Search Results - "Arzberger, Thomas"

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease by Banzhaf-Strathmann, Julia, Benito, Eva, May, Stephanie, Arzberger, Thomas, Tahirovic, Sabina, Kretzschmar, Hans, Fischer, André, Edbauer, Dieter

“…Sporadic Alzheimer's disease (AD) is the most prevalent form of dementia, but no clear disease‐initiating mechanism is known. Aβ deposits and neuronal tangles…”
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Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations by Mackenzie, Ian R., Arzberger, Thomas, Kremmer, Elisabeth, Troost, Dirk, Lorenzl, Stefan, Mori, Kohji, Weng, Shih-Ming, Haass, Christian, Kretzschmar, Hans A., Edbauer, Dieter, Neumann, Manuela

“…Hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of frontotemporal dementia and motor neuron disease. Recently, unconventional…”
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Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion by Tang, Qilin, Gao, Pan, Arzberger, Thomas, Höllerhage, Matthias, Herms, Jochen, Höglinger, Günter, Koeglsperger, Thomas

“…Dopaminergic (DA) cell death in Parkinson’s disease (PD) is associated with the gradual appearance of neuronal protein aggregates termed Lewy bodies (LBs) that…”
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The FTD‐like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism by Kleinberger, Gernot, Brendel, Matthias, Mracsko, Eva, Wefers, Benedikt, Groeneweg, Linda, Xiang, Xianyuan, Focke, Carola, Deußing, Maximilian, Suárez‐Calvet, Marc, Mazaheri, Fargol, Parhizkar, Samira, Pettkus, Nadine, Wurst, Wolfgang, Feederle, Regina, Bartenstein, Peter, Mueggler, Thomas, Arzberger, Thomas, Knuesel, Irene, Rominger, Axel, Haass, Christian

“…Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk for several neurodegenerative diseases including Alzheimer's…”
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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry by Braak, Heiko, Alafuzoff, Irina, Arzberger, Thomas, Kretzschmar, Hans, Del Tredici, Kelly

“…Assessment of Alzheimer's disease (AD)-related neurofibrillary pathology requires a procedure that permits a sufficient differentiation between initial,…”
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C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration by May, Stephanie, Hornburg, Daniel, Schludi, Martin H., Arzberger, Thomas, Rentzsch, Kristin, Schwenk, Benjamin M., Grässer, Friedrich A., Mori, Kohji, Kremmer, Elisabeth, Banzhaf-Strathmann, Julia, Mann, Matthias, Meissner, Felix, Edbauer, Dieter

“…Hexanucleotide repeat expansion in C9orf72 is the most common pathogenic mutation in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar…”
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The phenotypic spectrum of progressive supranuclear palsy: A retrospective multicenter study of 100 definite cases by Respondek, Gesine, Stamelou, Maria, Kurz, Carolin, Ferguson, Leslie W., Rajput, Alexander, Chiu, Wan Zheng, van Swieten, John C., Troakes, Claire, al Sarraj, Safa, Gelpi, Ellen, Gaig, Carles, Tolosa, Eduardo, Oertel, Wolfgang H., Giese, Armin, Roeber, Sigrun, Arzberger, Thomas, Wagenpfeil, Stefan, Höglinger, Günter U.

“…The phenotypic variability of progressive supranuclear palsy (PSP) may account for its frequent misdiagnosis, in particular in early stages of the disease…”
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In situ architecture of neuronal α-Synuclein inclusions by Trinkaus, Victoria A., Riera-Tur, Irene, Martínez-Sánchez, Antonio, Bäuerlein, Felix J. B., Guo, Qiang, Arzberger, Thomas, Baumeister, Wolfgang, Dudanova, Irina, Hipp, Mark S., Hartl, F. Ulrich, Fernández-Busnadiego, Rubén

“…The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. α-Syn inclusions were long…”
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How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy by Grimm, Max‐Joseph, Respondek, Gesine, Stamelou, Maria, Arzberger, Thomas, Ferguson, Leslie, Gelpi, Ellen, Giese, Armin, Grossman, Murray, Irwin, David J., Pantelyat, Alexander, Rajput, Alex, Roeber, Sigrun, Swieten, John C., Troakes, Claire, Antonini, Angelo, Bhatia, Kailash P., Colosimo, Carlo, Eimeren, Thilo, Kassubek, Jan, Levin, Johannes, Meissner, Wassilios G., Nilsson, Christer, Oertel, Wolfgang H., Piot, Ines, Poewe, Werner, Wenning, Gregor K., Boxer, Adam, Golbe, Lawrence I., Josephs, Keith A., Litvan, Irene, Morris, Huw R., Whitwell, Jennifer L., Compta, Yaroslau, Corvol, Jean‐Christophe, Lang, Anthony E., Rowe, James B., Höglinger, Günter U.

“…Background The Movement Disorder Society criteria for progressive supranuclear palsy define diagnostic allocations, stratified by certainty levels and clinical…”
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The relation between tau pathology and granulovacuolar degeneration of neurons by Puladi, Behrus, Dinekov, Maja, Arzberger, Thomas, Taubert, Max, Köhler, Christoph

“…Neurofibrillary tangles arising from aggregated microtubule-associated protein tau occur in aged brains and are hallmarks of neurodegenerative diseases. A…”
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Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3 by Nihei, Yoshihiro, Mori, Kohji, Werner, Georg, Arzberger, Thomas, Zhou, Qihui, Khosravi, Barham, Japtok, Julia, Hermann, Andreas, Sommacal, Andreas, Weber, Markus, Kamp, Frits, Nuscher, Brigitte, Edbauer, Dieter, Haass, Christian

