Search Results - "Asaoka, Tadafumi"

MicroRNA-155 Controls Exosome Synthesis and Promotes Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma by Mikamori, Manabu, Yamada, Daisaku, Eguchi, Hidetoshi, Hasegawa, Shinichiro, Kishimoto, Tomoya, Tomimaru, Yoshito, Asaoka, Tadafumi, Noda, Takehiro, Wada, Hiroshi, Kawamoto, Koichi, Gotoh, Kunihito, Takeda, Yutaka, Tanemura, Masahiro, Mori, Masaki, Doki, Yuichiro

“…The cancer drug gemcitabine (GEM) is a key drug for treating pancreatic ductal adenocarcinoma (PDAC), but PDAC cells develop chemoresistance after long-term…”
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Impact of CD36 on Chemoresistance in Pancreatic Ductal Adenocarcinoma by Kubo, Masahiko, Gotoh, Kunihito, Eguchi, Hidetoshi, Kobayashi, Shogo, Iwagami, Yoshifumi, Tomimaru, Yoshito, Akita, Hirofumi, Asaoka, Tadafumi, Noda, Takehiro, Takeda, Yutaka, Tanemura, Masahiro, Mori, Masaki, Doki, Yuichiro

“…Background CD36, a multi-ligand scavenger receptor, has been associated with several cancers. Many studies have revealed that CD36 contributed to cancer…”
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Endogenous CXCL9 affects prognosis by regulating tumor‐infiltrating natural killer cells in intrahepatic cholangiocarcinoma by Fukuda, Yasunari, Asaoka, Tadafumi, Eguchi, Hidetoshi, Yokota, Yuki, Kubo, Masahiko, Kinoshita, Mitsuru, Urakawa, Shinya, Iwagami, Yoshifumi, Tomimaru, Yoshito, Akita, Hirofumi, Noda, Takehiro, Gotoh, Kunihito, Kobayashi, Shogo, Hirata, Michinari, Wada, Hisashi, Mori, Masaki, Doki, Yuichiro

“…CXCL9, an IFN‐γ inducible chemokine, has been reported to play versatile roles in tumor‐host interrelationships. However, little is known about its role in…”
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Exosomal miR-155 Derived from Hepatocellular Carcinoma Cells Under Hypoxia Promotes Angiogenesis in Endothelial Cells by Matsuura, Yusuke, Wada, Hiroshi, Eguchi, Hidetoshi, Gotoh, Kunihito, Kobayashi, Shogo, Kinoshita, Mitsuru, Kubo, Masahiko, Hayashi, Koji, Iwagami, Yoshifumi, Yamada, Daisaku, Asaoka, Tadafumi, Noda, Takehiro, Kawamoto, Koichi, Takeda, Yutaka, Tanemura, Masahiro, Umeshita, Koji, Doki, Yuichiro, Mori, Masaki

“…Purpose In this study, we aim to clarify whether exosomes secreted from hepatocellular carcinoma (HCC) cells under hypoxia affect angiogenesis in endothelial…”
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Selection criteria for hepatic resection in intermediate-stage (BCLC stage B) multiple hepatocellular carcinoma by Wada, Hiroshi, MD, PhD, Eguchi, Hidetoshi, MD, PhD, Noda, Takehiro, MD, PhD, Ogawa, Hisataka, MD, PhD, Yamada, Daisaku, MD, PhD, Tomimaru, Yoshito, MD, PhD, Tomokuni, Akira, MD, PhD, Asaoka, Tadafumi, MD, PhD, Kawamoto, Koichi, MD, PhD, Gotoh, Kunihito, MD, PhD, Marubashi, Shigeru, MD, PhD, Umeshita, Koji, MD, PhD, Nagano, Hiroaki, MD, PhD, Doki, Yuichiro, MD, PhD, Mori, Masaki, MD, PhD

“…Background Several reports have suggested that hepatic resection provides a survival benefit in patients with hepatocellular carcinoma (HCC) at the…”
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Construction of three-dimensional vascularized functional human liver tissue using a layer-by-layer cell coating technique by Sasaki, Kazuki, Akagi, Takami, Asaoka, Tadafumi, Eguchi, Hidetoshi, Fukuda, Yasunari, Iwagami, Yoshifumi, Yamada, Daisaku, Noda, Takehiro, Wada, Hiroshi, Gotoh, Kunihito, Kawamoto, Koichi, Doki, Yuichiro, Mori, Masaki, Akashi, Mitsuru

