Search Results - "Aryan, Laila"

The Role of Estrogen Receptors in Cardiovascular Disease by Aryan, Laila, Younessi, David, Zargari, Michael, Banerjee, Somanshu, Agopian, Jacqueline, Rahman, Shadie, Borna, Reza, Ruffenach, Gregoire, Umar, Soban, Eghbali, Mansoureh

“…Cardiovascular Diseases (CVDs) are the leading cause of death globally. More than 17 million people die worldwide from CVD per year. There is considerable…”
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Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs by Aryan, Laila, Medzikovic, Lejla, Umar, Soban, Eghbali, Mansoureh

“…Many crucial cardiovascular adaptations occur in the body during pregnancy to ensure successful gestation. Maladaptation of the cardiovascular system during…”
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Sex Differences in Therapies against Myocardial Ischemia-Reperfusion Injury: From Basic Science to Clinical Perspectives by Medzikovic, Lejla, Azem, Tara, Sun, Wasila, Rejali, Parmis, Esdin, Leana, Rahman, Shadie, Dehghanitafti, Ateyeh, Aryan, Laila, Eghbali, Mansoureh

“…Mortality from myocardial infarction (MI) has declined over recent decades, which could be attributed in large part to improved treatment methods. Early…”
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Estrogen rescues heart failure through estrogen receptor Beta activation by Iorga, Andrea, Umar, Soban, Ruffenach, Gregoire, Aryan, Laila, Li, Jingyuan, Sharma, Salil, Motayagheni, Negar, Nadadur, Rangarajan D, Bopassa, Jean C, Eghbali, Mansoureh

“…Recently, we showed that exogenous treatment with estrogen (E2) rescues pre-existing advanced heart failure (HF) in mice. Since most of the biological actions…”
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Myocardial fibrosis and calcification are attenuated by microRNA-129-5p targeting Asporin and Sox9 in cardiac fibroblasts by Medzikovic, Lejla, Aryan, Laila, Ruffenach, Grégoire, Li, Min, Savalli, Nicoletta, Sun, Wasila, Sarji, Shervin, Hong, Jason, Sharma, Salil, Olcese, Riccardo, Fishbein, Gregory, Eghbali, Mansoureh

“…Myocardial fibrosis and calcification associate with adverse outcomes in nonischemic heart failure. Cardiac fibroblasts (CF) transition into myofibroblasts…”
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Amnion responses to intrauterine inflammation and effects of inhibition of TNF signaling in preterm Rhesus macaque by Presicce, Pietro, Cappelletti, Monica, Morselli, Marco, Ma, Feiyang, Senthamaraikannan, Paranthaman, Protti, Giulia, Nadel, Brian B., Aryan, Laila, Eghbali, Mansoureh, Salwinski, Lukasz, Pithia, Neema, De Franco, Emily, Miller, Lisa A., Pellegrini, Matteo, Jobe, Alan H., Chougnet, Claire A., Kallapur, Suhas G.

“…Intrauterine infection/inflammation (IUI) is a frequent complication of pregnancy leading to preterm labor and fetal inflammation. How inflammation is…”
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Connecting sex differences, estrogen signaling, and microRNAs in cardiac fibrosis by Medzikovic, Lejla, Aryan, Laila, Eghbali, Mansoureh

“…Sex differences are evident in the pathophysiology of heart failure (HF). Progression of HF is promoted by cardiac fibrosis and no fibrosis-specific therapies…”
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HNRNPA2B1: RNA-Binding Protein That Orchestrates Smooth Muscle Cell Phenotype in Pulmonary Arterial Hypertension by Ruffenach, Grégoire, Medzikovic, Lejla, Aryan, Laila, Li, Min, Eghbali, Mansoureh

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Abstract P3004: Small Leucine-Rich Proteoglycan Asporin Represses Smooth Muscle Cell Proliferation And Regulates Pulmonary Hypertension Development by Medzikovic, Lejla, Ruffenach, Gregoire, HONG, JASON, Aryan, Laila, Eghbali, Mansoureh

“…Pulmonary arterial hypertension (PAH) is a devastating pulmonary vascular lung disease characterized by increased pressure in the pulmonary arteries leading to…”
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Abstract P3001: Hnrnpa2b1 An Rna-binding Protein That Orchestrates Smooth Muscle Cell Phenotype In Pulmonary Arterial Hypertension by Ruffenach, Gregoire, Medzikovic, Lejla, Aryan, Laila, Li, Min, Eghbali, Mansoureh

“…BackgroundRNA-binding proteins (RPBs) are master orchestrators of gene expression regulation. RBPs regulate hundreds of transcripts at once by recognizing…”
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HNRNPA2B1: RNA-Binding Protein That Orchestrates Smooth Muscle Cell Phenotype in Pulmonary Arterial Hypertension by Ruffenach, Grégoire, Medzikovic, Lejla, Aryan, Laila, Li, Min, Eghbali, Mansoureh

