Search Results - "Artola, Marta"

Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics by Kytidou, Kassiani, Artola, Marta, Overkleeft, Herman S, Aerts, Johannes M F G

“…Plants contain numerous glycoconjugates that are metabolized by specific glucosyltransferases and hydrolyzed by specific glycosidases, some also catalyzing…”
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An overview of activity-based probes for glycosidases by Wu, Liang, Armstrong, Zachary, Schröder, Sybrin P, de Boer, Casper, Artola, Marta, Aerts, Johannes MFG, Overkleeft, Herman S, Davies, Gideon J

“…•Glycosidases carry out many essential functions across all domains of life.•Activity-based probes can interrogate complex biological samples for glycosidase…”
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Glycosphingolipids and lysosomal storage disorders as illustrated by gaucher disease by Aerts, Johannes M.F.G., Kuo, Chi-Lin, Lelieveld, Lindsey T., Boer, Daphne E.C., van der Lienden, Martijn J.C., Overkleeft, Herman S., Artola, Marta

“…Glycosphingolipids are important building blocks of the outer leaflet of the cell membrane. They are continuously recycled, involving fragmentation inside…”
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In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity‐based protein profiling by Kuo, Chi‐Lin, Kallemeijn, Wouter W., Lelieveld, Lindsey T., Mirzaian, Mina, Zoutendijk, Iris, Vardi, Ayelet, Futerman, Anthony H., Meijer, Annemarie H., Spaink, Herman P., Overkleeft, Herman S., Aerts, Johannes M.F.G., Artola, Marta

“…Glucocerebrosidase (GBA) is a lysosomal β‐glucosidase‐degrading glucosylceramide. Its deficiency causes Gaucher disease (GD), a common lysosomal storage…”
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Fabry Disease: Molecular Basis, Pathophysiology, Diagnostics and Potential Therapeutic Directions by Kok, Ken, Zwiers, Kimberley C, Boot, Rolf G, Overkleeft, Hermen S, Aerts, Johannes M F G, Artola, Marta

“…Fabry disease (FD) is a lysosomal storage disorder (LSD) characterized by the deficiency of α-galactosidase A (α-GalA) and the consequent accumulation of toxic…”
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6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols by Bannink, Stef, Bila, Kateryna O., van Weperen, Joosje, Ligthart, Nina A.M., Ferraz, Maria J., Boot, Rolf G., van der Vliet, Daan, Boer, Daphne.E.C., Overkleeft, Herman S., Artola, Marta, Aerts, Johannes M.F.G.

“…Gaucher disease (GD) is a lysosomal storage disorder (LSD) resulting from inherited glucocerebrosidase (GBA1) deficiency. GD diagnosis relies on GBA1 activity…”
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Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer by Pérez-Gómez, Eduardo, Andradas, Clara, Blasco-Benito, Sandra, Caffarel, María M, García-Taboada, Elena, Villa-Morales, María, Moreno, Estefanía, Hamann, Sigrid, Martín-Villar, Ester, Flores, Juana M, Wenners, Antonia, Alkatout, Ibrahim, Klapper, Wolfram, Röcken, Christoph, Bronsert, Peter, Stickeler, Elmar, Staebler, Annette, Bauer, Maret, Arnold, Norbert, Soriano, Joaquim, Pérez-Martínez, Manuel, Megías, Diego, Moreno-Bueno, Gema, Ortega-Gutiérrez, Silvia, Artola, Marta, Vázquez-Villa, Henar, Quintanilla, Miguel, Fernández-Piqueras, José, Canela, Enric I, McCormick, Peter J, Guzmán, Manuel, Sánchez, Cristina

“…Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different cancer models. However, the biological role of these receptors…”
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Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish by Lelieveld, Lindsey T., Gerhardt, Sophie, Maas, Saskia, Zwiers, Kimberley C., de Wit, Claire, Beijk, Ernst H., Ferraz, Maria J., Artola, Marta, Meijer, Annemarie H., Tudorache, Christian, Salvatori, Daniela, Boot, Rolf G., Aerts, Johannes M.F.G.

“…In Gaucher disease (GD), the deficiency of glucocerebrosidase causes lysosomal accumulation of glucosylceramide (GlcCer), which is partly converted by acid…”
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Distinguishing the differences in β-glycosylceramidase folds, dynamics, and actions informs therapeutic uses by Ben Bdira, Fredj, Artola, Marta, Overkleeft, Herman S., Ubbink, Marcellus, Aerts, Johannes M.F.G.

“…Glycosyl hydrolases (GHs) are carbohydrate-active enzymes that hydrolyze a specific β-glycosidic bond in glycoconjugate substrates; β-glucosidases degrade…”
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Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish by Artola, Marta, Kuo, Chi-Lin, Lelieveld, Lindsey T, Rowland, Rhianna J, van der Marel, Gijsbert A, Codée, Jeroen D. C, Boot, Rolf G, Davies, Gideon J, Aerts, Johannes M. F. G, Overkleeft, Herman S

“…Gaucher disease is caused by inherited deficiency in glucocerebrosidase (GBA, a retaining β-glucosidase), and deficiency in GBA constitutes the largest known…”
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Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions by Boer, Daphne E., Mirzaian, Mina, Ferraz, Maria J., Zwiers, Kimberley C., Baks, Merel V., Hazeu, Marc D., Ottenhoff, Roelof, Marques, André R.A., Meijer, Rianne, Roos, Jonathan C.P., Cox, Timothy M., Boot, Rolf G., Pannu, Navraj, Overkleeft, Herman S., Artola, Marta, Aerts, Johannes M.

