Search Results - "Arvidsson, Per I."

Sulfonimidamides in Medicinal and Agricultural Chemistry by Chinthakindi, Praveen K., Naicker, Tricia, Thota, Niranjan, Govender, Thavendran, Kruger, Hendrik G., Arvidsson, Per I.

“…The synthesis and evaluation of structural analogues and isosteres are of central importance in medicinal and agricultural chemistry. The sulfonamide…”
Get full text

Tetrazolic Acid Functionalized Dihydroindol:  Rational Design of a Highly Selective Cyclopropanation Organocatalyst by Hartikka, Antti, Arvidsson, Per I

“…Herein we wish to report our development of an improved catalyst (S)-(-)-indoline-2-yl-1H-tetrazole (1) for the enantioselective organocatalyzed…”
Get full text

Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin by Saei, Amir Ata, Gullberg, Hjalmar, Sabatier, Pierre, Beusch, Christian M., Johansson, Katarina, Lundgren, Bo, Arvidsson, Per I., Arnér, Elias S.J., Zubarev, Roman A.

“…Chemical proteomics encompasses novel drug target deconvolution methods in which compound modification is not required. Herein we use Thermal Proteome…”
Get full text

Rational design of asymmetric organocatalysts––increased reactivity and solvent scope with a tetrazolic acid by Hartikka, Antti, Arvidsson, Per I

“…The tetrazolic acid function increases the reactivity and solvent scope of the widely used organocatalyst proline, as demonstrated in the direct catalytic…”
Get full text

The effect of N-methylation of amino acids (Ac-X-OMe) on solubility and conformation: a DFT study by Md Abdur Rauf, Shah, Arvidsson, Per I, Albericio, Fernando, Govender, Thavendran, Maguire, Glenn E M, Kruger, Hendrik G, Honarparvar, Bahareh

“…N-Methylation has a significant impact on improving the oral bioavailability, lipophilicity and aqueous solubility of peptide-based lead drug structures. The…”
Get more information

Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate by Carlström, Karl E., Chinthakindi, Praveen K., Espinosa, Belén, Al Nimer, Faiez, Arnér, Elias S. J., Arvidsson, Per I., Piehl, Fredrik, Johansson, Katarina

“…The Nrf2 transcription factor is a key regulator of redox reactions and considered the main target for the multiple sclerosis (MS) drug dimethyl fumarate…”
Get full text

A New Imidazole-Containing Imidazolidinone Catalyst for Organocatalyzed Asymmetric Conjugate Addition of Nitroalkanes to Aldehydes by Hojabri, Leila, Hartikka, Antti, Moghaddam, Firouz Matloubi, Arvidsson, Per I.

“…Herein we report a new organocatalyst for the asymmetric Michael addition of nitroalkanes to α,β‐unsaturated aldehydes. This catalyst incorporates a basic…”
Get full text

The Oxidation of Electron-Rich Arenes Using a H2O2–Proline System by Chetty, Lloyd C., Kruger, Hendrik G., Arvidsson, Per I., Maguire, Glenn E. M., Govender, Thavendran, Naicker, Tricia

“…This study introduces a novel proline-catalyzed oxidation system employing hydrogen peroxide to synthesize quinones from a diverse range of substrates,…”
Get full text

Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy by Borgegård, Tomas, Gustavsson, Susanne, Nilsson, Charlotte, Parpal, Santiago, Klintenberg, Rebecka, Berg, Anna-Lena, Rosqvist, Susanne, Serneels, Lutgarde, Svensson, Samuel, Olsson, Fredrik, Jin, Shaobo, Yan, Hongmei, Wanngren, Johanna, Jureus, Anders, Ridderstad-Wollberg, Anna, Wollberg, Patrik, Stockling, Kenneth, Karlström, Helena, Malmberg, Asa, Lund, Johan, Arvidsson, Per I, De Strooper, Bart, Lendahl, Urban, Lundkvist, Johan

“…γ-Secretase inhibition represents a major therapeutic strategy for lowering amyloid β (Aβ) peptide production in Alzheimer's disease (AD). Progress toward…”
Get full text

Sulfonyl Fluorides (SFs): More Than Click Reagents? by Chinthakindi, Praveen K., Arvidsson, Per I.