“…Abstract The creation of artificial liver tissue is an active area of research due to the shortage of donors for liver transplantation. Here we investigated…”
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Long-term outcomes of single-incision versus multiport laparoscopic colectomy for colon cancer: results of a propensity score-based analysis by Suzuki, Yozo, Tei, Mitsuyoshi, Wakasugi, Masaki, Nakahara, Yujiro, Naito, Atsushi, Mikamori, Manabu, Furukawa, Kenta, Ohtsuka, Masahisa, Moon, Jeong Ho, Imasato, Mitsunobu, Asaoka, Tadafumi, Kishi, Kentaro, Akamatsu, Hiroki

“…Background Long-term outcomes of single-incision laparoscopic colectomy (SILC) for colon cancer (CC), as practiced in real-world settings, especially in…”
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Tumor endothelial cell‐induced CD8+ T‐cell exhaustion via GPNMB in hepatocellular carcinoma by Sakano, Yoshihiro, Noda, Takehiro, Kobayashi, Shogo, Sasaki, Kazuki, Iwagami, Yoshifumi, Yamada, Daisaku, Tomimaru, Yoshito, Akita, Hirofumi, Gotoh, Kunihito, Takahashi, Hidenori, Asaoka, Tadafumi, Tanemura, Masahiro, Wada, Hisashi, Doki, Yuichiro, Eguchi, Hidetoshi

“…Tumor endothelial cells (TECs) promote tumor angiogenesis and regulate cytotoxic T cells in the tumor microenvironment. However, the roles of TECs for…”
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Clinical impact of high-quality testing for peritoneal lavage cytology in pancreatic cancer by Tanemura, Masahiro, Furukawa, Kenta, Mikamori, Manabu, Asaoka, Tadafumi, Yasuoka, Hironao, Marukawa, Daiki, Urata, Yasuo, Yamada, Daisaku, Kobayashi, Shogo, Eguchi, Hidetoshi

“…In pancreatic ductal adenocarcinoma (PDAC) patients, the importance of peritoneal lavage cytology, which indicates unresectability, remains controversial. This…”
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MicroRNA-26a-5p is a reliable biomarker in the adjuvant setting for pancreatic ductal adenocarcinoma by Takeda, Yu, Yamada, Daisaku, Kobayashi, Shogo, Sasaki, Kazuki, Iwagami, Yoshifumi, Tomimaru, Yoshito, Noda, Takehiro, Takahashi, Hidenori, Asaoka, Tadafumi, Shimizu, Junzo, Doki, Yuichiro, Eguchi, Hidetoshi

“…Pancreatic ductal adenocarcinoma (PDAC) has a high recurrence rate even after radical resection because of subclinical tumors. To manage them, a reliable…”
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Heterogeneity of Treg/Th17 According to Cancer Progression and Modification in Biliary Tract Cancers via Self-Producing Cytokines by Kinoshita, Mitsuru, Kobayashi, Shogo, Gotoh, Kunihito, Kubo, Masahiko, Hayashi, Koji, Iwagami, Yoshifumi, Yamada, Daisaku, Akita, Hirofumi, Noda, Takehiro, Asaoka, Tadafumi, Takeda, Yutaka, Tanemura, Masahiro, Eguchi, Hidetoshi, Urakawa, Shinya, Goto, Kumiko, Maekawa, Kayoko, Wada, Hisashi, Mori, Masaki, Doki, Yuichiro

“…Background/Aim We previously demonstrated that inflammatory cytokine interleukin-6 (IL-6) was produced during cancer progression, worked together with…”
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Clinical significance of preoperative CA19-9 and lymph node metastasis in intrahepatic cholangiocarcinoma by Asaoka, Tadafumi, Kobayashi, Shogo, Hanaki, Takehiko, Iwagami, Yoshifumi, Tomimaru, Yoshito, Akita, Hirofumi, Noda, Takehiro, Gotoh, Kunihito, Takeda, Yutaka, Tanemura, Masahiro, Doki, Yuichiro, Eguchi, Hidetoshi

“…Purpose This study aimed to identify prognostic factors for patients with ICC after a curative resection and clarify the appropriate indications for surgical…”
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Prognostic impact of preoperative NLR and CA19-9 in pancreatic cancer by Asaoka, Tadafumi, Miyamoto, Atsushi, Maeda, Sakae, Tsujie, Masanori, Hama, Naoki, Yamamoto, Kazuyoshi, Miyake, Masakazu, Haraguchi, Naotsugu, Nishikawa, Kazuhiro, Hirao, Motohiro, Ikeda, Masataka, Sekimoto, Mitsugu, Nakamori, Shoji

