Search Results - "Arzneimittel-Forschung"

Bioequivalence of two lansoprazole delayed release capsules 30 mg in healthy male volunteers under fasting, fed and fasting-applesauce conditions: a partial replicate crossover study design to estimate the pharmacokinetics of highly variable drugs by Thota, S, Khan, S M, Tippabhotla, S K, Battula, R, Gadiko, C, Vobalaboina, V

“…An open-label, 2-treatment, 3-sequence, 3-period, single-dose, partial replicate crossover studies under fasting (n=48), fed (n=60) and fasting-applesauce…”
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The Preventive Oral Supplementation of a Selenium Nanoparticle-enriched Probiotic Increases the Immune Response and Lifespan of 4T1 Breast Cancer Bearing Mice by YAZDI, M. H, MAHDAVI, M, KHERADMAND, E, SHAHVERDI, A. R

“…The immunomodulatory effects of lactic acid bacteria have been demonstrated previously. In this study, a Lactobacillus plantarum strain was selected and…”
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Interaction of CJY, an isoflavone, with ATPase of P-glycoprotein in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells by Cen, J, Liu, L, He, L, Ji, B-S

“…The previous study reported CJY, an isoflavone, can reverse P-glycoprotein (P-gp)-mediated multidrug-resistance (MDR) in doxorubicin-resistant human…”
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Intrinsic and acquired drug resistance in malignant tumors. The main reason for therapeutic failure by Lippert, Theodor H, Ruoff, Hans-Jörg, Volm, Manfred

“…Drug resistance is the major reason for failure in cancer chemotherapy. Resistance may be either pre-existent (intrinsic resistance), or induced by drugs…”
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Intrinsic and Acquired Drug Resistance in Malignant Tumors by LIPPERT, Theodor H, RUOFF, Hans-Jörg, VOLM, Manfred

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Ginkgo biloba Special Extract in Dementia with Neuropsychiatric Features : A randomised, placebo-controlled, double-blind clinical trial by NAPRYEYENKO, Oleksandr, BORZENKO, Irina

“…In previous trials of the Ginkgo biloba special extract EGb 761 improvements in cognitive functioning and behavioural symptoms were found in patients with…”
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Development of a Subcutaneous Formulation for Trastuzumab: Nonclinical and Clinical Bridging Approach to the Approved Intravenous Dosing Regimen by BITTNER, B, RICHTER, W. F, HOURCADE-POTELLERET, F, MCLNTYRE, C, HERTING, F, ZEPEDA, M. L, SCHMIDT, J

“…A subcutaneous (SC) formulation has been developed for the humanized monoclonal antibody (mAb) trastuzumab as an alternative to established intravenous (IV)…”
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Pharmacokinetics and Potential Advantages of a New Oral Solution of Levothyroxine vs. other Available Dosage Forms by YUE, C. S, SCARSI, C, DUCHARME, M. P

“…To better understand the pharmacokinetics and potential advantages of a levothyroxine oral solution vs. tablets and soft gel capsules.4 randomized,…”
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Anti-nociceptive and Anti-inflammatory Effects of Cyanocobalamin (Vitamin B12) Against Acute and Chronic Pain and Inflammation in Mice by HOSSEINZADEH, H, MOALLEM, S. A, MOSHIRI, M, SARNAVAZI, M. S, ETEMAD, L

“…In this study, the anti-nociceptive and anti-inflammatory effects of cyanocobalamin (Vit B12) against acute and chronic pain and inflammation were evaluated in…”
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Paracetamol (acetaminophen) - a popular and widely used nonopioid analgesic by Klotz, U

“…For several decades paracetamol has proven its clinical efficacy and safety in the treatment of various acute and chronic pain states. Whereas its…”
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Design, Synthesis and Antihistaminic (H1)Activity of Some Condensed 2-(Substituted)arylaminoethyl-pyrimidin-4(3H)-ones by Shishoo, Chamanlal, Shirsath, Vikas, Rathod, Ishwarsinh, Patil, Milind, Bhargava, Samir

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Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents : A single-blind clinical investigation by CICERO, Arrigo F. G, ROVATI, Lucio C, SETNIKAR, Ivo

“…Berberine (BERB) and a combination (COMB) of berberine (CAS 2086-83-1) with policosanol (CAS 557-61-9), red yeast extract (containing monacolin, CAS 557-61-9),…”
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The efficacy and safety of current intravenous iron preparations for the management of iron-deficiency anaemia: a review by Qunibi, Wajeh Y

“…Iron-deficiency anaemia (IDA) is a major health problem worldwide, but responds well to iron supplementation. New approaches are leading to more effective…”
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The new generation of intravenous iron: chemistry, pharmacology, and toxicology of ferric carboxymaltose by Funk, Felix, Ryle, Peter, Canclini, Camillo, Neiser, Susann, Geisser, Peter

“…An ideal preparation for intravenous iron replacement therapy should balance effectiveness and safety. Compounds that release iron rapidly tend to cause…”
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Assessment of the extent of oxidative stress induced by intravenous ferumoxytol, ferric carboxymaltose, iron sucrose and iron dextran in a nonclinical model by TOBLLI, Jorge E, CAO, Gabriel, OLIVERI, Leda, ANGEROSA, Margarita

“…Intravenous (i.v.) iron is associated with a risk of oxidative stress. The effects of ferumoxytol, a recently approved i.v. iron preparation, were compared…”
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Male Reproductive Toxicity and Toxicokinetics of Triptolide in Rats by Ni, Bin, Jiang, Zhenzhou, Huang, Xin, Xu, Fengguo, Zhang, Rui, Zhang, Zunjian, Tian, Yuan, Wang, Tao, Zhu, Tian, Liu, Jing, Zhang, Luyong

“…As the unique quality control standard of Tabellae Glucosidorum Tripterygii Totorum, triptolide (CAS 38748-32-2) has a narrow therapeutic window. A significant…”
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Protective Effect of Puerarin on β-Amyloid-Induced Neurotoxicity in Rat Hippocampal Neurons by LIN, F, XIE, B, CAI, F, WU, G

“…Puerarin (CAS Number 3681-99-0), a major isoflavone glycoside purified from Pueraria lobata, was reported to possess antioxidative and estrogen-like biological…”
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Dapson in Heterocyclic Chemistry Part VI: Synthesis and Molecular Docking of Some Novel Sulfonebiscompounds of Expected Anticancer Activity by CHORAB, M. M, AL-SAID, M. S, NISSAN, Y. M

“…To discover new bioactive lead compounds for medicinal purposes, herein, sulfone biscompounds bearing dihydrothiazoles (3-9, 14, 15), acrylamide (11),…”
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Antioxidative and Lipid Lowering Effects of 7,8-Dihydroxy-3-(4-methylphenyl) Coumarin in Hyperlipidemic Rats by YUCE, Basak, DANIS, Ozkan, OGAN, Ayse, SENER, Goksel, BULUT, Mustafa, YARAT, Aysen

“…In this study, 7,8-dihydroxy-3-(4-methylphenyl) coumarin (DHMPC), a new coumarin derivative, was tested for the first time to determine whether it had any…”
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Synthesis and anticonvulsant activity of new kojic acid derivatives by AYTEMIR, Mutlu Dilsiz, SEPTIOGLU, Ebubekir, CALIS, Ünsal

“…A series of new 3-hydroxy-6-hydroxymethyl-2-substituted 4H-pyran-4-one derivatives were synthesized as potential anticonvulsant compounds. Mannich compounds…”
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