiency predisposes to chronic liver disease progressing from cirrhosis to hepatocellular carcinoma (HCC). Transition from cirrhosis to…”
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Recombinant Brassinosteroid Insensitive 1 Receptor-like Kinase Autophosphorylates on Serine and Threonine Residues and Phosphorylates a Conserved Peptide Motif In vitro by Man-Ho Oh, William K. Ray, Huber, Steven C., Asara, John M., Gage, Douglas A., Clouse, Steven D.

“…BRASSINOSTEROID-INSENSITIVE 1 (BRI1) encodes a putative Leucine-rich repeat receptor kinase in Arabidopsis that has been shown by genetic and molecular…”
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Quercetin Attenuates Lactate Production and Extracellular Matrix Secretion in Keratoconus by McKay, T. B., Lyon, D., Sarker-Nag, A., Priyadarsini, S., Asara, J. M., Karamichos, D.

“…Keratoconus(KC) is an ecstatic corneal disease leading to corneal-thinning and the formation of a cone-like cornea. Elevated lactate levels, increased…”
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Time-dependent metabolomic profiling of Ketamine drug action reveals hippocampal pathway alterations and biomarker candidates by Weckmann, K, Labermaier, C, Asara, J M, Müller, M B, Turck, C W

“…Ketamine, an N -methyl- D -aspartate receptor (NMDAR) antagonist, has fast-acting antidepressant activities and is used for major depressive disorder (MDD)…”
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Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin–proteasome systems by Park, D I, Dournes, C, Sillaber, I, Ising, M, Asara, J M, Webhofer, C, Filiou, M D, Müller, M B, Turck, C W

“…The aim of this study was to identify molecular pathways related to antidepressant response. We administered paroxetine to the DBA/2J mice for 28 days…”
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Enhanced Detection of Oligonucleotides in UV MALDI MS Using the Tetraamine Spermine as a Matrix Additive by Asara, John M, Allison, John

“…Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) has been used to analyze oligonucleotides. However, success has been limited by cation…”
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Publisher Correction: Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis by Oaks, Z., Patel, A., Huang, N., Choudhary, G., Winans, T., Faludi, T., Krakko, D., Duarte, M., Lewis, J., Beckford, M., Blair, S., Kelly, R., Landas, S. K., Middleton, F. A., Asara, J. M., Chung, S. K., Fernandez, D. R., Banki, K., Perl, A.

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Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation by Sano, Hiroyuki, Kane, Susan, Sano, Eiko, Mı̂inea, Cristinel P., Asara, John M., Lane, William S., Garner, Charles W., Lienhard, Gustav E.

“…Insulin stimulates the rapid translocation of intracellular glucose transporters of the GLUT4 isotype to the plasma membrane in fat and muscle cells. The…”
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Evidence for Binding of Dirhodium Bis-Acetate Units to Adjacent GG and AA Sites on Single-Stranded DNA by Asara, John M, Hess, Jennifer S, Lozada, Elizabeth, Dunbar, Kim R, Allison, John

“…Dirhodium tetraacetate is an antitumor active compound that is known to inhibit cellular DNA synthesis, but relatively little is known about its interactions…”
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Centriole distal appendages promote membrane docking, leading to cilia initiation by Tanos, Barbara E, Yang, Hui-Ju, Soni, Rajesh, Wang, Won-Jing, Macaluso, Frank P, Asara, John M, Tsou, Meng-Fu Bryan

“…The distal appendages (DAPs) of centrioles have been proposed to anchor cilia to the plasma membrane, but their molecular composition, assembly, and exact…”
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Hifα targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing by IVAN, Mircea, KONDO, Keiichi, YANG, Haifeng, KIM, William, VALIANDO, Jennifer, OHH, Michael, SALIC, Adrian, ASARA, John M, LANE, William S, KAELIN, William G

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