Search Results - "Arzumanov, A. A."

Cell-Penetrating Peptide Conjugates of Steric Blocking Oligonucleotides as Therapeutics for Neuromuscular Diseases from a Historical Perspective to Current Prospects of Treatment by Gait, Michael J, Arzumanov, Andrey A, McClorey, Graham, Godfrey, Caroline, Betts, Corinne, Hammond, Suzan, Wood, Matthew J A

“…The review starts with a historical perspective of the achievements of the Gait group in synthesis of oligonucleotides (ONs) and their peptide conjugates…”
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Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment by Betts, Corinne, Saleh, Amer F, Arzumanov, Andrey A, Hammond, Suzan M, Godfrey, Caroline, Coursindel, Thibault, Gait, Michael J, Wood, Matthew JA

“…Antisense oligonucleotides (AOs) are currently the most promising therapeutic intervention for Duchenne muscular dystrophy (DMD). AOs modulate dystrophin…”
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PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation by Ezzat, Kariem, EL Andaloussi, Samir, Zaghloul, Eman M., Lehto, Taavi, Lindberg, Staffan, Moreno, Pedro M. D., Viola, Joana R., Magdy, Tarek, Abdo, Rania, Guterstam, Peter, Sillard, Rannar, Hammond, Suzan M., Wood, Matthew J. A., Arzumanov, Andrey A., Gait, Michael J., Smith, C. I. Edvard, Hällbrink, Mattias, Langel, Ülo

“…Numerous human genetic diseases are caused by mutations that give rise to aberrant alternative splicing. Recently, several of these debilitating disorders have…”
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Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells by Turner, John J., Ivanova, Gabriela D., Verbeure, Birgit, Williams, Donna, Arzumanov, Andrey A., Abes, Saïd, Lebleu, Bernard, Gait, Michael J.

“…The trans-activation response (TAR) RNA stem–loop that occurs at the 5′ end of HIV RNA transcripts is an important antiviral target and is the site of…”
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Parallel synthesis and splicing redirection activity of cell-penetrating peptide conjugate libraries of a PNA cargo by Deuss, Peter J, Arzumanov, Andrey A, Williams, Donna L, Gait, Michael J

“…A novel method for the parallel synthesis of peptide-biocargo conjugates was developed that utilizes affinity purification for fast isolation of the conjugates…”
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Synthesis, cellular uptake and HIV-1 Tat-dependent trans-activation inhibition activity of oligonucleotide analogues disulphide-conjugated to cell-penetrating peptides by Turner, John J., Arzumanov, Andrey A., Gait, Michael J.

“…Oligonucleotides composed of 2′-O-methyl and locked nucleic acid residues complementary to HIV-1 trans-activation responsive element TAR block Tat-dependent…”
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Cell-penetrating-peptide-based delivery of oligonucleotides: an overview by Abes, R, Arzumanov, A A, Moulton, H M, Abes, S, Ivanova, G D, Iversen, P L, Gait, M J, Lebleu, B

“…Cationic CPPs (cell-penetrating peptides) have been used largely for intracellular delivery of low-molecular-mass drugs, biomolecules and particles. Most…”
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Systematic screening of LNA/2′- O-methyl chimeric derivatives of a TAR RNA aptamer by Di Primo, Carmelo, Rudloff, Ivo, Reigadas, Sandrine, Arzumanov, Andrey A., Gait, Michael J., Toulmé, Jean-Jacques

“…We synthesized and evaluated by surface plasmon resonance 64 LNA/2′- O-methyl sequences corresponding to all possible combinations of such residues in a…”
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Using 320-slice perfusion computed tomography in visuali zation of prostate cancer by Sosnowski, N. V., Rozengauz, E. V., Shkolnik, M. I., Nesterov, D. V., Arzumanov, A. A.

“…Visualization of prostate cancer remains an actual problem in urology and oncology. Purpose of the study – evaluation of prostate cancer visualization using…”
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On the Protection of Intangible Heritage of Russian Folk Oral Music in the Context of Intercultural Communication (Hulunbuir, Inner Mongolia) by Ping, L., Yuyshin, M. A., Arzumanov, I. A.

“…The article discusses the issues of preserving the genre of Russian folk oral musical creativity in the village of the Argun and the city of Hulunbuir, Inner…”
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Arginine-rich cell penetrating peptides: Design, structure-activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides by Abes, R., Arzumanov, A., Moulton, H., Abes, S., Ivanova, G., Gait, M. J., Iversen, P., Lebleu, B.

