Search Results - "Aryal, Neeraj K."

Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity by Pant, Vinod, Xiong, Shunbin, Wasylishen, Amanda R., Larsson, Connie A., Aryal, Neeraj K., Chau, Gilda, Tailor, Ramesh C., Lozano, Guillermina

“…Gastrointestinal (GI) syndrome is a serious side effect and doselimiting toxicity observed in patients undergoing lower-abdominal radiotherapy. Previous mouse…”
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Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo by Wasylishen, Amanda R, Sun, Chang, Moyer, Sydney M, Qi, Yuan, Chau, Gilda P, Aryal, Neeraj K, McAllister, Florencia, Kim, Michael P, Barton, Michelle C, Estrella, Jeannelyn S, Su, Xiaoping, Lozano, Guillermina

“…Tumor sequencing studies have emphasized the role of epigenetics and altered chromatin homeostasis in cancer. Mutations in , which encodes a chaperone for the…”
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CRISPR/Cas9 can mediate high-efficiency off-target mutations in mice in vivo by Aryal, Neeraj K, Wasylishen, Amanda R, Lozano, Guillermina

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Genotyping Genetically Modified (GM) Mice by Aryal, Neeraj K, Parker-Thornburg, Jan

“…Prior to generating a new mouse model, it is important to plan the method that will be used to detect which of the mice generated have the mutation(s) desired…”
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Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo by Pant, Vinod, Aryal, Neeraj K, Xiong, Shunbin, Chau, Gilda P, Fowlkes, Natalie W, Lozano, Guillermina

“…Murine double minute 2 (Mdm2) is the principal E3-ubiquitin ligase for p53 and contains a C2H2C4 type RING domain wherein the last cysteine residue is followed…”
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SETD1B mutations confer apoptosis resistance and BCL2 independence in B cell lymphoma by Portelinha, Ana, Wang, Shenqiu, Parsa, Sara, Jiang, Man, Gorelick, Alexander N, Mohanty, Sagarajit, Sharma, Soumya, de Stanchina, Elisa, Berishaj, Marjan, Zhao, Chunying, Heward, James, Aryal, Neeraj K, Tavana, Omid, Wen, Jiayu, Fitzgibbon, Jude, Dogan, Ahmet, Younes, Anas, Melnick, Ari M, Wendel, Hans-Guido

“…The translocation t(14;18) activates BCL2 and is considered the initiating genetic lesion in most follicular lymphomas (FL). Surprisingly, FL patients fail to…”
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The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis by Xiong, Shunbin, Pant, Vinod, Zhang, Yun, Aryal, Neeraj K, You, M James, Kusewitt, Donna, Lozano, Guillermina

“…The p53 inhibitor Mdm4 is present at high levels in multiple human cancers. Overexpression of Mdm4 in mice drives the spontaneous development of mostly…”
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Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo by Aryal, Neeraj K., Pant, Vinod, Wasylishen, Amanda R., Parker-Thornburg, Jan, Baseler, Laura, El-Naggar, Adel K., Liu, Bin, Kalia, Awdhesh, Lozano, Guillermina, Arur, Swathi

“…DICER1 gene alterations and decreased expression are associated with developmental disorders and diseases in humans. Oscillation of Dicer1 phosphorylation and…”
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Dicer1 Phosphomimetic Promotes Tumor Progression and Dissemination by Aryal, Neeraj K, Pant, Vinod, Wasylishen, Amanda R, Rimel, Bobbie J, Baseler, Laura, El-Naggar, Adel K, Mutch, David G, Goodfellow, Paul J, Arur, Swathi, Lozano, Guillermina

“…functions as a tumor suppressor in mouse models. In humans, somatic mutations are associated with many cancers in adults, and patients with DICER1 syndrome…”
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Loss of digestive organ expansion factor ( Diexf) reveals an essential role during murine embryonic development that is independent of p53 by Aryal, Neeraj K, Wasylishen, Amanda R, Pant, Vinod, Riley-Croce, Maurisa, Lozano, Guillermina

“…Increased levels of inhibitors of the p53 tumor suppressor such as Mdm2 and Mdm4 drive tumor development and thus serve as targets for therapeutic…”
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Abstract A19: Phosphorylation results in nuclear translocation of Dicer protein that increases metabolism, accelerates aging, and alters tumorigenesis by Aryal, Neeraj K., Arur, Swathi, Lozano, Guillermina

“…Abstract Dicer is a well-conserved and essential gene that is required for the production of micro RNAs that play key roles during development and cancer…”
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Elongator Complex Regulates MCL1 Dependency Via IRE1-XBP1 Axis of the ER Stress Response Pathway in Multiple Myeloma by Aryal, Neeraj K, Sundarrajan, Anjana, Boiko, Scott, Jenkins, David, Liu, Huayang, Ahdesmaki, Miika, Bornot, Aurelie, Jarnuczak, Andrew, Miele, Eric, McDermott, Ultan, Fawell, Stephen, Drew, Lisa, Boise, Larry H., Cidado, Justin

“…Evasion of apoptosis is a hallmark of cancer wherein overexpression and amplification of pro-survival BCL2-family genes like MCL1 is a common observation. MCL1…”
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Dicer1 phospho-mimetic promotes tumor progression and dissemination by Aryal, Neeraj K, Pant, Vinod, Wasylishen, Amanda R., Rimel, Bobbie, Baseler, Laura, El-Naggar, Adel K., Mutch, David G., Goodfellow, Paul J, Arur, Swathi, Lozano, Guillermina

“…Dicer1 functions as a tumor suppressor in mouse models. In humans, somatic mutations are associated with many cancers in adults and DICER1 syndrome patients…”
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The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumorigenesis by Xiong, Shunbin, Pant, Vinod, Zhang, Yun, Aryal, Neeraj K, You, M. James, Kusewitt, Donna, Lozano, Guillermina

“…The p53 inhibitor Mdm4 is present at high levels in multiple human cancers. Overexpression of Mdm4 in mice drives spontaneous development of mostly lymphomas…”
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