Search Results - "Artin, Erin"

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations by Yen, Katharine, Travins, Jeremy, Wang, Fang, David, Muriel D, Artin, Erin, Straley, Kimberly, Padyana, Anil, Gross, Stefan, DeLaBarre, Byron, Tobin, Erica, Chen, Yue, Nagaraja, Raj, Choe, Sung, Jin, Lei, Konteatis, Zenon, Cianchetta, Giovanni, Saunders, Jeffrey O, Salituro, Francesco G, Quivoron, Cyril, Opolon, Paule, Bawa, Olivia, Saada, Véronique, Paci, Angelo, Broutin, Sophie, Bernard, Olivier A, de Botton, Stéphane, Marteyn, Benoît S, Pilichowska, Monika, Xu, YingXia, Fang, Cheng, Jiang, Fan, Wei, Wentao, Jin, Shengfang, Silverman, Lee, Liu, Wei, Yang, Hua, Dang, Lenny, Dorsch, Marion, Penard-Lacronique, Virginie, Biller, Scott A, Su, Shin-San Michael

“…Somatic gain-of-function mutations in isocitrate dehydrogenases ( ) 1 and 2 are found in multiple hematologic and solid tumors, leading to accumulation of the…”
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Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers by Popovici-Muller, Janeta, Lemieux, René M, Artin, Erin, Saunders, Jeffrey O, Salituro, Francesco G, Travins, Jeremy, Cianchetta, Giovanni, Cai, Zhenwei, Zhou, Ding, Cui, Dawei, Chen, Ping, Straley, Kimberly, Tobin, Erica, Wang, Fang, David, Muriel D, Penard-Lacronique, Virginie, Quivoron, Cyril, Saada, Véronique, de Botton, Stéphane, Gross, Stefan, Dang, Lenny, Yang, Hua, Utley, Luke, Chen, Yue, Kim, Hyeryun, Jin, Shengfang, Gu, Zhiwei, Yao, Gui, Luo, Zhiyong, Lv, Xiaobing, Fang, Cheng, Yan, Liping, Olaharski, Andrew, Silverman, Lee, Biller, Scott, Su, Shin-San M, Yen, Katharine

“…Somatic point mutations at a key arginine residue (R132) within the active site of the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) confer a novel gain…”
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Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma by Konteatis, Zenon, Artin, Erin, Nicolay, Brandon, Straley, Kimberly, Padyana, Anil K, Jin, Lei, Chen, Yue, Narayaraswamy, Rohini, Tong, Shuilong, Wang, Feng, Zhou, Ding, Cui, Dawei, Cai, Zhenwei, Luo, Zhiyong, Fang, Cheng, Tang, Huachun, Lv, Xiaobing, Nagaraja, Raj, Yang, Hua, Su, Shin-San M, Sui, Zhihua, Dang, Lenny, Yen, Katharine, Popovici-Muller, Janeta, Codega, Paolo, Campos, Carl, Mellinghoff, Ingo K, Biller, Scott A

“…Inhibitors of mutant isocitrate dehydrogenase (mIDH) 1 and 2 cancer-associated enzymes prevent the accumulation of the oncometabolite d-2-hydroxyglutarate…”
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Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1 by Davis, Mindy I., Gross, Stefan, Shen, Min, Straley, Kimberly S., Pragani, Rajan, Lea, Wendy A., Popovici-Muller, Janeta, DeLaBarre, Byron, Artin, Erin, Thorne, Natasha, Auld, Douglas S., Li, Zhuyin, Dang, Lenny, Boxer, Matthew B., Simeonov, Anton

“…Two mutant forms (R132H and R132C) of isocitrate dehydrogenase 1 (IDH1) have been associated with a number of cancers including glioblastoma and acute myeloid…”
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Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH by Allen, Eric L., Ulanet, Danielle B., Pirman, David, Mahoney, Christopher E., Coco, John, Si, Yaguang, Chen, Ying, Huang, Lingling, Ren, Jinmin, Choe, Sung, Clasquin, Michelle F., Artin, Erin, Fan, Zi Peng, Cianchetta, Giovanni, Murtie, Joshua, Dorsch, Marion, Jin, Shengfang, Smolen, Gromoslaw A.

“…Although aberrant metabolism in tumors has been well described, the identification of cancer subsets with particular metabolic vulnerabilities has remained…”
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Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation by Wang, Fang, Travins, Jeremy, DeLaBarre, Byron, Penard-Lacronique, Virginie, Schalm, Stefanie, Hansen, Erica, Straley, Kimberly, Kernytsky, Andrew, Liu, Wei, Gliser, Camelia, Yang, Hua, Gross, Stefan, Artin, Erin, Saada, Veronique, Mylonas, Elena, Quivoron, Cyril, Popovici-Muller, Janeta, Saunders, Jeffrey O., Salituro, Francesco G., Yan, Shunqi, Murray, Stuart, Wei, Wentao, Gao, Yi, Dang, Lenny, Dorsch, Marion, Agresta, Sam, Schenkein, David P., Biller, Scott A., Su, Shinsan M., de Botton, Stephane, Yen, Katharine E.

