Search Results - "Asahina, Hajime"

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints by Koyama, Shohei, Akbay, Esra A., Li, Yvonne Y., Herter-Sprie, Grit S., Buczkowski, Kevin A., Richards, William G., Gandhi, Leena, Redig, Amanda J., Rodig, Scott J., Asahina, Hajime, Jones, Robert E., Kulkarni, Meghana M., Kuraguchi, Mari, Palakurthi, Sangeetha, Fecci, Peter E., Johnson, Bruce E., Janne, Pasi A., Engelman, Jeffrey A., Gangadharan, Sidharta P., Costa, Daniel B., Freeman, Gordon J., Bueno, Raphael, Hodi, F. Stephen, Dranoff, Glenn, Wong, Kwok-Kin, Hammerman, Peter S.

“…Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1): programmed death ligand 1 (PD-L1) immune checkpoint in lung…”
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First-line osimertinib in elderly patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer: a retrospective multicenter study (HOT2002) by Yamamoto, Gaku, Asahina, Hajime, Honjo, Osamu, Sumi, Toshiyuki, Nakamura, Atsushi, Ito, Kenichiro, Kikuchi, Hajime, Hommura, Fumihiro, Honda, Ryoichi, Yokoo, Keiki, Fujita, Yuka, Oizumi, Satoshi, Morita, Ryo, Ikezawa, Yasuyuki, Tanaka, Hisashi, Kimura, Nozomu, Sasaki, Takaaki, Sukoh, Noriaki, Takashina, Taichi, Harada, Toshiyuki, Dosaka-Akita, Hirotoshi, Isobe, Hiroshi

“…Osimertinib is a standard of care therapy for previously untreated epidermal growth factor receptor mutation-positive non-small cell lung cancer. However,…”
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Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS by Kitajima, Shunsuke, Asahina, Hajime, Chen, Ting, Guo, Sujuan, Quiceno, Laura Gutierrez, Cavanaugh, Jillian D., Merlino, Ashley A., Tange, Shoichiro, Terai, Hideki, Kim, Jong Wook, Wang, Xiaoen, Zhou, Shan, Xu, Man, Wang, Stephen, Zhu, Zehua, Thai, Tran C., Takahashi, Chiaki, Wang, Yujin, Neve, Richard, Stinson, Susanna, Tamayo, Pablo, Watanabe, Hideo, Kirschmeier, Paul T., Wong, Kwok-Kin, Barbie, David A.

“…Despite extensive efforts, oncogenic KRAS remains resistant to targeted therapy. Combined downstream RAL-TBK1 and MEK inhibition induces only transient lung…”
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Temporary Severe Neutropenia during Administration of Atezolizumab: A Novel Case Report by Kanno, Ryota, Saito, Yoshitaka, Takekuma, Yoh, Asahina, Hajime, Sugawara, Mitsuru

“…Abstract Here, we describe a case of temporary severe neutropenia after atezolizumab monotherapy and its treatment course. Atezolizumab monotherapy was…”
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Significantly Delayed Development of Polyarthritis with Active Tenosynovitis after Possible Temporary Neutropenic Immune-Related Adverse Events Caused by Atezolizumab Treatment: A Novel Case Report by Saito, Yoshitaka, Takekuma, Yoh, Asahina, Hajime, Hisada, Ryo, Sugawara, Mitsuru

“…Immune checkpoint inhibitors have drastically improved cancer treatment. However, they may induce immune-related adverse events (irAEs). Here, we report a case…”
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Factors related to diagnostic yield of transbronchial biopsy using endobronchial ultrasonography with a guide sheath in small peripheral pulmonary lesions by Yamada, Noriyuki, Yamazaki, Koichi, Kurimoto, Noriaki, Asahina, Hajime, Kikuchi, Eiki, Shinagawa, Naofumi, Oizumi, Satoshi, Nishimura, Masaharu

“…To evaluate factors predicting the diagnostic yield of transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS) in small…”
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Combined Survival Analysis of Prospective Clinical Trials of Gefitinib for Non–Small Cell Lung Cancer with EGFR Mutations by MORITA, Satoshi, OKAMOTO, Isamu, YOSHIDA, Kimihide, HIRASHIMA, Tomonori, YASUMOTO, Kosei, SUGIO, Kenji, MITSUDOMI, Tetsuya, FUKUOKA, Masahiro, NUKIWA, Toshihiro, KOBAYASHI, Kunihiko, YAMAZAKI, Koichi, ASAHINA, Hajime, INOUE, Akira, HAGIWARA, Koichi, SUNAGA, Noriaki, YANAGITANI, Noriko, HIDA, Toyoaki