“…Repeat expansion in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Expanded sense and antisense repeat RNA transcripts in…”
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Which ante mortem clinical features predict progressive supranuclear palsy pathology? by Respondek, Gesine, Kurz, Carolin, Arzberger, Thomas, Compta, Yaroslau, Englund, Elisabet, Ferguson, Leslie W., Gelpi, Ellen, Giese, Armin, Irwin, David J., Meissner, Wassilios G., Nilsson, Christer, Pantelyat, Alexander, Rajput, Alex, Swieten, John C., Troakes, Claire, Josephs, Keith A., Lang, Anthony E., Mollenhauer, Brit, Müller, Ulrich, Whitwell, Jennifer L., Antonini, Angelo, Bhatia, Kailash P., Bordelon, Yvette, Corvol, Jean‐Christophe, Colosimo, Carlo, Dodel, Richard, Grossman, Murray, Kassubek, Jan, Krismer, Florian, Levin, Johannes, Lorenzl, Stefan, Morris, Huw, Nestor, Peter, Oertel, Wolfgang H., Rabinovici, Gil D., Rowe, James B., Eimeren, Thilo, Wenning, Gregor K., Boxer, Adam, Golbe, Lawrence I., Litvan, Irene, Stamelou, Maria, Höglinger, Günter U.

“…ABSTRACT Background Progressive supranuclear palsy (PSP) is a neuropathologically defined disease presenting with a broad spectrum of clinical phenotypes…”
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Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing by Schludi, Martin H., May, Stephanie, Grässer, Friedrich A., Rentzsch, Kristin, Kremmer, Elisabeth, Küpper, Clemens, Klopstock, Thomas, Arzberger, Thomas, Edbauer, Dieter

“…A massive expansion of a GGGGCC repeat upstream of the C9orf72 coding region is the most common known cause of amyotrophic lateral sclerosis and frontotemporal…”
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DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex by Gasparoni, Gilles, Bultmann, Sebastian, Lutsik, Pavlo, Kraus, Theo F J, Sordon, Sabrina, Vlcek, Julia, Dietinger, Vanessa, Steinmaurer, Martina, Haider, Melanie, Mulholland, Christopher B, Arzberger, Thomas, Roeber, Sigrun, Riemenschneider, Matthias, Kretzschmar, Hans A, Giese, Armin, Leonhardt, Heinrich, Walter, Jörn

“…Epigenome-wide association studies (EWAS) based on human brain samples allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease…”
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Parkinson's disease: SNCA- , PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrus by Tatura, Roman, Kraus, Theo, Giese, Armin, Arzberger, Thomas, Buchholz, Malte, Höglinger, Günter, Müller, Ulrich

“…Abstract Introduction In order to better understand the role of epigenetic influences in the etiology of Parkinson's disease (PD), we studied the expression of…”
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Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis by Götzl, Julia K., Mori, Kohji, Damme, Markus, Fellerer, Katrin, Tahirovic, Sabina, Kleinberger, Gernot, Janssens, Jonathan, van der Zee, Julie, Lang, Christina M., Kremmer, Elisabeth, Martin, Jean-Jacques, Engelborghs, Sebastiaan, Kretzschmar, Hans A., Arzberger, Thomas, Van Broeckhoven, Christine, Haass, Christian, Capell, Anja

“…Heterozygous loss-of-function mutations in the progranulin ( GRN ) gene and the resulting reduction of GRN levels is a common genetic cause for frontotemporal…”
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Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss by Schludi, Martin H., Becker, Lore, Garrett, Lillian, Gendron, Tania F., Zhou, Qihui, Schreiber, Franziska, Popper, Bastian, Dimou, Leda, Strom, Tim M., Winkelmann, Juliane, von Thaden, Anne, Rentzsch, Kristin, May, Stephanie, Michaelsen, Meike, Schwenk, Benjamin M., Tan, Jing, Schoser, Benedikt, Dieterich, Marianne, Petrucelli, Leonard, Hölter, Sabine M., Wurst, Wolfgang, Fuchs, Helmut, Gailus-Durner, Valerie, de Angelis, Martin Hrabe, Klopstock, Thomas, Arzberger, Thomas, Edbauer, Dieter

“…Translation of the expanded (ggggcc) n repeat in C9orf72 patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) causes abundant…”
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PERK activation mitigates tau pathology in vitro and in vivo by Bruch, Julius, Xu, Hong, Rösler, Thomas W, De Andrade, Anderson, Kuhn, Peer‐Hendrik, Lichtenthaler, Stefan F, Arzberger, Thomas, Winklhofer, Konstanze F, Müller, Ulrich, Höglinger, Günter U

“…The RNA‐like endoplasmic reticulum kinase (PERK) is genetically associated with the tauopathy progressive supranuclear palsy (PSP). To elucidate the functional…”
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Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model by Zhou, Qihui, Mareljic, Nikola, Michaelsen, Meike, Parhizkar, Samira, Heindl, Steffanie, Nuscher, Brigitte, Farny, Daniel, Czuppa, Mareike, Schludi, Carina, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Feederle, Regina, Roth, Stefan, Haass, Christian, Arzberger, Thomas, Liesz, Arthur, Edbauer, Dieter

“…The C9orf72 repeat expansion is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). Non‐canonical…”
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Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice by Schön, Christian, Hoffmann, Nadine A, Ochs, Simon M, Burgold, Steffen, Filser, Severin, Steinbach, Sonja, Seeliger, Mathias W, Arzberger, Thomas, Goedert, Michel, Kretzschmar, Hans A, Schmidt, Boris, Herms, Jochen

“…Tauopathies are widespread neurodegenerative disorders characterised by the intracellular accumulation of hyperphosphorylated tau. Especially in Alzheimer's…”
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