Search Results - "Arulmani, U"

Canakinumab Reduces The Risk Of Acute Gouty Arthritis Flares During Initiation Of Allopurinol Therapy: Results Of A Double-blind, Randomised Study by Schlesinger, N, Mysler, E, Lin, H, DeMeulenmeester, M, Rovensky, J, Arulmani, U, Balfour, A, Krammer, G, Sallstig, P, So, A

“…In this double-blind, double-dummy, dose-ranging study, 432 patients with gouty arthritis initiating allopurinol therapy were randomised 1:1:1:1:1:1:2 to…”
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Canakinumab Relieves Symptoms of Acute Flares and Improves Health-Related Quality Of Life (HRQoL) in Difficult-To-Treat Gouty Arthritis Patients by Suppressing Inflammation: Results of a Randomized, Dose-Ranging Study by So, A, DeMeulenmeester, M, Yücel, E, Arulmani, U, Richard, D, Murphy, V, Sallstig, P, Schlesinger, N

“…In this 8-week, single-blind, dose-ranging study, patients with acute gouty arthritis flares, unresponsive/intolerant or contraindicated to NSAIDs and/or…”
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Experimental migraine models and their relevance in migraine therapy by Arulmani, U, Gupta, S, VanDenBrink, A Maassen, Centurión, D, Villalón, C M, Saxena, P R

“…Although the understanding of migraine pathophysiology is incomplete, it is now well accepted that this neurovascular syndrome is mainly due to a cranial…”
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237 ASSESSMENT OF SMALL BOWEL SAFETY OF LUMIRACOXIB 100 MG OD COMPARED WITH NAPROXEN 500 MG BID PLUS OMEPRAZOLE OR PLACEBO by Hawkey, C, Ell, C, Simon, B, Albert, J, Keuchel, M, McAlindon, M, Fortun, P, Schumann, S, Hugot, J.-L, Yu, V, Arulmani, U, Krammer, G, Rebuli, R, Toth, E

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Lack of effect of the adenosine A1 receptor agonist, GR79236, on capsaicin-induced CGRP release in anaesthetized pigs by Arulmani, U, Heiligers, J P C, Centurión, D, Garrelds, I M, Villalón, C M, Saxena, P R

“…Migraine is a common neurological disorder that is associated with an increase in plasma calcitonin gene-related peptide (CGRP) levels. CGRP, a potent…”
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Effects of sumatriptan on capsaicin-induced carotid haemodynamic changes and CGRP release in anaesthetized pigs by Arulmani, U, Heiligers, J P C, Garrelds, I M, Sánchez-López, A, Willems, E W, Villalón, C M, Saxena, P R

“…It is suggested that during a migraine attack capsaicin-sensitive trigeminal sensory nerves release calcitonin gene related peptide (CGRP), resulting in…”
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Canakinumab reduces the risk of acute gouty arthritis flares during initiation of allopurinol treatment: results of a double-blind, randomised study by Schlesinger, Naomi, Mysler, Eduardo, Lin, Hsiao-Yi, De Meulemeester, Marc, Rovensky, Jozef, Arulmani, Udayasankar, Balfour, Alison, Krammer, Gerhard, Sallstig, Peter, So, Alexander

“…This study assessed the efficacy and safety of canakinumab, a fully human anti-interleukin 1β monoclonal antibody, for prophylaxis against acute gouty…”
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263 THE EFFICACY OF A SINGLE DOSE OF LUMIRACOXIB 400 MG GIVEN PREEMPTIVELY VERSUS POST-OPERATIVELY AFTER AMBULATORY ARTHROSCOPIC KNEE SURGERY by Grifka, J, Zink, J, Hugot, J, Kreiss, A, Arulmani, U, Yu, V, Krammer, G

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P224 Responder definitions for the ulcerative colitis Patient-Reported Outcomes Signs and Symptoms (UC-PRO/SS) tool using patients with ulcerative colitis treated with etrolizumab by Higgins, P, Matsui, A, DeBusk, K, Pulley, J, Scalori, A, Oh, Y S, Arulmani, U

“…Abstract Background Patient-reported outcomes (PROs) are important for evaluating treatment efficacy; there is a need to define what is a clinically meaningful…”
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P132 Analysis of various central endoscopy reading methodologies in the BERGAMOT exploratory induction cohort evaluating etrolizumab in Crohn’s Disease by Reinisch, W, Mishkin, D S, Oh, Y S, Schreiber, S, Maciuca, R, Jacob, R, Hassanali, A, Arulmani, U, Daperno, M

“…Abstract Background Central reading has become the standard for assessing endoscopic endpoints in Crohn’s disease (CD) trials. However, there is no consensus…”
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P136 Association between histological indices and ulcerative colitis activity measures among patients in the HICKORY (etrolizumab) open-label induction cohort by Peyrin-Biroulet, L, Feagan, B, Pai, R K, Arulmani, U, Boruvka, A, Oh, Y S, Scherl, A, Scalori, A, Arrisi, P, Tole, S, Rubin, D T

“…Abstract Background Cross-sectional studies in UC have shown an association between histological and clinical measures of disease activity, but few…”
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Calcitonin gene-related peptide and its role in migraine pathophysiology by Arulmani, Udayasankar, MaassenVanDenBrink, Antoinette, Villalón, Carlos M., Saxena, Pramod R.

