Search Results - "Arzumanov, Andrey A"

Cell-Penetrating Peptide Conjugates of Steric Blocking Oligonucleotides as Therapeutics for Neuromuscular Diseases from a Historical Perspective to Current Prospects of Treatment by Gait, Michael J, Arzumanov, Andrey A, McClorey, Graham, Godfrey, Caroline, Betts, Corinne, Hammond, Suzan, Wood, Matthew J A

“…The review starts with a historical perspective of the achievements of the Gait group in synthesis of oligonucleotides (ONs) and their peptide conjugates…”
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Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment by Betts, Corinne, Saleh, Amer F, Arzumanov, Andrey A, Hammond, Suzan M, Godfrey, Caroline, Coursindel, Thibault, Gait, Michael J, Wood, Matthew JA

“…Antisense oligonucleotides (AOs) are currently the most promising therapeutic intervention for Duchenne muscular dystrophy (DMD). AOs modulate dystrophin…”
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Parallel synthesis and splicing redirection activity of cell-penetrating peptide conjugate libraries of a PNA cargo by Deuss, Peter J, Arzumanov, Andrey A, Williams, Donna L, Gait, Michael J

“…A novel method for the parallel synthesis of peptide-biocargo conjugates was developed that utilizes affinity purification for fast isolation of the conjugates…”
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Systematic screening of LNA/2′- O-methyl chimeric derivatives of a TAR RNA aptamer by Di Primo, Carmelo, Rudloff, Ivo, Reigadas, Sandrine, Arzumanov, Andrey A., Gait, Michael J., Toulmé, Jean-Jacques

“…We synthesized and evaluated by surface plasmon resonance 64 LNA/2′- O-methyl sequences corresponding to all possible combinations of such residues in a…”
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PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation by Ezzat, Kariem, EL Andaloussi, Samir, Zaghloul, Eman M., Lehto, Taavi, Lindberg, Staffan, Moreno, Pedro M. D., Viola, Joana R., Magdy, Tarek, Abdo, Rania, Guterstam, Peter, Sillard, Rannar, Hammond, Suzan M., Wood, Matthew J. A., Arzumanov, Andrey A., Gait, Michael J., Smith, C. I. Edvard, Hällbrink, Mattias, Langel, Ülo

“…Numerous human genetic diseases are caused by mutations that give rise to aberrant alternative splicing. Recently, several of these debilitating disorders have…”
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Cell penetrating peptide conjugates of steric block oligonucleotides by Lebleu, Bernard, Moulton, Hong M., Abes, Rachida, Ivanova, Gabriela D., Abes, Said, Stein, David A., Iversen, Patrick L., Arzumanov, Andrey A., Gait, Michael J.

“…Charge neutral steric block oligonucleotide analogues, such as peptide nucleic acids (PNA) or phosphorodiamidate morpholino oligomers (PMO), have promising…”
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RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA by Turner, John J., Jones, Simon, Fabani, Martin M., Ivanova, Gabriela, Arzumanov, Andrey A., Gait, Michael J.

“…Towards the development of oligonucleotide analogues and siRNA as drugs, one potential alternative to the use of liposomal transfection agents is the covalent…”
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Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells by Turner, John J., Ivanova, Gabriela D., Verbeure, Birgit, Williams, Donna, Arzumanov, Andrey A., Abes, Saïd, Lebleu, Bernard, Gait, Michael J.

“…The trans-activation response (TAR) RNA stem–loop that occurs at the 5′ end of HIV RNA transcripts is an important antiviral target and is the site of…”
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Parallel synthesis of cell-penetrating peptide conjugates of PMO toward exon skipping enhancement in Duchenne muscular dystrophy by O'Donovan, Liz, Okamoto, Itaru, Arzumanov, Andrey A, Williams, Donna L, Deuss, Peter, Gait, Michael J

“…We describe two new methods of parallel chemical synthesis of libraries of peptide conjugates of phosphorodiamidate morpholino oligonucleotide (PMO) cargoes on…”
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Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides by Turner, John J., Arzumanov, Andrey A., Gait, Michael J.

