TREM-1 as a Marker of Multiple Organ Failure in Cardiac Surgery

Systemic inflammatory response syndrome (SIRS) frequently accompanies early postoperative period after cardiac surgery and in some cases is complicated by multiple organ failure (MOF). Inherited variation in the innate immune response genes (e.g., TREM1) is among the major factors determining the de...

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Bibliographic Details
Published in:	Immunological investigations Vol. 52; no. 5; pp. 583 - 597
Main Authors:	Khutornaya, Maria V., Sinitsky, Maxim Yu, Sinitskaya, Anna V., Asanov, Maxim А., Ponasenko, Anastasia V., Grigoriev, Evgeny V.
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 04-07-2023
Subjects:	Coronary artery disease innate immunity multiple organ failure sTREM-1 TREM1 multiple organ failure sTREM-1 innate immunity Coronary artery disease TREM1
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Summary:	Systemic inflammatory response syndrome (SIRS) frequently accompanies early postoperative period after cardiac surgery and in some cases is complicated by multiple organ failure (MOF). Inherited variation in the innate immune response genes (e.g., TREM1) is among the major factors determining the development of SIRS and the risk of MOF. This research was aimed to study whether the polymorphisms within the TREM1 gene are associated with MOF after the coronary artery bypass graft (CABG) surgery. Here we enrolled 592 patients who underwent CABG surgery in the Research Institute for Complex Issues of Cardiovascular Diseases (Kemerovo, Russia) and documented 28 cases of MOF. Genotyping was performed by allele-specific PCR using TaqMan probes. In addition, we measured serum soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) using enzyme-linked immunosorbent assay. Five polymorphisms (rs1817537, rs2234246, rs3804277, rs7768162 andrs4711668) within the TREM1 gene were significantly associated with MOF. Patients with MOF had higher serum sTREM-1 as compared with those without MOF at both pre- and post-intervention stages. Serum sTREM-1 was associated with the rs1817537,rs2234246 and rs3804277 polymorphisms within the TREM1 gene. Minor alleles within the TREM1 gene define the level of serum sTREM-1 and are associated with MOF after CABG surgery.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0882-0139 1532-4311
DOI:	10.1080/08820139.2023.2215276