“…Rerouting the splicing machinery with steric‐block oligonucleotides (ON) might lead to new therapeutic strategies in the treatment of diseases such as…”
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Peptide nanoparticle delivery of charge-neutral splice-switching morpholino oligonucleotides by Järver, Peter, Zaghloul, Eman M, Arzumanov, Andrey A, Saleh, Amer F, McClorey, Graham, Hammond, Suzan M, Hällbrink, Mattias, Langel, Ülo, Smith, C I Edvard, Wood, Matthew J A, Gait, Michael J, El Andaloussi, Samir

“…Oligonucleotide analogs have provided novel therapeutics targeting various disorders. However, their poor cellular uptake remains a major obstacle for their…”
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Synthesis of Peptide−Oligonucleotide Conjugates with Single and Multiple Peptides Attached to 2‘-Aldehydes through Thiazolidine, Oxime, and Hydrazine Linkages by Zatsepin, Timofei S, Stetsenko, Dmitry A, Arzumanov, Andrey A, Romanova, Elena A, Gait, Michael J, Oretskaya, Tatiana S

“…2‘-Deoxyoligonucleotides and 2‘-O-methyloligoribonucleotides carrying one or more 2‘-aldehyde groups were synthesized and coupled to peptides containing an…”
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Inhibition of HIV-1 Tat-Dependent Trans Activation by Steric Block Chimeric 2‘-O-Methyl/LNA Oligoribonucleotides by Arzumanov, Andrey, Walsh, Andrew P, Rajwanshi, Vivek K, Kumar, Ravindra, Wengel, Jesper, Gait, Michael J

“…The HIV-1 trans-activation responsive element (TAR) RNA 59-residue stem−loop interacts with the HIV trans-activator protein Tat and other cellular factors to…”
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Steric inhibition of human immunodeficiency virus type‐1 Tat‐dependent trans‐activation in vitro and in cells by oligonucleotides containing 2′‐O‐methyl G‐clamp ribonucleoside analogues by Holmes, Stephen C., Arzumanov, Andrey A., Gait, Michael J.

“…We report the synthesis of a novel 2′‐O‐methyl (OMe) riboside phosphoramidite derivative of the G‐clamp tricyclic base and incorporation into a series of small…”
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A bi-functional siRNA construct induces RNA interference and also primes PCR amplification for its own quantification by Jiang, Ming, Arzumanov, Andrey A., Gait, Michael J., Milner, Jo

“…RNA interference (RNAi) is a process of post-transcriptional gene silencing initiated by double-stranded RNAs, including short interfering RNA (siRNA)…”
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Cell penetrating peptide conjugates of steric block oligonucleotides by Lebleu, Bernard, Moulton, Hong M., Abes, Rachida, Ivanova, Gabriela D., Abes, Said, Stein, David A., Iversen, Patrick L., Arzumanov, Andrey A., Gait, Michael J.

“…Charge neutral steric block oligonucleotide analogues, such as peptide nucleic acids (PNA) or phosphorodiamidate morpholino oligomers (PMO), have promising…”
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RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA by Turner, John J., Jones, Simon, Fabani, Martin M., Ivanova, Gabriela, Arzumanov, Andrey A., Gait, Michael J.

“…Towards the development of oligonucleotide analogues and siRNA as drugs, one potential alternative to the use of liposomal transfection agents is the covalent…”
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Terminal deoxynucleotidyl transferase catalyzes the reaction of DNA phosphorylation by Arzumanov, A A, Victorova, L S, Jasko, M V, Yesipov, D S, Krayevsky, A A

“…The reaction of phosphorylation and phosphonylation of an oligodeoxynucleotide 3'-terminal hydroxyl (oligodeoxynucleotidyl kinase activity) catalyzed by calf…”
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Parallel synthesis of cell-penetrating peptide conjugates of PMO toward exon skipping enhancement in Duchenne muscular dystrophy by O'Donovan, Liz, Okamoto, Itaru, Arzumanov, Andrey A, Williams, Donna L, Deuss, Peter, Gait, Michael J

“…We describe two new methods of parallel chemical synthesis of libraries of peptide conjugates of phosphorodiamidate morpholino oligonucleotide (PMO) cargoes on…”
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