Search Results - "Arwon, Uthai"

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target by Yuthavong, Yongyuth, Tarnchompoo, Bongkoch, Vilaivan, Tirayut, Chitnumsub, Penchit, Kamchonwongpaisan, Sumalee, Charman, Susan A., McLennan, Danielle N., White, Karen L., Vivas, Livia, Bongard, Emily, Thongphanchang, Chawanee, Taweechai, Supannee, Vanichtanankul, Jarunee, Rattanajak, Roonglawan, Arwon, Uthai, Fantauzzi, Pascal, Yuvaniyama, Jirundon, Charman, William N., Matthews, David

“…Malarial dihydrofolate reductase (DHFR) is the target of antifolate antimalarial drugs such as pyrimethamine and cycloguanil, the clinical efficacy of which…”
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Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities by Kamchonwongpaisan, Sumalee, Charoensetakul, Netnapa, Srisuwannaket, Choladda, Taweechai, Supannee, Rattanajak, Roonglawan, Vanichtanankul, Jarunee, Vitsupakorn, Danoo, Arwon, Uthai, Thongpanchang, Chawanee, Tarnchompoo, Bongkoch, Vilaivan, Tirayut, Yuthavong, Yongyuth

“…A series of flexible diaminodihydrotriazines or cycloguanil (Cyc) analogues are developed and shown to inhibit P. falciparum dihydrofolate reductase (PfDHFR)…”
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Flexible 2,4-diaminopyrimidine bearing a butyrolactone as Plasmodium falciparum dihydrofolate reductase inhibitors by Decharuangsilp, Sasithorn, Arwon, Uthai, Hoarau, Marie, Vanichtanankul, Jarunee, Saeyang, Thanaya, Jantra, Tararat, Rattanajak, Roonglawan, Thiabma, Ratthiya, Sooksai, Nawarat, Kongkasuriyachai, Darin, Kamchonwongpaisan, Sumalee, Yuthavong, Yongyuth

“…[Display omitted] •Flexible diaminopyrimidine linked benzyl butyrolactone as PfDHFR inhibitors.•Butyrolactone skeleton to replace a carboxyl side chain of…”
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Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance by Tarnchompoo, Bongkoch, Chitnumsub, Penchit, Jaruwat, Aritsara, Shaw, Philip J, Vanichtanankul, Jarunee, Poen, Sinothai, Rattanajak, Roonglawan, Wongsombat, Chayaphat, Tonsomboon, Aunchalee, Decharuangsilp, Sasithorn, Anukunwithaya, Tosapol, Arwon, Uthai, Kamchonwongpaisan, Sumalee, Yuthavong, Yongyuth

“…The S108N mutation of dihydrofolate reductase (DHFR) renders Plasmodium falciparum malaria parasites resistant to pyrimethamine through steric clash with the…”
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