State of the art and the future of microbiome-based biomarkers: a multidisciplinary Delphi consensus

Although microbiome signatures have been identified in various contexts (ie, pathogenesis of non-communicable diseases and treatment response), qualified microbiome-based biomarkers are currently not in use in clinical practice. The Human Microbiome Action consortium initiated a Delphi survey to est...

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Bibliographic Details
Published in:	The Lancet. Microbe p. 100948
Main Authors:	Rodriguez, Julie, Hassani, Zahra, Alves Costa Silva, Carolina, Betsou, Fay, Carraturo, Federica, Fasano, Alessio, Israelsen, Mads, Iyappan, Anandhi, Krag, Aleksander, Metwaly, Amira, Schierwagen, Robert, Trebicka, Jonel, Zwart, Hub, Doré, Joel, Cordaillat-Simmons, Magali, Druart, Celine, Godoy, Yolanda, Bork, Peer, Typas, Nassos, Hazenbrink, Dienty Hendrina Maria Johanna, Zitvogel, Laurence, Derosa, Lisa, Blottière, Hervé, Kriaa, Aicha, Maguin, Emmanuelle, Rhimi, Moez, Veiga, Patrick, Pons, Nicolas, Prost, Pierre-Louis, Jarde, Alexander, Boutron, Isabelle, Ravaud, Philippe, Falk Villesen, Ida, Haller, Dirk, Ross, Paul, O'Toole, Paul, Lavelle, Aonghus, Claesson, Marcus, Joos, Raphaela, Hill, Colin, Shkoporov, Andrey, Loftus, Saba, Boucher, Katy, Arumugam, Manimozhayan, Sarathi, Arjun, Morozova, Vitalina, Segata, Nicola, Asnicar, Francesco, Pinto, Federica
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 04-09-2024 Elsevier
Subjects:	Ecology, environment Health Life Sciences
Online Access:	Get full text
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Summary:	Although microbiome signatures have been identified in various contexts (ie, pathogenesis of non-communicable diseases and treatment response), qualified microbiome-based biomarkers are currently not in use in clinical practice. The Human Microbiome Action consortium initiated a Delphi survey to establish a consensus on the needs, challenges, and limitations in developing qualified microbiome-based biomarkers. The questionnaire was developed by a scientific committee via literature review and expert interviews. To ensure broad applicability of the results, 307 experts were invited to participate; 114 of them responded to the first round of the survey, 93 of whom completed the second and final round as well. The survey highlighted the experts’ confidence in the potential of microbiome-based biomarkers for several indications or pathologies. The paucity of validated analytical methods appears to be the principal factor hindering the qualification of these biomarkers. The survey also showed that clinical implementation of these biomarkers would only be possible if kitted and validated molecular assays with simple interpretation are developed. This initiative serves as a foundation for designing and implementing public-private collaborative projects to overcome the challenges and promote clinical application of microbiome-based biomarkers.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	2666-5247 2666-5247
DOI:	10.1016/j.lanmic.2024.07.011