Sulfanilamide copper(II) chelates with 2-[(2-hydroxyphenyl-imino)methyl]phenolom and 1-[(2-hydroxyphenylimino)-methyl]naphthalen-2-ol
2-[(2-Hydroxyphenylimino)methyl]phenol (H 2 L 1 ) and 1-[(2-hydroxyphenylimino)methyl]naphthalen-2-ol (H 2 L 2 ) reacted with copper(II) acetate hydrate and sulfanilamide (Sf 1 ), sulfathiazole (Sf 2 ), sulfaethidole (Sf 3 ), sulfadiazine (Sf 4 ), and sulfadimidine (Sf 5 ) in ethanol to give mixed-l...
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| Published in: | Russian journal of general chemistry Vol. 80; no. 7; pp. 1351 - 1354 |
|---|---|
| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Dordrecht
SP MAIK Nauka/Interperiodica
01-07-2010
|
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | 2-[(2-Hydroxyphenylimino)methyl]phenol (H
2
L
1
) and 1-[(2-hydroxyphenylimino)methyl]naphthalen-2-ol (H
2
L
2
) reacted with copper(II) acetate hydrate and sulfanilamide (Sf
1
), sulfathiazole (Sf
2
), sulfaethidole (Sf
3
), sulfadiazine (Sf
4
), and sulfadimidine (Sf
5
) in ethanol to give mixed-ligand copper chelates with the composition Cu(Sf
1–5
)(L
1–2
) ·
n
H
2
O (
n
= 1, 2). All these complexes are monomeric. Salicylaldehyde imines (H
2
L
1
and H
2
L
2
) behave as doubly deprotonated tridentate
O,N,O
ligands, whereas sulfanilamides (Sf
1–5
) are unidentate ligands. Thermolysis of the synthesized complexes includes dehydration at 70–90°C, followed by complete thermal decomposition (290–380°C). The complexes [Cu(Sf
1
)(L
1
)] · 2H
2
O and [Cu(Sf
3
)(L
1
)] · H
2
O at a concentration of 10
−4
M inhibited growth and reproduction of 100% of human myeloid leukemia cells (HL-60). The inhibitory effect was 90 and 75%, respectively, at a concentration of 10
−5
M, whereas no antitumor activity was observed at a concentration of 10
−6
M. |
|---|---|
| ISSN: | 1070-3632 1608-3350 |
| DOI: | 10.1134/S1070363210070224 |