Search Results - "Asad, Mohammad Fahad B."
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Impact of XPO1 mutations on survival outcomes in metastatic non-small cell lung cancer (NSCLC)
Published in Lung cancer (Amsterdam, Netherlands) (01-10-2021)“…•In cancer, hyperactive XPO1 promotes the export of important tumor suppressors.•Among 18,218 NSCLC tumors, 26 harbored XPO1 mutations and 24 had…”
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A Rare Case of CD1a +/CD207 + and S100 - Langerhans Cell Histiocytosis with Multi-System Risk Organ Involvement in Adult
Published in Blood (02-11-2023)“…Introduction: Langerhans Cell Histiocytosis (LCH) is a rare neoplastic disorder of myeloid dendritic cell precursors, leading to a spectrum of organ…”
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Heterozygous CTC1 Variants in Acquired Bone Marrow Failure
Published in Blood (29-11-2018)“…Germ line (GL) alterations of telomerase machinery genes may lead to inherited telomeropathies, but recent analysis of large control populations revealed that…”
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Prognostic impact of XPO1 mutations in metastatic non-small cell lung cancer (NSCLC)
Published in Journal of clinical oncology (20-05-2021)“…Abstract only e20533 Background: Nuclear protein transport is essential in guiding the organized traffic of important proteins and RNAs between the nucleus and…”
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Extent and Clinical Implications of Subclonal Diversity in Paroxysmal Nocturnal Hemoglobinuria
Published in Blood (08-12-2017)“…Paroxysmal Nocturnal hemoglobinuria (PNH) has been traditionally considered a monogenic disease due to somatic mutations in PIGA gene. While selective immune…”
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Genotype-Resultant Morphology of Myelodysplastic Syndromes (MDS)
Published in Blood (29-11-2018)“…Morphology has dominated the diagnosis and classification of MDS for decades. With the advent of NGS, morphology is used as a gold standard to assess…”
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How Somatic Mutations Carve Morphologic Imprint in MDS?
Published in Blood (08-12-2017)“…Next generation sequencing (NGS) investigations have identified individual mutations that have been useful in differential diagnoses and as biomarkers of…”
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Biallelic TET2 Inactivation in Myeloid Neoplasia: From Clonal Hierarchy to Clinical Phenotypes
Published in Blood (29-11-2018)“…Genomic data has led to the identification of bio-markers of morphological features and disease sub-entities in myeloid neoplasia (MN). Somatic TET2 mutations…”
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Invariant Patterns of Clonal Succession Determines Specific Phenotypic and Clinical Features of Myelodysplastic Syndromes (MDS)
Published in Blood (29-11-2018)“…MDS arises through stepwise acquisitions of multiple mutations. Mutation configuration (bi-allelic vs. mono-allelic), specific distributions (hot spot), timing…”
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Non-Random Interactions between Founder and Subclonal Mutations Shape the Clinical and Morphological Features of MDS
Published in Blood (08-12-2017)“…The clinical heterogeneity of MDS results from the combinatorial diversity of seemingly random, and thus individually unique, clone mutation hierarchies…”
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Model Heterogeneity in Predicting Outcomes of Patients with Myelodysplastic Syndromes (MDS)
Published in Blood (08-12-2017)“…Background The outcome of MDS patients (pts) is heterogeneous, with some pts living for years, while others die within a few months of diagnosis. Several…”
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BCOR Mutations in Myelodysplastic Syndromes (MDS): Mutation Characteristics Impact Clinical Outcomes
Published in Blood (08-12-2017)“…Introduction Several recurrent somatic mutations have been identified in myelodysplastic syndromes (MDS) and these mutations play an important role in disease…”
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