“…Purpose: Somatic mutations of the epidermal growth factor receptor ( EGFR ) gene are associated with an increased response to gefitinib in patients with…”
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Risk of bleeding associated with transbronchial biopsy using flexible bronchoscopy in patients with echocardiographic or chest CT evidence of pulmonary hypertension by Takashima, Yuta, Shinagawa, Naofumi, Morinaga, Daisuke, Nakamura, Junichi, Furuta, Megumi, Shoji, Tetsuaki, Asahina, Hajime, Kikuchi, Eiki, Kikuchi, Junko, Sakakibara-Konishi, Jun, Tsujino, Ichizo, Konno, Satoshi

“…Abstract Background Endobronchial ultrasound (EBUS)-guided transbronchial biopsy (TBB) facilitates the diagnosis of various respiratory diseases. The safety of…”
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A Phase I, dose‐finding and pharmacokinetic study of olaparib (AZD2281) in Japanese patients with advanced solid tumors by Yamamoto, Noboru, Nokihara, Hiroshi, Yamada, Yasuhide, Goto, Yasushi, Tanioka, Maki, Shibata, Takashi, Yamada, Kazuhiko, Asahina, Hajime, Kawata, Toshio, Shi, Xiaojin, Tamura, Tomohide

“…Olaparib (AZD2281) is an orally active Poly(ADP‐ribose) polymerase (PARP) inhibitor with favorable antitumor activity in advanced ovarian and breast cancers…”
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Innovator and generic cisplatin formulations: Comparison of renal toxicity by Sekine, Ikuo, Kubota, Kaoru, Tamura, Yosuke, Asahina, Hajime, Yamada, Kazuhiko, Horinouchi, Hidehito, Nokihara, Hiroshi, Yamamoto, Noboru, Tamura, Tomohide

“…To compare the incidence and degree of renal toxicity associated with innovator and generic cisplatin formulations, increase in the serum creatinine (CRN)…”
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Real‐world data on the efficacy and safety of immune‐checkpoint inhibitors in elderly patients with non‐small cell lung cancer by Morinaga, Daisuke, Asahina, Hajime, Ito, Shotaro, Honjo, Osamu, Tanaka, Hisashi, Honda, Ryoichi, Yokouchi, Hiroshi, Nakamura, Keiichi, Takamura, Kei, Hommura, Fumihiro, Kawai, Yasutaka, Ito, Kenichiro, Sukoh, Noriaki, Yokoo, Keiki, Morita, Ryo, Harada, Toshiyuki, Takashina, Taichi, Goda, Tomohiro, Dosaka‐Akita, Hirotoshi, Isobe, Hiroshi

“…Purpose Immune‐checkpoint inhibitors (ICIs) are effective against advanced non‐small cell lung cancer (NSCLC). However, whether the efficacy and safety of ICI…”
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Transbronchial biopsy using endobronchial ultrasonography with a guide sheath and virtual bronchoscopic navigation by Asahina, Hajime, Yamazaki, Koichi, Onodera, Yuya, Kikuchi, Eiki, Shinagawa, Naofumi, Asano, Fumihiro, Nishimura, Masaharu

“…We evaluated the feasibility, safety, and efficacy of transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS) and virtual…”
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Successful Application of Edoxaban in the Treatment of Venous Thromboembolism Recurrence in a Patient with Non-small Cell Lung Cancer after Tumor Shrinkage by Shoji, Tetsuaki, Mizugaki, Hidenori, Ikezawa, Yasuyuki, Furuta, Megumi, Takashima, Yuta, Kikuchi, Hajime, Goudarzi, Houman, Asahina, Hajime, Kikuchi, Junko, Kikuchi, Eiki, Sakakibara-Konishi, Jun, Shinagawa, Naofumi, Tsujino, Ichizo, Nishimura, Masaharu

“…This report describes the case of a 66-year-old man with non-small cell lung cancer and venous thromboembolism (VTE). Unfractionated heparin (UFH) was…”
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Factors related to diagnostic sensitivity using an ultrathin bronchoscope under CT guidance by Shinagawa, Naofumi, Yamazaki, Koichi, Onodera, Yuya, Asahina, Hajime, Kikuchi, Eiki, Asano, Fumihiro, Miyasaka, Kazuo, Nishimura, Masaharu