“…Deficiency of glucocerebrosidase (GBA), a lysosomal β-glucosidase, causes Gaucher disease. The enzyme hydrolyzes β-glucosidic substrates and transglucosylates…”
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Role of μ-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish by Lelieveld, Lindsey T., Mirzaian, Mina, Kuo, Chi-Lin, Artola, Marta, Ferraz, Maria J., Peter, Remco E.A., Akiyama, Hisako, Greimel, Peter, van den Berg, Richard J.B.H.N., Overkleeft, Herman S., Boot, Rolf G., Meijer, Annemarie H., Aerts, Johannes M.F.G.

“…μ-glucosidases [GBA1 (glucocerebrosidase) and GBA2] are ubiquitous essential enzymes. Lysosomal GBA1 and cytosol-facing GBA2 degrade glucosylceramide (GlcCer);…”
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Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs by Parker, Christopher G, Kuttruff, Christian A, Galmozzi, Andrea, Jørgensen, Lars, Yeh, Chien-Hung, Hermanson, Daniel J, Wang, Yujia, Artola, Marta, McKerrall, Steven J, Josyln, Christopher M, Nørremark, Bjarne, Dünstl, Georg, Felding, Jakob, Saez, Enrique, Baran, Phil S, Cravatt, Benjamin F

“…The diterpenoid ester ingenol mebutate (IngMeb) is the active ingredient in the topical drug Picato, a first-in-class treatment for the precancerous skin…”
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Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α‑Glucosidase II Inhibitor, Blocks Replication of SARS-CoV‑2 and Other Coronaviruses by Thaler, Melissa, Ofman, Tim P., Kok, Ken, Heming, Jurriaan J. A., Moran, Elisha, Pickles, Isabelle, Leijs, Anouk A., van den Nieuwendijk, Adrianus M. C. H., van den Berg, Richard J. B. H. N., Ruijgrok, Gijs, Armstrong, Zachary, Salgado-Benvindo, Clarisse, Ninaber, Dennis K., Snijder, Eric J., van Boeckel, Constant A. A., Artola, Marta, Davies, Gideon J., Overkleeft, Herman S., van Hemert, Martijn J.

“…The combined inhibition of endoplasmic reticulum (ER) α-glucosidases I and II has been shown to inhibit replication of a broad range of viruses that rely on ER…”
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1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor by Artola, Marta, Wu, Liang, Ferraz, Maria J, Kuo, Chi-Lin, Raich, Lluís, Breen, Imogen Z, Offen, Wendy A, Codée, Jeroen D. C, van der Marel, Gijsbert A, Rovira, Carme, Aerts, Johannes M. F. G, Davies, Gideon J, Overkleeft, Herman S

“…The essential biological roles played by glycosidases, coupled to the diverse therapeutic benefits of pharmacologically targeting these enzymes, provide…”
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1,6-epi-cyclophellitol cyclosulfamidate is a new superior lysosomal α-glucosidase stabilizer for the treatment of Pompe disease by Artola, Marta, Aerts, Johannes M.F.G.

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cyclophellitol cyclosulfamidate is a new superior lysosomal α-glucosidase stabilizer for the treatment of Pompe disease by Artola, Marta, Aerts, Johannes M.F.G.

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Activity-based probes for functional interrogation of retaining β-glucuronidases by Wu, Liang, Jiang, Jianbing, Jin, Yi, Kallemeijn, Wouter W, Kuo, Chi-Lin, Artola, Marta, Dai, Wei, van Elk, Cas, van Eijk, Marco, van der Marel, Gijsbert A, Codée, Jeroen D C, Florea, Bogdan I, Aerts, Johannes M F G, Overkleeft, Herman S, Davies, Gideon J

“…Synthesis and application of activity-based probes based on cyclophellitol enabled the cellular profiling of β-glucuronidase activity and revealed an…”
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From Mechanism-Based Retaining Glycosidase Inhibitors to Activity-Based Glycosidase Profiling by Artola, Marta, Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Rovira, Carme, Codée, Jeroen D. C., Davies, Gideon J., Overkleeft, Herman S.

“…Activity-based protein profiling (ABPP) is an effective technology for the identification and functional annotation of enzymes in complex biological samples…”
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Synthesis and Biological Evaluation of Deoxycyclophellitols as Human Retaining β-Glucosidase Inhibitors by Radchenko, Yevhenii, Su, Qin, Schröder, Sybrin S, van Gijlswijk, Luke, Artola, Marta, Aerts, Johannes M F G, Codée, Jeroen D C, Overkleeft, Hermen S

“…Cyclophellitol is a potent and selective mechanism-based retaining β-glucosidase inhibitor that has served as a versatile starting point for the development of…”
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