Search Results - "Asahina, Kinji"

Induction of Cell Death in Pancreatic Tumors by Zinc and Its Fluorescence Chelator TSQ by Asahina, Kinji

“…Pancreatic ductal adenocarcinoma is a devastating cancer and is the fourth-leading cause of cancer death in the USA. Zinc is abundant in the pancreas, but its…”
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Hepatic stellate cell progenitor cells by Asahina, Kinji

“…Hepatic stellate cells (HSCs) are recognized as a major player in liver fibrogenesis. Upon liver injury, HSCs differentiate into myofibroblasts and participate…”
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Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial–mesenchymal transition in liver injury by Li, Yuchang, Wang, Jiaohong, Asahina, Kinji

“…In many organs, myofibroblasts play a major role in the scarring process in response to injury. In liver fibrogenesis, hepatic stellate cells (HSCs) are…”
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Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling by Zindel, Joel, Mittner, Jonas, Bayer, Julia, April-Monn, Simon L., Kohler, Andreas, Nusse, Ysbrand, Dosch, Michel, Büchi, Isabel, Sanchez-Taltavull, Daniel, Dawson, Heather, Gomez de Agüero, Mercedes, Asahina, Kinji, Kubes, Paul, Macpherson, Andrew J., Stroka, Deborah, Candinas, Daniel

“…Abdominal surgeries are lifesaving procedures but can be complicated by the formation of peritoneal adhesions, intra-abdominal scars that cause intestinal…”
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Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers by Lua, Ingrid, Li, Yuchang, Zagory, Jessica A, Wang, Kasper S, French, Samuel W, Sévigny, Jean, Asahina, Kinji

“…Graphical abstract…”
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Myofibroblastic Conversion and Regeneration of Mesothelial Cells in Peritoneal and Liver Fibrosis by Lua, Ingrid, Li, Yuchang, Pappoe, Lamioko S, Asahina, Kinji

“…Mesothelial cells (MCs) form a single epithelial layer and line the surface of body cavities and internal organs. Patients who undergo peritoneal dialysis…”
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Editorial: Mesenchymal and immune cell crosstalk in fibrotic diseases by Asahina, Kinji, Ilangumaran, Subburaj

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The Role of Mesothelial Cells in Liver Development, Injury, and Regeneration by Lua, Ingrid, Asahina, Kinji

“…Mesothelial cells (MCs) cover the surface of visceral organs and the parietal walls of cavities, and they synthesize lubricating fluids to create a slippery…”
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TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis by Inokuchi-Shimizu, Sayaka, Park, Eek Joong, Roh, Yoon Seok, Yang, Ling, Zhang, Bi, Song, Jingyi, Liang, Shuang, Pimienta, Michael, Taniguchi, Koji, Wu, Xuefeng, Asahina, Kinji, Lagakos, William, Mackey, Mason R, Akira, Shizuo, Ellisman, Mark H, Sears, Dorothy D, Olefsky, Jerrold M, Karin, Michael, Brenner, David A, Seki, Ekihiro

“…The MAP kinase kinase kinase TGFβ-activated kinase 1 (TAK1) is activated by TLRs, IL-1, TNF, and TGFβ and in turn activates IKK-NF-κB and JNK, which regulate…”
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TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia by Short, Celia, Zhong, Allen, Xu, Jiabo, Mahdi, Elaa, Glazier, Alison, Malkoff, Nicolas, Noriega, Nicolas, Yeo, Theresa, Asahina, Kinji, Wang, Kasper S

“…Biliary atresia (BA), a congenital cholestatic liver disease, commonly culminates in end-stage liver disease. We previously demonstrated in BA that Prominin-1…”
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Isolation of a unique hepatic stellate cell population expressing integrin α8 from embryonic mouse livers by Ogawa, Tomohiro, Li, Yuchang, Lua, Ingrid, Hartner, Andrea, Asahina, Kinji

“…Hepatic stellate cells (HSCs) play an important role in liver fibrogenesis. However, little is known about their phenotype and role in liver development. The…”
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Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis by Cheng, Jason H, She, Hongyun, Han, Yuan-Ping, Wang, Jiaohong, Xiong, Shigang, Asahina, Kinji, Tsukamoto, Hidekazu