“…We investigated factors related to the diagnostic sensitivity of CT-guided transbronchial biopsy (TBB) using an ultrathin bronchoscope and virtual bronchoscopy…”
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A phase 1 study of ramucirumab in Japanese patients with advanced solid tumors by Nokihara, Hiroshi, Yamamoto, Noboru, Yamada, Yasuhide, Honda, Kazunori, Asahina, Hajime, Tamura, Yosuke, Hozak, Rebecca R, Gao, Ling, Suzukawa, Kazumi, Enatsu, Sotaro, Tamura, Tomohide

“…Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. The aim of this phase 1…”
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Synchronous Oligometastasis and Oligoprogression as a Prognostic Marker in Patients With Extensive-Stage SCLC Treated With a Combination of Immune-Checkpoint Inhibitor and Chemotherapy (HOT2301) by Hashimoto, Kana, Morinaga, Daisuke, Asahina, Hajime, Ishidoya, Mina, Kikuchi, Hajime, Yokouchi, Hiroshi, Harada, Toshiyuki, Honjo, Osamu, Shigaki, Ryota, Takashina, Taichi, Fujita, Yuka, Takahashi, Mamoru, Kawai, Yasutaka, Kida, Ryotaro, Ito, Kenichiro, Sukoh, Noriaki, Takahashi, Ayumu, Hommura, Fumihiro, Ohhara, Yoshihito, Furuta, Megumi, Konno, Satoshi, Hosomi, Yukio, Oizumi, Satoshi

“…Oligometastasis and oligoprogression (OP) has not been adequately defined in extensive-stage SCLC (ES-SCLC) and may be a good indication for adding local…”
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Necrolytic migratory erythema-like eruptions induced by zinc deficiency during osimertinib treatment of EGFR-mutant non-small cell lung cancer: A case report by Yamamoto, Gaku, Asahina, Hajime, Iwata, Hiroaki, Takakuwa, Emi, Ito, Shotaro, Kunisaki, Mamoru, Takashima, Yuta, Kikuchi, Junko, Kikuchi, Eiki, Sakakibara-Konishi, Jun, Shinagawa, Naofumi, Konno, Satoshi

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Retrospective Analysis of Third-Line and Fourth-Line Chemotherapy for Advanced Non–Small-Cell Lung Cancer by Asahina, Hajime, Sekine, Ikuo, Horinouchi, Hidehito, Nokihara, Hiroshi, Yamamoto, Noboru, Kubota, Kaoru, Tamura, Tomohide

“…Micro-Abstract The efficacy of third-line chemotherapy for advanced non–small-cell lung cancer (NSCLC) remains unknown. The clinical outcome of 599 patients…”
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Endobronchial Ultrasonography With a Guide Sheath in the Diagnosis of Benign Peripheral Diseases by Shinagawa, Naofumi, MD, PhD, Nakano, Kosuke, MD, Asahina, Hajime, MD, PhD, Kikuchi, Eiki, MD, PhD, Ito, Tomoo, MD, PhD, Matsuno, Yoshihiro, MD, PhD, Oizumi, Satoshi, MD, PhD, Nasuhara, Yasuyuki, MD, PhD, Nishimura, Masaharu, MD, PhD

“…Background For appropriate treatment, such as the selection of antibiotics or initiation of steroid therapy, correctly diagnosing benign pulmonary diseases…”
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A case of radio-insensitive SMARCA4-deficient thoracic undifferentiated carcinoma with severe right heart failure by Ito, Shotaro, Asahina, Hajime, Yamaguchi, Naoko, Tomaru, Utano, Hasegawa, Tadashi, Hatanaka, Yutaka, Hatanaka, Kanako C., Taguchi, Hiroshi, Harada, Taisuke, Ohira, Hiroshi, Ikeda, Daisuke, Mizugaki, Hidenori, Kikuchi, Eiki, Kikuchi, Junko, Sakakibara-Konishi, Jun, Shinagawa, Naofumi, Konno, Satoshi

“…SMARCA4-deficient thoracic sarcomatoid tumors were characterized by inactivating mutations of SMARCA4 and often found in the chest of young and middle-aged…”
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