“…Abstract Background Recently, several preoperative proinflammatory markers and nutritional factors such as neutrophil-to-lymphocyte ratio (NLR) and prognostic…”
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Epithelial‐mesenchymal transition via transforming growth factor beta in pancreatic cancer is potentiated by the inflammatory glycoprotein leucine‐rich alpha‐2 glycoprotein by Otsuru, Toru, Kobayashi, Shogo, Wada, Hiroshi, Takahashi, Tsuyoshi, Gotoh, Kunihito, Iwagami, Yoshifumi, Yamada, Daisaku, Noda, Takehiro, Asaoka, Tadafumi, Serada, Satoshi, Fujimoto, Minoru, Eguchi, Hidetoshi, Mori, Masaki, Doki, Yuichiro, Naka, Testuji

“…We previously showed that an inflammation‐related, molecule leucine‐rich alpha‐2 glycoprotein (LRG) enhances the transforming growth factor (TGF)‐β1‐induced…”
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Role of histone deacetylase 1 in distant metastasis of pancreatic ductal cancer by Shinke, Go, Yamada, Daisaku, Eguchi, Hidetoshi, Iwagami, Yoshifumi, Asaoka, Tadafumi, Noda, Takehiro, Wada, Hiroshi, Kawamoto, Koichi, Gotoh, Kunihito, Kobayashi, Shogo, Takeda, Yutaka, Tanemura, Masahiro, Mori, Masaki, Doki, Yuichiro

“…Current therapies for pancreatic ductal cancer (PDAC) do not sufficiently control distant metastasis. Thus, new therapeutic targets are urgently needed…”
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Short-term surgical outcomes of minimally invasive repeat hepatectomy for recurrent liver cancer by Noda, Takehiro, Eguchi, Hidetoshi, Wada, Hiroshi, Iwagami, Yoshifumi, Yamada, Daisaku, Asaoka, Tadafumi, Gotoh, Kunihito, Kawamoto, Koichi, Takeda, Yutaka, Tanemura, Masahiro, Umeshita, Koji, Doki, Yuichiro, Mori, Masaki

“…Background Repeat liver resection is an effective treatment, with long-term surgical outcomes for recurrent hepatocellular carcinoma and colorectal liver…”
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MicroRNA‐181b‐5p, ETS1, and the c‐Met pathway exacerbate the prognosis of pancreatic ductal adenocarcinoma after radiation therapy by Tomihara, Hideo, Yamada, Daisaku, Eguchi, Hidetoshi, Iwagami, Yoshifumi, Noda, Takehiro, Asaoka, Tadafumi, Wada, Hiroshi, Kawamoto, Koichi, Gotoh, Kunihito, Takeda, Yutaka, Tanemura, Masahiro, Mori, Masaki, Doki, Yuichiro

“…Preoperative chemoradiation therapy (CRT) for pancreatic ductal adenocarcinoma (PDAC) has emerged as a reasonable strategy that shows good prognostic impact…”
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Inhibition of Clusterin Represses Proliferation by Inducing Cellular Senescence in Pancreatic Cancer by Mitsufuji, Suguru, Iwagami, Yoshifumi, Kobayashi, Shogo, Sasaki, Kazuki, Yamada, Daisaku, Tomimaru, Yoshito, Akita, Hirofumi, Asaoka, Tadafumi, Noda, Takehiro, Gotoh, Kunihito, Takahashi, Hidenori, Tanemura, Masahiro, Doki, Yuichiro, Eguchi, Hidetoshi

“…Background The outcome of pancreatic ductal adenocarcinoma (PDAC) is unsatisfactory, and the identification of novel therapeutic targets is urgently needed…”
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CT Density in the Pancreas is a Promising Imaging Predictor for Pancreatic Ductal Adenocarcinoma by Fukuda, Yasunari, Yamada, Daisaku, Eguchi, Hidetoshi, Hata, Tomoki, Iwagami, Yoshifumi, Noda, Takehiro, Asaoka, Tadafumi, Kawamoto, Koichi, Gotoh, Kunihito, Kobayashi, Shogo, Takeda, Yutaka, Tanemura, Masahiro, Mori, Masaki, Doki, Yuichiro

“…Background Fatty pancreas (FP) was recently recognized as a risk factor for pancreatic ductal adenocarcinoma (PDAC). It is unclear whether computed tomography…”
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ACAT-1-Regulated Cholesteryl Ester Accumulation Modulates Gemcitabine Resistance in Biliary Tract Cancer by Ueno, Goro, Iwagami, Yoshifumi, Kobayashi, Shogo, Mitsufuji, Suguru, Yamada, Daisaku, Tomimaru, Yoshito, Akita, Hirofumi, Asaoka, Tadafumi, Noda, Takehiro, Gotoh, Kunihito, Mori, Masaki, Doki, Yuichiro, Eguchi, Hidetoshi

“…Background Biliary tract cancer (BTC) has few choices of chemotherapy, including gemcitabine, therefore exploring the mechanisms of gemcitabine resistance is…”
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