“…Migraine is a common neurological disorder that is associated with an increase in plasma calcitonin gene-related peptide (CGRP) levels. CGRP, a neuropeptide…”
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OP011 Etrolizumab treatment leads to early improvement in symptoms and inflammatory biomarkers in anti-TNF-refractory patients in the open-label induction cohort of the phase 3 HICKORY study by Peyrin-Biroulet, L., Feagan, B.G., Mansfield, J., Rubin, D.T., Arulmani, U., Maciuca, R., Tyrrell, H., Thommes, J., Tole, S.

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P468 Etrolizumab treatment improves histological activity as assessed by the Robarts histopathology index by Feagan, B.G., De Hertogh, G., Peyrin-Biroulet, L., Rubin, D.T., Maciuca, R., McBride, J., Arulmani, U., Scherl, A.

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Less Small-Bowel Injury With Lumiracoxib Compared With Naproxen Plus Omeprazole by Hawkey, Christopher J, Ell, Christian, Simon, Bernd, Albert, Jörg, Keuchel, Martin, McAlindon, Mark, Fortun, Paul, Schumann, Stefan, Bolten, Wolfgang, Shonde, Anthony, Hugot, Jean–Louis, Yu, Vincent, Arulmani, Udayasankar, Krammer, Gerhard, Rebuli, Rosemary, Toth, Ervin

“…Background & Aims: The selective cyclooxygenase-2 inhibitor lumiracoxib has been shown to reduce endoscopically detected ulcers and ulcer complications in the…”
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Metabolic and crystal arthropathies: 112. Rapid Improvement in Health-Related Quality of Life in Gouty Arthritis Patients Treated with Canakinumab (ACZ885) Compared to Triamcinolone Acetonide by So, A., De Meulemeester, M., Pikhlak, A., Yucel, A. E., Bodalia, B., Kerrane, J., Arulmani, U., Richard, D., Stricker, K., Ferreira, A., Murphy, V., Sallstig, P., Schlesinger, N., Lin, H., Nasonov, E., Rovensky, J., Mysler, E., Krammer, G., Balfour, A.

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Genomic and nongenomic effects of aldosterone in the rat heart: why is spironolactone cardioprotective? by Chai, Wenxia, Garrelds, Ingrid M, Arulmani, Udayasankar, Schoemaker, Regien G, Lamers, Jos M J, Danser, A H Jan

“…1 Mineralocorticoid receptor (MR) antagonism with spironolactone reduces mortality in heart failure on top of ACE inhibition. To investigate the underlying…”
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Metabolic and Crystal Arthropathies [70-72]: 70. Single Intramuscular Depot Methylprednisolone Injection: A Convenient, Efficacious and Safe Treatment for Gouty Arthritis in an Inpatient Setting by Ishorari, J., Hassan, N., Dasgupta, B., Gendi, N., So, A., Meulemeester, M. D., Bodalia, B., Shamim, T., Pikhlak, A., Yucel, A. E., Arulmani, U., Richard, D., Murphy, V., Sallstig, P., Schlesinger, N.

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Effects of the CGRP receptor antagonist BIBN4096BS on capsaicin‐induced carotid haemodynamic changes in anaesthetised pigs by Kapoor, Kapil, Arulmani, Udayasankar, Heiligers, Jan P C, Garrelds, Ingrid M, Willems, Edwin W, Doods, Henri, Villalón, Carlos M, Saxena, Pramod R

“…Calcitonin gene‐related peptide (CGRP), a potent vasodilator released from capsaicin‐sensitive trigeminal sensory nerves, seems to be involved in the…”
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Concurrent Oral 1 - Therapy of rheumatic disease: OP4. Effectiveness of Rituximab in Rheumatoid Arthritis: Results from the British Society for Rheumatology Biologics Register (BSRBR) by Soliman, M. M., Ashcroft, D. M., Watson, K. D., Lunt, M., Symmons, D., Hyrich, K. L., Lachmann, H. J., Quartier, P., Hachulla, E., Gattorno, M., Cartwright, R., Kone-Paut, I., Zulian, F., Weisbarth-Riedel, E., Lepore, L., Hoyer, J., Foeldvari, I., Ramos, E., Leslie, K., Krammer, G., Preiss, R., Incera, E., Kuemmerle-Deschner, J. B., Hawkins, P. N., So, A., De Meulemeester, M., Pikhlak, A., Yucel, A. E., Bodalia, B., Kerrane, J., Arulmani, U., Richard, D., Murphy, V., Sallstig, P., Schlesinger, N., Christidis, D., Hassan, N., Mapplebeck, S., Dasgupta, B., Genovese, M. C., Sebba, A., Rubbert-Roth, A., Scali, J., Zilberstein, M., ` Vernon, E., Vollenhoven, R., Choy, E., White-Alao, B., Ibrahim, F., Kowalczyk, A., Gordon, P., Hakim, A., Kitas, G., Isenberg, D., Griffiths, B., Lecky, B., Chakravarty, K., Winer, J., Danko, K., Cooper, R. G., Scott, D. L.

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