Search Results - "Asano, Junichi"

Master protocol trials in oncology: Review and new trial designs by Hirakawa, Akihiro, Asano, Junichi, Sato, Hiroyuki, Teramukai, Satoshi

“…AbstractIn oncology, next generation sequencing and comprehensive genomic profiling have enabled the detailed classification of tumors using molecular biology…”
Get full text

Practical basket design for binary outcomes with control of family-wise error rate by Asano, Junichi, Sato, Hiroyuki, Hirakawa, Akihiro

“…A basket trial is a type of clinical trial in which eligibility is based on the presence of specific molecular characteristics across subpopulations with…”
Get full text

A Bayesian basket trial design accounting for uncertainties of homogeneity and heterogeneity of treatment effect among subpopulations by Asano, Junichi, Hirakawa, Akihiro

“…Summary Basket trials are a recent and innovative approach in oncological clinical trial design. A basket trial is a type of clinical trial for which…”
Get full text

Isolation of High-Purity Betanin from Red Beet and Elucidation of Its Antioxidant Activity against Peroxynitrite: An in vitro Study by Sakihama, Yasuko, Kato, Takashi, Sawatdee, Sopanat, Yakushi, Yo, Asano, Junichi, Hayashi, Hiroyo, Goto, Yuya, Hashimoto, Makoto, Hashidoko, Yasuyuki

“…Reactive oxygen species and reactive nitrogen species (RNS) are damaging for many biomolecules. Peroxynitrite (ONOO−) is the most toxic molecular species among…”
Get full text

Assessment of the impact of Japanese‐specific long‐term safety data on new drug approval by Uzu, Shinobu, Sekine, Shohko, Asano, Junichi, Ikuma, Mutsuhiro

“…Under the International Council for Harmonization (ICH)‐E1 guideline for drugs intended for chronic or repeated intermittent use in non‐life‐threatening…”
Get full text

Use of Cox’s Cure Model to Establish Clinical Determinants of Long-Term Disease-Free Survival in Neoadjuvant-Chemotherapy-Treated Breast Cancer Patients without Pathologic Complete Response by Hamada, Chikuma, Yonemori, Kan, Hirata, Taizo, Shimizu, Chikako, Tamura, Kenji, Fujiwara, Yasuhiro, Asano, Junichi, Hirakawa, Akihiro

“…In prognostic studies for breast cancer patients treated with neoadjuvant chemotherapy (NAC), the ordinary Cox proportional-hazards (PH) model has been often…”
Get full text

Regulatory Issues: PMDA – Review of Sakigake Designation Products: Oncolytic Virus Therapy with Delytact Injection (Teserpaturev) for Malignant Glioma by Maruyama, Yoshiaki, Sakurai, Akira, Noda, Shinichi, Fujiwara, Yasuhiro, Okura, Narumi, Takagi, Toshinori, Asano, Junichi, Honda, Futaba

“…Abstract In June 2021, the Ministry of Health, Labor and Welfare approved Delytact Injection as a regenerative medical product for oncolytic virus therapy. The…”
Get full text

Assessing the prediction accuracy of a cure model for censored survival data with long-term survivors: Application to breast cancer data by Asano, Junichi, Hirakawa, Akihiro

“…The Cox proportional hazards cure model is a survival model incorporating a cure rate with the assumption that the population contains both uncured and cured…”
Get full text

Clinical characteristics of COVID-19 patients with underlying rheumatic diseases in Japan: data from a multicenter observational study using the COVID-19 Global Rheumatology Alliance physician-reported registry by Kihara, Mari, Sugihara, Takahiko, Asano, Junichi, Sato, Midori, Kaneko, Hiroshi, Muraoka, Sei, Ohshima, Shiro, Nanki, Toshihiro

“…Introduction To describe clinical characteristics of patients in Japan with coronavirus disease 19 (COVID-19) and pre-existing rheumatic disease and examine…”
Get full text