“…A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter…”
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Abstract 4910: AI predicts drug response from the genomic features of cells and the kinase activity changes induced by compounds by Janssens, Rens, Rizzolo, Kimberly, Artin, Erin, Wagner, Joel, Riester, Markus, Korn, Joshua, Park, Jisoo

“…Abstract Human protein kinases are playing an important role in various biological activities including tumorigenesis and cancer progression, and for this…”
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Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase by McDonald, Gabrielle, Chubukov, Victor, Coco, John, Truskowski, Kevin, Narayanaswamy, Rohini, Choe, Sung, Steadman, Mya, Artin, Erin, Padyana, Anil K, Jin, Lei, Ronseaux, Sebastien, Locuson, Charles, Fan, Zi-Peng, Erdmann, Tabea, Mann, Alan, Hayes, Sebastian, Fletcher, Mark, Nellore, Kavitha, Rao, Siva Sanjeeva, Subramanya, Hosahalli, Reddy, K Satish, Panigrahi, Sunil K, Antony, Thomas, Gopinath, Sreevalsam, Sui, Zhihua, Nagaraja, Nelamangala, Dang, Lenny, Lenz, Georg, Hurov, Jonathan, Biller, Scott A, Murtie, Josh, Marks, Kevin M, Ulanet, Danielle B

“…Agents targeting metabolic pathways form the backbone of standard oncology treatments, though a better understanding of differential metabolic dependencies…”
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Insight into the Mechanism of Inactivation of Ribonucleotide Reductase by Gemcitabine 5′-Diphosphate in the Presence or Absence of Reductant by Artin, Erin, Wang, Jun, Lohman, Gregory J. S, Yokoyama, Kenichi, Yu, Guixue, Griffin, Robert G, Bar, Galit, Stubbe, JoAnne

“…Gemcitabine 5′-diphosphate (F2CDP) is a potent inhibitor of ribonucleotide reductases (RNRs), enzymes that convert nucleotides (NDPs) to deoxynucleotides and…”
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Abstract B126: AG-881, a brain penetrant, potent, pan-mutant IDH (mIDH) inhibitor for use in mIDH solid and hematologic malignancies by Yen, Katharine, Konteatis, Zenon, Sui, Zhihua, Artin, Erin, Dang, Lenny, Straley, Kimberly, Tobin, Erica, Campos, Carl, Yang, Hua, Nagaraja, Raj, Chen, Yue, Kim, Hyeryun, Gliser, Camelia, Nicolay, Brandon, Olaharski, Andrew, Silverman, Lee, Biller, Scott, Su, Shinsan M., Mellinghoff, Ingo, Popovici-Muller, Janeta

“…Abstract AG-881 is an orally available, brain penetrant, potent, small-molecule inhibitor of isocitrate dehydrogenase (IDH) 1 and IDH2 mutant proteins…”
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Structural Biology of Mutant IDH2 Inhibition by DeLaBarre, Byron, Wang, Fang, Travins, Jeremy, Gross, Stefan, Artin, Erin, Dang, Lenny, Biller, Scott, Yen, Katherine

“…Abstract only A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases- 1 and -2 (IDH1, IDH2)[1]. These…”
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Structure of the Nucleotide Radical Formed during Reaction of CDP/TTP with the E441Q-α2β2 of E. coli Ribonucleotide Reductase by Zipse, Hendrik, Artin, Erin, Wnuk, Stanislaw, Lohman, Gregory J. S, Martino, Debora, Griffin, Robert G, Kacprzak, Sylwia, Kaupp, Martin, Hoffman, Brian, Bennati, Marina, Stubbe, JoAnne, Lees, Nicholas

“…The Escherichia coli ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleotides and requires a diferric-tyrosyl…”
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Structure of the Nucleotide Radical Formed during Reaction of CDP/TTP with the E441Q- alpha 2 beta 2 of E. coli Ribonucleotide Reductase by Zipse, Hendrik, Artin, Erin, Wnuk, Stanislaw, Lohman, Gregory JS, Martino, Debora, Griffin, Robert G, Kacprzak, Sylwia, Kaupp, Martin, Hoffman, Brian, Bennati, Marina, Stubbe, JoAnne, Lees, Nicholas

“…The Escherichia coli ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleotides and requires a diferric-tyrosyl…”
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A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model by Wang, Fang, Travins, Jeremy, Lin, Zhizhong, Si, Yaguang, Chen, Yue, Powe, Josh, Murray, Stuart, Zhu, Dongwei, Artin, Erin, Gross, Stefan, Santiago, Stephanie, Steadman, Mya, Kernytsky, Andrew, Straley, Kimberly, Lu, Chenming, Pop, Ana, Struys, Eduard A., Jansen, Erwin E. W., Salomons, Gajja S., David, Muriel D., Quivoron, Cyril, Penard-Lacronique, Virginie, Regan, Karen S., Liu, Wei, Dang, Lenny, Yang, Hua, Silverman, Lee, Agresta, Samuel, Dorsch, Marion, Biller, Scott, Yen, Katharine, Cang, Yong, Su, Shin-San Michael, Jin, Shengfang

“…D-2-hydroxyglutaric aciduria (D2HGA) type II is a rare neurometabolic disorder caused by germline gain-of-function mutations in isocitrate dehydrogenase 2 (…”
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Structure of the Nitrogen-Centered Radical Formed during Inactivation of E. coli Ribonucleotide Reductase by 2‘-Azido-2‘-deoxyuridine-5‘-diphosphate:  Trapping of the 3‘-Ketonucleotide by Fritscher, Jörg, Artin, Erin, Wnuk, Stanislaw, Bar, Galit, Robblee, John H, Kacprzak, Sylwia, Kaupp, Martin, Griffin, Robert G, Bennati, Marina, Stubbe, JoAnne

“…Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to deoxynucleotides providing the monomeric precursors required for DNA replication and…”
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Structure of the nucleotide radical formed during reaction of CDP/TTP with the E441Q-alpha2beta2 of E. coli ribonucleotide reductase by Zipse, Hendrik, Artin, Erin, Wnuk, Stanislaw, Lohman, Gregory J S, Martino, Debora, Griffin, Robert G, Kacprzak, Sylwia, Kaupp, Martin, Hoffman, Brian, Bennati, Marina, Stubbe, Joanne, Lees, Nicholas

“…The Escherichia coli ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleotides and requires a diferric-tyrosyl…”
Get full text