“…Sulfonyl fluoride (SF) containing substances are currently attracting enormous attention among practitioners of both chemical biology and synthetic organic…”
Get full text

Improved Synthesis and Isolation of Bedaquiline by Lubanyana, Hlengekile, Arvidsson, Per I, Govender, Thavendran, Kruger, Hendrik G, Naicker, Tricia

“…Bedaquiline (BDQ) is the most critical pharmaceutical in the world for treating multidrug-resistant Mycobacterium tuberculosis. Despite it being highly…”
Get full text

Sulfonimidamides: Synthesis and Applications in Preparative Organic Chemistry by Nandi, Ganesh Chandra, Arvidsson, Per I.

“…During the last one and half decades, chemists within vastly different areas of science have witnessed a rising interest in chemical matters incorporating the…”
Get full text

Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors by Reddy, Nakita, Girdhari, Letisha, Shungube, Mbongeni, Gouws, Arnoldus C, Peters, Byron K, Rajbongshi, Kamal K, Baijnath, Sooraj, Mdanda, Sipho, Ntombela, Thandokuhle, Arumugam, Thilona, Bester, Linda A, Singh, Sanil D, Chuturgoon, Anil, Arvidsson, Per I, Maguire, Glenn E M, Kruger, Hendrik G, Govender, Thavendran, Naicker, Tricia

“…Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes have emerged responsible for conferring resistance to hard-to-treat…”
Get full text

Correction to “Improved Synthesis and Isolation of Bedaquiline” by Lubanyana, Hlengekile, Arvidsson, Per I, Govender, Thavendran, Kruger, Hendrik G, Naicker, Tricia

Get full text

Enantioselective Organocatalyzed Transformations of β‑Ketoesters by Govender, Thavendran, Arvidsson, Per I, Maguire, Glenn E. M, Kruger, Hendrik G, Naicker, Tricia

“…The β-ketoester structural motif continues to intrigue chemists with its electrophilic and nucleophilic sites. Proven to be a valuable tool within organic…”
Get full text

Microwave assisted SPPS of amylin and its toxicity of the pure product to RIN-5F cells by Muthusamy, Karen, Albericio, Fernando, Arvidsson, Per I., Govender, Patrick, Kruger, Hendrik G., Maguire, Glenn E. M., Govender, Thavendran

“…The 37‐amino acid polypeptide islet amyloid polypeptide (IAPP), or amylin, is found as amyloid aggregates in the islets of Langerhans in patients with type II…”
Get full text

A Synthesis of “Dual Warhead” β‑Aryl Ethenesulfonyl Fluorides and One-Pot Reaction to β‑Sultams by Chinthakindi, Praveen K, Govender, Kimberleigh B, Kumar, A. Sanjeeva, Kruger, Hendrik G, Govender, Thavendran, Naicker, Tricia, Arvidsson, Per I

“…Herein, we report an operationally simple, ligand- and additive-free oxidative boron-Heck coupling that is compatible with the ethenesulfonyl fluoride…”
Get full text

Investigating the efficacy of green solvents and solvent-free conditions in hydrogen-bonding mediated organocatalyzed model reactions by Chetty, Lloyd C, Kruger, Hendrik G, Arvidsson, Per I, Naicker, Tricia, Govender, Thavendran

“…In this study, we have delved into various reactions conducted using green solvents or under solvent-free conditions, employing hydrogen bonding…”
Get full text

On-Water Synthesis of Biaryl Sulfonyl Fluorides by Chinthakindi, Praveen K, Kruger, Hendrik G, Govender, Thavendran, Naicker, Tricia, Arvidsson, Per I

“…Herein, we report an efficient, ligand-free, and additive-free Suzuki–Miyaura coupling that is compatible with the aromatic sulfonyl fluoride functional group…”
Get full text

Synthesis of Novel Aryl and Heteroaryl Acyl Sulfonimidamides via Pd-Catalyzed Carbonylation Using a Nongaseous Precursor by Borhade, Sanjay R, Sandström, Anja, Arvidsson, Per I

“…Hitherto unexplored aryl and heteroaryl acyl sulfonimidamides have been prepared through the development of a new Pd-catalyzed carbonylation protocol. This…”
Get full text