Insights into the clinical development of regenerative medical products through a comparison of three cell-based products recently approved for limbal stem cell deficiency by Aketa, Naohiko, Kasai, Masaki, Noda, Shinichi, Asano, Junichi, Kunieda, Akiyoshi, Kawanishi, Shohei, Maruyama, Yoshiaki, Honda, Futaba

“…Three regenerative medical products for limbal stem cell deficiency (LSCD), a rare and intractable ocular surface disease, have recently been approved in…”
Get full text

Assessing the prediction accuracy of cure in the Cox proportional hazards cure model: an application to breast cancer data by Asano, Junichi, Hirakawa, Akihiro, Hamada, Chikuma

“…A cure rate model is a survival model incorporating the cure rate with the assumption that the population contains both uncured and cured individuals. It is a…”
Get full text

Exposure of Drugs for Hypertension, Diabetes, and Autoimmune Disease During Pregnancy and Perinatal Outcomes: An Investigation of the Regulator in Japan by Sato, Ryosuke, Ikuma, Mutsuhiro, Takagi, Kazunori, Yamagishi, Yoshiaki, Asano, Junichi, Matsunaga, Yusuke, Watanabe, Hiroshi

“…Assessment of perinatal effects of drug exposure during pregnancy after approval is an important issue for regulatory agencies. The study aimed to explore…”
Get full text

A practical approach to non-natural or N-unsubstituted α-arylglycine derivatives: Hf(OTf)4-doped Me3SiCl system-catalyzed aminomethylation of electron-rich arenes with a new type of N,O-acetal by Sakai, Norio, Asano, Junichi, Shimano, Yuta, Konakahara, Takeo

Get full text

A Power Control Method to Save Energy for Wayside Energy Storage Systems in dc-Electrified Railway System by KOBAYASHI, HIROYASU, ASANO, JUNICHI, SAITO, TATSUHITO, KONDO, KEIICHIRO

“…SUMMARY The introduction of wayside energy storage systems is effective for the recovery of regenerative brake energy in dc‐electrified railways. However,…”
Get full text

Facile Approach to Natural or Non‐Natural Amino Acid Derivatives: Me 3 SiCl‐Promoted Coupling Reaction of Organozinc Compounds with N,O‐Acetals by Sakai, Norio, Asano, Junichi, Kawada, Yuki, Konakahara, Takeo

“…Abstract We have developed a Me 3 SiCl‐promoted coupling reaction of aryl‐ and alkylzinc compounds, in‐situ generated either by transmetalation of the…”
Get full text

A practical approach to non-natural or N-unsubstituted α-arylglycine derivatives: Hf(OTf) 4-doped Me 3SiCl system-catalyzed aminomethylation of electron-rich arenes with a new type of N, O-acetal by Sakai, Norio, Asano, Junichi, Shimano, Yuta, Konakahara, Takeo

“…The authors have demonstrated the Hf(OTf) 4-doped Me 3SiCl system-catalyzed aminomethylation of electron-rich aromatic compounds, such as indoles and anilines,…”
Get full text

Short-latency somatosensory evoked potentials and auditory brainstem responses in children with brainstem lesions by Asano, J, Tomita, Y

Get more information

CT findings and prognoses of anoxic brain damage due to near-drowning in children by Asano, J, Ieshima, A, Kisa, T, Ohtani, K

“…We investigated the relationship between serial cranial CT findings and prognoses in 11 children after near-drowning. These patients were rescued after heart…”
Get more information

Child-Related Strain for Mothers in a Japanese Community by Hirokawa, Kumi, Asano, Junichi, Masuno, Mitsuo, Usui, Yoko, Yoshida, Izumi, Shimizu, Hiroyuki

“…The purpose of the study was to identify risk and protective factors for child-related strain among Japanese mothers. The present study focused not only on…”
Get full text

Chediak-Higashi syndrome with cerebellar cortical atrophy detected by MRI by Kondo, N, Shimozawa, N, Asano, J, Imamura, A, Orii, T

Get more information