“…Activation of hepatic stellate cells (HSC), a key event in liver fibrosis, is caused by diminished adipogenic transcription. This study investigated whether…”
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Effect of Poly(N-vinyl-pyrrolidone)-block-poly(d,l-lactide) as Coating Agent on the Opsonization, Phagocytosis, and Pharmacokinetics of Biodegradable Nanoparticles by Gaucher, Geneviève, Asahina, Kinji, Wang, Jiaohong, Leroux, Jean-Christophe

“…The effect of the coating polymer poly(N-vinyl-pyrrolidone) (PVP) on the protein adsorption, phagocytosis, and pharmacokinetics of poly(D,L-lactide)-based…”
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Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development by Asahina, Kinji, Tsai, Shirley Y., Li, Peng, Ishii, Mamoru, Maxson, Robert E., Sucov, Henry M., Tsukamoto, Hidekazu

“…The knowledge concerning fetal hepatic stellate cells (HSCs) is scarce, and their cell lineage and functions are largely unknown. The current study isolated…”
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Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog by Machida, Keigo, Tsukamoto, Hidekazu, Mkrtchyan, Hasmik, Duan, Lewei, Dynnyk, Alla, Liu, Helene Minyi, Asahina, Kinji, Govindarajan, Sugantha, Ray, Ratna, Ou, Jing-hsiung James, Seki, Ekihiro, Deshaies, Raymond, Miyake, Kensuke, Lai, Michael M.-C

“…Alcohol synergistically enhances the progression of liver disease and the risk for liver cancer caused by hepatitis C virus (HCV). However, the molecular…”
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Epigenetic cell fate regulation of hepatic stellate cells by Tsukamoto, Hidekazu, Zhu, Nian-Ling, Asahina, Kinji, Mann, Derek A., Mann, Jelena

“…Research in the past three decades has identified key mediators and signaling mechanisms responsible for myofibroblastic transdifferentiation (MTD) of hepatic…”
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Urea-based amino sugar agent clears murine liver and preserves protein fluorescence and lipophilic dyes by Hough, Michelle, Fenlon, Michael, Glazier, Alison, Short, Celia, Fernandez, Gerardo Esteban, Xu, Jiabo, Mahdi, Elaa, Asahina, Kinji, Wang, Kasper S

“…Five established clearing protocols were compared with a modified and simplified method to determine an optimal clearing reagent for three-dimensionally…”
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Near Completely Humanized Liver in Mice Shows Human-Type Metabolic Responses to Drugs by Tateno, Chise, Yoshizane, Yasumi, Saito, Naomi, Kataoka, Miho, Utoh, Rie, Yamasaki, Chihiro, Tachibana, Asato, Soeno, Yoshinori, Asahina, Kinji, Hino, Hiroshi, Asahara, Toshimasa, Yokoi, Tsuyoshi, Furukawa, Toshinori, Yoshizato, Katsutoshi

“…Human hepatocytes were transplanted into urokinase-type plasminogen activator-transgenic SCID mice (uPA/SCID mice), which are immunodeficient and undergo liver…”
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Phosphorylation of histone H2AX at M phase in human cells without DNA damage response by Ichijima, Yosuke, Sakasai, Ryo, Okita, Naoyuki, Asahina, Kinji, Mizutani, Shuki, Teraoka, Hirobumi

“…A variant of histone H2A, H2AX, is phosphorylated on Ser139 in response to DNA double-strand breaks (DSBs), and clusters of the phosphorylated form of H2AX…”
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Activation of hepatic stellate cell in Pten null liver injury model by He, Lina, Gubbins, James, Peng, Zhechu, Medina, Vivian, Fei, Fan, Asahina, Kinji, Wang, Jiaohong, Kahn, Michael, Rountree, Carl B, Stiles, Bangyan L

“…Hepatic fibrosis is a prominent pathological feature associated with chronic liver disease including non-alcoholic hepatosteatosis (NASH), and a precursor for…”
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