CD56, CD57, HBME1, CK19, Galectin-3 and p63 immunohistochemical stains in differentiating diagnosis of thyroid benign/malign lesions and NIFTP

CD56, CD57, HBME1, CK19, Galectin-3 and p63 immunohistochemical stains in differentiating diagnosis of thyroid benign/malign lesions and NIFTP

Detection of thyroid carcinoma has been steadily increased in the past few decades. After the recognition of NIFTP, also gain importance to differentiate benign tumors (follicular adenoma) from follicular patterned variants of papillary thyroid carcinoma (invasive and infiltrative follicular variant...

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Bibliographic Details
Published in:Polish journal of pathology Vol. 70; no. 4; pp. 286 - 294
Main Authors: Tastekin, Ebru, Keskin, Elif, Can, Nuray, Canberk, Sule, Mut, Ayse, Erdogan, Ezgi, Asa, Nurtac, Güldiken, Sibel, Sezer, Atakan, Azatcam, Meltem
Format: Journal Article
Language:English
Published: Poland Termedia Publishing House 01-01-2019
Subjects:
Adenocarcinoma, Follicular - diagnosis
Biomarkers, Tumor - genetics
cd56
CD56 Antigen
cd57
CD57 Antigens
Cell adhesion & migration
ck19
Cytokinins
differential diagnosis
Galectin 3
hbme1
Humans
Hyperplasia
Hypotheses
Immunohistochemistry
Membrane Proteins
p63
Patients
Stains & staining
Thyroid cancer
Thyroid Cancer, Papillary - diagnosis
Thyroid Gland - pathology
thyroid lesions
Tumors
differential diagnosis
thyroid lesions
HBME1
Galectin-3
CD57
p63
CD56
CK19
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Summary:Detection of thyroid carcinoma has been steadily increased in the past few decades. After the recognition of NIFTP, also gain importance to differentiate benign tumors (follicular adenoma) from follicular patterned variants of papillary thyroid carcinoma (invasive and infiltrative follicular variant papillary thyroid carcinoma), and low-risk lesions of thyroid (NIFTP). Follicular patterned proliferations of thyroid still persists as a battle for pathologists. In this study, we aimed to analyze the most commonly used immunohistochemical stains "HBME1, CK19, Galectin-3", adding the new ones "CD56, CD57, and p63". Study groups were; nodular hyperplasia, follicular adenoma, NIFTP, infiltrative follicular variant PTC, classical variant PTC (CVPTC) and follicular carcinoma. Each group consisted of twenty cases. The sections were stained with CD56, CD57, p63, CK19, HBME1 (Mesotel cell), Galectin-3 antibody. Although the expression of CD56 was high in benign follicular lesions, FC could not be excluded in this group. CD57 was high in malignant follicular group and NIFTP. Interestingly, p63 was found highly expressed in FVPTC, which might be promising to predict invasiveness in follicular group of lesions. CK19, Galectin-3 and HBME1 were found quietly prominent in CVPTC in concordance with the previous reports.
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ISSN:1233-9687
2084-9869
DOI:10.5114/PJP.2019.93131