Para-Aortic Lymphadenectomy and Subsequent Chemotherapy after Resection of the Primary Lesion for Poorly Differentiated Adenocarcinoma of the Sigmoid Colon - A Case Report

The patient was a 68-year-old male who had bloody stools. A colonoscopy revealed a sigmoid colon stricture, and a histological examination confirmed the presence of a poorly differentiated adenocarcinoma.Computed tomography revealed the involvement of a para-aortic lymph nodes, without other metasta...

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Bibliographic Details
Published in:	Gan to kagaku ryoho Vol. 42; no. 11; p. 1435
Main Authors:	Kuribara, Tadao, Ichikawa, Tatsuo, Kaneko, Shiori, Osa, Kiyoshi, Ueda, Mamoru, Inoue, Takeshi, Asanuma, Kouzou, Sano, Takayuki, Kishimoto, Yutaka, Ishizu, Hideki, Iai, Akira
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-11-2015
Subjects:	Adenocarcinoma - drug therapy Adenocarcinoma - surgery Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Aorta - pathology Chemotherapy, Adjuvant Fluorouracil - therapeutic use Humans Leucovorin - therapeutic use Lymph Node Excision Male Organoplatinum Compounds - therapeutic use Recurrence Sigmoid Neoplasms - drug therapy Sigmoid Neoplasms - pathology Sigmoid Neoplasms - surgery Tomography, X-Ray Computed Treatment Outcome
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Summary:	The patient was a 68-year-old male who had bloody stools. A colonoscopy revealed a sigmoid colon stricture, and a histological examination confirmed the presence of a poorly differentiated adenocarcinoma.Computed tomography revealed the involvement of a para-aortic lymph nodes, without other metastatic lesions. The patient underwent a sigmoidectomy (with regional lymph node dissection) and a para-aortic lymph node biopsy to prove the histological conformation. Subsequently, he was provided with 6 courses of modified FOLFOX6(mFOLFOX6) chemotherapy, resulting in a marked decrease in para-aortic lymph node involvement. He subsequently underwent a para-aortic lymphadenectomy. The resected specimen was mostly composed of fibrous degenerative tissue; viable cancer cells were observed only in a 2-mm² area. The patient was provided with 6 more courses of mFOLFOX6 chemotherapy, and has since been free of recurrence (for 6 years and 1 month after the second surgery).
ISSN:	0385-0684