“…RNA-binding proteins are master orchestrators of gene expression regulation. They regulate hundreds of transcripts at once by recognizing specific motifs…”
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An Investigation into the Role of MicroRNAs in Myocardial Ischemia-reperfusion Injury in Late Pregnancy by Aryan, Laila

“…Maternal mortality remains high in the US and pregnancy-associated myocardial infarction accounts for over 20% of maternal cardiac deaths. The relative risk of…”
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Abstract 415: Asporin Contributes to Reactive Interstitial Cardiac Fibrosis by Regulating Cardiac Fibroblast Activation by Medzikovic, Lejla, Aryan, Laila, Ruffenach, Gregoire, Eghbali, Mansoureh

“…Abstract only Cardiac fibrosis critically contributes to heart failure progression. Depending on the pathological insult, cardiac fibrosis either replaces…”
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Abstract 4144559: Sex Differences in Vascular Remodeling in Pulmonary Hypertension are mediated by Endothelin-2 by Medzikovic, Lejla, Cunningham, Christine, li, min, Aryan, Laila, Sun, Wasila, Dehghanitafti, ateyeh, Ruffenach, Gregoire, Hong, Jason, Eghbali, Mansoureh

“…Abstract only Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial vascular remodelingleading to increased pulmonary artery pressure…”
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Y-Chromosome Gene, Uty , Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines by Cunningham, Christine M, Li, Min, Ruffenach, Gregoire, Doshi, Mitali, Aryan, Laila, Hong, Jason, Park, John, Hrncir, Haley, Medzikovic, Lejla, Umar, Soban, Arnold, Arthur P, Eghbali, Mansoureh

“…Idiopathic pulmonary arterial hypertension (PAH) is a terminal pulmonary vascular disease characterized by increased pressure, right ventricular failure, and…”
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Abstract 12920: Mir98 Regulates Myocardial Ischemia-Reperfusion Injury in Late Pregnancy by Targeting Stat3 and Pgc-1α by Aryan, Laila, Medzikovic, Lejla, Ruffenach, Gregoire, Li, Min, Rahman, Shadie, Esdin, Leana, Bastanhagh, Ehsan, Sun, Wasila, Eghbali, Mansoureh

“…INTRODUCTIONWe have shown that the late-pregnant (LP) rodent is more vulnerable to myocardial ischemia-reperfusion injury (IRI) compared to non-pregnant (NP)…”
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Abstract 13329: Intralipid Protects the Heart in Late Pregnancy Against Ischemia/Reperfusion Injury via Inducing Mir122 by Targeting Pkm2 by Aryan, Laila, Medzikovic, Lejla, Li, Min, Ruffenach, Gregoire, Rahman, Shadie, Bastanhagh, Ehsan, Esdin, Leana, Sun, Wasila, Eghbali, Mansoureh

“…INTRODUCTIONWe have shown hearts of late-pregnant (LP) rats have higher vulnerability to ischemia-reperfusion injury (IRI) compared to non-pregnant (NP) rats,…”
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Abstract 18622: The Role of MicroRNA-98 in the Context of Myocardial Ischemia-Reperfusion Injury During Late Pregnancy by Aryan, Laila, Medzikovic, Lejla, Li, Min, Ruffenach, Gregoire, Rahman, Shadie, Esdin, Leana, Bastanhagh, Ehsan, Sun, Wasila, Afshar, Yalda A, Eghbali, Mansoureh

“…Abstract only BACKGROUND: We have shown that the late-pregnant (LP) rodent exhibits a higher susceptibility to myocardial ischemia-reperfusion injury (IRI)…”
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Abstract P2126: Role Of Microrna-98 In Myocardial Ischemia-reperfusion Injury In Late Pregnancy by Aryan, Laila, Medzikovic, Lejla, Li, Min, Ruffenach, Gregoire, Rahman, Shadie, Bastanhagh, Ehsan, Esdin, Leana, Sun, Wasila, Afshar, Yalda A, Eghbali, Mansoureh

“…Abstract only Background: We have shown that the late-pregnant (LP) rodent is more vulnerable to myocardial ischemia-reperfusion injury (IRI) compared to…”
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Abstract P475: Microrna-129-5p Rescues Myocardial Fibrosis And Calcification By Targeting Asporin And Sox9 In Cardiac Fibroblasts by Medzikovic, Lejla, Aryan, Laila, Ruffenach, Gregoire, Li, Min, Savalli, Nicoletta, Olcese, Riccardo, HONG, JASON, Sharma, Salil, Fishbein, Gregory, Eghbali, Mansoureh

“…Myocardial fibrosis promotes heart failure (HF) progression by impairing myocardial compliance, but also may predispose to myocardial calcification, further…”
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