Search Results - "Arunachalam, Gnanapragasam"

Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1 by Arunachalam, Gnanapragasam, Samuel, Samson Mathews, Marei, Isra, Ding, Hong, Triggle, Chris R

“…Background and Purpose Endothelial dysfunction can be detected at an early stage in the development of diabetes‐related microvascular disease and is associated…”
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Regulation of SIRT1 in cellular functions: Role of polyphenols by Chung, Sangwoon, Yao, Hongwei, Caito, Samuel, Hwang, Jae-woong, Arunachalam, Gnanapragasam, Rahman, Irfan

“…Sirtuin 1 (SIRT1) is known to deacetylate histones and non-histone proteins including transcription factors thereby regulating metabolism, stress resistance,…”
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The endothelium: influencing vascular smooth muscle in many ways by Triggle, Chris R, Samuel, Samson Mathews, Ravishankar, Shalini, Marei, Isra, Arunachalam, Gnanapragasam, Ding, Hong

“…The endothelium, although only a single layer of cells lining the vascular and lymphatic systems, contributes in multiple ways to vascular homeostasis…”
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Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM by Yao, Hongwei, Arunachalam, Gnanapragasam, Hwang, Jae-woong, Chung, Sangwoon, Sundar, saac K., Kinnula, Vuokko L., Crapo, James D., Rahman, Irfan, Fridovich, Irwin

“…Extracellular superoxide dismutase (ECSOD or SOD3) is highly expressed in lungs and functions as a scavenger of O 2 • − . ECM fragmentation, which can be…”
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Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD by Hwang, Jae-woong, Chung, Sangwoon, Sundar, Isaac K., Yao, Hongwei, Arunachalam, Gnanapragasam, McBurney, Michael W., Rahman, Irfan

“…Autophagy is a fundamental cellular process that eliminates long-lived proteins and damaged organelles through lysosomal degradation pathway. Cigarette smoke…”
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MicroRNA Signature and Cardiovascular Dysfunction by Arunachalam, Gnanapragasam, Upadhyay, Rohit, Ding, Hong, Triggle, Chris R

“…The worldwide increase in the prevalence of obesity and type 2 diabetes and the associated elevated risk of cardiovascular disease (CVD) has emphasized the…”
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Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD by Arunachalam, Gnanapragasam, Sundar, Isaac K, Hwang, Jae-Woong, Yao, Hongwei, Rahman, Irfan

“…Chronic obstructive pulmonary disease is associated with numerous vascular effects including endothelial dysfunction, arterial stiffness and atherogenesis. It…”
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Protective effect of Nardostachys jatamansi on oxidative injury and cellular abnormalities during doxorubicin-induced cardiac damage in rats by Subashini, Rajakannu, Yogeeta, Surinderkumar, Gnanapragasam, Arunachalam, Devaki, Thiruvengadam

“…Nardostachys jatamansi is a medicinally important herb of Indian origin. It has been used for centuries in the Ayurvedic and Unani systems of medicine for the…”
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Attenuation of Abnormalities in the Lipid Metabolism during Experimental Myocardial Infarction Induced by Isoproterenol in Rats: Beneficial Effect of Ferulic Acid and Ascorbic Acid by Yogeeta, Surinder Kumar, Hanumantra, Rao Balaji Raghavendran, Gnanapragasam, Arunachalam, Subramanian, Senthilkumar, Rajakannu, Subhashini, Devaki, Thiruvengadam

“…: The present study aims at evaluating the effect of the combination of ferulic acid and ascorbic acid on isoproterenol‐induced abnormalities in lipid…”
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Anticancer activity of silver and copper embedded chitin nanocomposites against human breast cancer (MCF-7) cells by Solairaj, Dhanasekaran, Rameshthangam, Palanivel, Arunachalam, Gnanapragasam

“…[Display omitted] Chitin is a natural biopolymer widely used in biomedical and environmental applications due to its distinctive physical, chemical and…”
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Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs by Marwick, John A, Edirisinghe, Indika, Arunachalam, Gnanapragasam, Stevenson, Christopher S, Macnee, William, Kirkham, Paul A, Rahman, Irfan

“…Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2)-mediated survival signaling is critical to endothelial cell survival, maintenance of the…”
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Protective Efficacy of Nardostachys jatamansi (Rhizomes) on Mitochondrial Respiration and Lysosomal Hydrolases during Doxorubicin Induced Myocardial Injury in Rats by Subashini, Rajakannu, Gnanapragasam, Arunachalam, Senthilkumar, Subramanian, Yogeeta, Surinder Kumar, Devaki, Thiruvenkadam

“…Doxorubicin is highly effective in treatment for several forms of cancer. However, doxorubicin induces a cumulative and dose dependent cardiomyopathy that has…”
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SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol by Arunachalam, Gnanapragasam, Yao, Hongwei, Sundar, Isaac K., Caito, Samuel, Rahman, Irfan

“…Endothelial nitric oxide synthase (eNOS) plays a crucial role in endothelial cell functions. SIRT1, a NAD+-dependent deacetylase, is shown to regulate…”
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Molecular Interplay between microRNA-34a and Sirtuin1 in Hyperglycemia-Mediated Impaired Angiogenesis in Endothelial Cells: Effects of Metformin by Arunachalam, Gnanapragasam, Lakshmanan, Arun Prasath, Samuel, Samson Mathews, Triggle, Chris R, Ding, Hong

“…Impaired angiogenesis is a prominent risk factor that contributes to the development of diabetes-associated cardiovascular disease. MicroRNAs (miRNAs), small…”
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Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death by Samuel, Samson Mathews, Ghosh, Suparna, Majeed, Yasser, Arunachalam, Gnanapragasam, Emara, Mohamed M., Ding, Hong, Triggle, Chris R.

“…[Display omitted] Metformin, the most frequently administered drug for the treatment of type 2 diabetes, is being investigated for its potential in the…”
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microRNA‐34a mediates impaired angiogenesis in diabetes: role of SIRT1 and metformin (1051.2) by Arunachalam, Gnanapragasam, Samuel, Samson, Ghosh, Suparna, Triggle, Christopher, Ding, Hong

“…Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with diabetes mellitus. In particularly, hyperglycemia‐associated…”
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Metformin modulates hyperglycemia‐induced endothelial dysfunction through SIRT1 by Arunachalam, Gnanapragasam, Samuel, Samson M, Ding, Hong, Triggle, Christopher R

“…Abstract only Endothelial dysfunction, detected at an early stage in the development of diabetes‐related microvascular disease, is associated with accelerated…”
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Sodium 4‐phenylbutyrate reverses glucose deprivation‐induced endoplasmic reticulum stress and death signal in cultured mouse microvascular endothelial cells (1051.3) by Samuel, Samson, Arunachalam, Gnanapragasam, Ghosh, Suparna, Emara, Mohamed, Ding, Hong, Triggle, Chris

“…In diabetes mellitus, despite higher than normal levels of blood glucose, deficiencies in signaling mechanisms results in a failure to utilize glucose,…”
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Synergistic effect of palmitate and nicotine treatments in diabetic heart (LB560) by Arunachalam, Gnanapragasam, Samuel, Samson, Ghosh, Suparna, Ding, Hong, Machaca, Khaled, Triggle, Chris

“…Background: Metabolic disorders (hyperglycemia, dyslipidemia, hypertension) contribute to the development and progression of cardiovascular disease in…”
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Anti-Ageing Effects of Metformin on the Vascular Endothelium by Triggle, Chris, Arunachalam, Gnanapragasam, Lakshmanan, Arun, Samuel, Samson, Ghosh, Suparna, Ding, Hong

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