“…Oligonucleotides composed of 2′-O-methyl and locked nucleic acid residues complementary to HIV-1 trans-activation responsive element TAR block Tat-dependent…”
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A Peptide-Based Dendrimer That Enhances the Splice-Redirecting Activity of PNA Conjugates in Cells by Hassane, Fatouma Said, Ivanova, Gabriela D, Bolewska-Pedyczak, Eleonora, Abes, Rachida, Arzumanov, Andrey A, Gait, Michael J, Lebleu, Bernard, Gariépy, Jean

“…The full therapeutic potential of oligonucleotide (ON)-based agents has been hampered by cellular delivery challenges. Cell-penetrating peptides (CPP)…”
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Peptide nanoparticle delivery of charge-neutral splice-switching morpholino oligonucleotides by Järver, Peter, Zaghloul, Eman M, Arzumanov, Andrey A, Saleh, Amer F, McClorey, Graham, Hammond, Suzan M, Hällbrink, Mattias, Langel, Ülo, Smith, C I Edvard, Wood, Matthew J A, Gait, Michael J, El Andaloussi, Samir

“…Oligonucleotide analogs have provided novel therapeutics targeting various disorders. However, their poor cellular uptake remains a major obstacle for their…”
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Peptide-based delivery of steric-block PNA oligonucleotides by Abes, Saïd, Ivanova, Gabriela D, Abes, Rachida, Arzumanov, Andrey A, Williams, Donna, Owen, David, Lebleu, Bernard, Gait, Michael J

“…Several strategies based on synthetic oligonucleotides (ON) have been proposed to control gene expression. As for most biomolecules, however, delivery has…”
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Targeting the HIV-1 RNA leader sequence with synthetic oligonucleotides and siRNA: Chemistry and cell delivery by Turner, John J., Fabani, Martin, Arzumanov, Andrey A., Ivanova, Gabriela, Gait, Michael J.

“…New candidates for development as potential drugs or virucides against HIV-1 infection and AIDS continue to be needed. The HIV-1 RNA leader sequence has many…”
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Synthesis of Peptide−Oligonucleotide Conjugates with Single and Multiple Peptides Attached to 2‘-Aldehydes through Thiazolidine, Oxime, and Hydrazine Linkages by Zatsepin, Timofei S, Stetsenko, Dmitry A, Arzumanov, Andrey A, Romanova, Elena A, Gait, Michael J, Oretskaya, Tatiana S

“…2‘-Deoxyoligonucleotides and 2‘-O-methyloligoribonucleotides carrying one or more 2‘-aldehyde groups were synthesized and coupled to peptides containing an…”
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Enhanced splice correction by 3', 5'-serinol and 2'-(ω-O-methylserinol) guarded OMe-RNA/DNA mixmers in cells by Kotikam, Venubabu, Arzumanov, Andrey A, Gait, Michael J, Kumar, Vaijayanti A

“…Development of artificial nucleic acids for therapeutic applications warrants that the oligomers be endowed with high specificity, enzymatic stability and with…”
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Steric inhibition of human immunodeficiency virus type‐1 Tat‐dependent trans‐activation in vitro and in cells by oligonucleotides containing 2′‐O‐methyl G‐clamp ribonucleoside analogues by Holmes, Stephen C., Arzumanov, Andrey A., Gait, Michael J.

“…We report the synthesis of a novel 2′‐O‐methyl (OMe) riboside phosphoramidite derivative of the G‐clamp tricyclic base and incorporation into a series of small…”
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Overview of alternative oligonucleotide chemistries for exon skipping by Saleh, Amer F, Arzumanov, Andrey A, Gait, Michael J

“…The chemistry of the oligonucleotide backbone is crucial to obtaining high activity in vivo in exon skipping applications. Apart from the ability to bind…”
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A bi-functional siRNA construct induces RNA interference and also primes PCR amplification for its own quantification by Jiang, Ming, Arzumanov, Andrey A., Gait, Michael J., Milner, Jo

“…RNA interference (RNAi) is a process of post-transcriptional gene silencing initiated by double-stranded RNAs, including short interfering RNA (siRNA)…”
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Anti-HIV Activity of Steric Block Oligonucleotides by IVANOVA, GABRIELA, ARZUMANOV, ANDREY A., TURNER, JOHN J., REIGADAS, SANDRINE, TOULMÉ, JEAN-JACQUES, BROWN, DOUGLAS E., LEVER, ANDREW M.L., GAIT, MICHAEL J.

“…:  The unabated increase in spread of HIV infection worldwide has redoubled efforts to discover novel antiviral and virucidal agents that might be starting…”
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