Search Results - "Arthur, Kenisha"

Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine by Barekatain, Yasaman, Ackroyd, Jeffrey J., Yan, Victoria C., Khadka, Sunada, Wang, Lin, Chen, Ko-Chien, Poral, Anton H., Tran, Theresa, Georgiou, Dimitra K., Arthur, Kenisha, Lin, Yu-Hsi, Satani, Nikunj, Ballato, Elliot S., Behr, Eliot I., deCarvalho, Ana C., Verhaak, Roel G. W., de Groot, John, Huse, Jason T., Asara, John M., Kalluri, Raghu, Muller, Florian L.

“…Homozygous deletion of methylthioadenosine phosphorylase ( MTAP ) in cancers such as glioblastoma represents a potentially targetable vulnerability. Homozygous…”
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An enolase inhibitor for the targeted treatment of ENO1-deleted cancers by Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Yan, Victoria C., Barekatain, Yasaman, Khadka, Sunada, Ackroyd, Jeffrey J., Georgiou, Dimitra K., Pham, Cong-Dat, Arthur, Kenisha, Maxwell, David, Peng, Zhenghong, Leonard, Paul G., Czako, Barbara, Pisaneschi, Federica, Mandal, Pijus, Sun, Yuting, Zielinski, Rafal, Pando, Susana Castro, Wang, Xiaobo, Tran, Theresa, Xu, Quanyu, Wu, Qi, Jiang, Yongying, Kang, Zhijun, Asara, John M., Priebe, Waldemar, Bornmann, William, Marszalek, Joseph R., DePinho, Ronald A., Muller, Florian L.

“…Inhibiting glycolysis remains an aspirational approach for the treatment of cancer. We have previously identified a subset of cancers harbouring homozygous…”
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Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma by Khadka, Sunada, Arthur, Kenisha, Barekatain, Yasaman, Behr, Eliot, Washington, Mykia, Ackroyd, Jeffrey, Crowley, Kaitlyn, Suriyamongkol, Pornpa, Lin, Yu-Hsi, Pham, Cong-Dat, Zielinski, Rafal, Trujillo, Marissa, Galligan, James, Georgiou, Dimitra K, Asara, John, Muller, Florian

“…Reprogramming of metabolic pathways is crucial to satisfy the bioenergetic and biosynthetic demands and maintain the redox status of rapidly proliferating…”
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Robust detection of oncometabolic aberrations by 1H–13C heteronuclear single quantum correlation in intact biological specimens by Barekatain, Yasaman, Yan, Victoria C., Arthur, Kenisha, Ackroyd, Jeffrey J., Khadka, Sunada, De Groot, John, Huse, Jason T., Muller, Florian L.

“…Magnetic resonance (MR) spectroscopy has potential to non-invasively detect metabolites of diagnostic significance for precision oncology. Yet, many…”
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Prodrugs of a 1‑Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of ENO1-Deleted Cancers by Yan, Victoria C., Pham, Cong-Dat, Ballato, Elliot S., Yang, Kristine L., Arthur, Kenisha, Khadka, Sunada, Barekatain, Yasaman, Shrestha, Prakriti, Tran, Theresa, Poral, Anton H., Washington, Mykia, Raghavan, Sudhir, Czako, Barbara, Pisaneschi, Federica, Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Ackroyd, Jeffrey J., Georgiou, Dimitra K., Millward, Steven W., Muller, Florian L.

“…Cancers harboring homozygous deletion of the glycolytic enzyme enolase 1 (ENO1) are selectively vulnerable to inhibition of the paralogous isoform, enolase 2…”
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Aliphatic amines are viable pro-drug moieties in phosphonoamidate drugs by Yan, Victoria C., Pham, Cong-Dat, Arthur, Kenisha, Yang, Kristine L., Muller, Florian L.

“…[Display omitted] Phosphate and phosphonates containing a single PN bond are frequently used pro-drug motifs to improve cell permeability of these otherwise…”
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Abstract 984: Synthesis of mixed, hypoxia-activated phosphoramidate esters for the inhibition of Enolase in ENO1- deleted glioblastoma by Muller, Florian, Yan, Victoria C., Ballato, Elliot S., Yang, Kristine L., Georgiou, Dimitra K., Arthur, Kenisha, Shrestha, Pakriti, Khadka, Sunada, Ackroyd, Jeffrey

“…Abstract Background: Precision oncology is currently restricted to activated oncogenes as drug targets, with tumor suppressor deletions remaining largely…”
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TAMI-62. ANGIOGENESIS INHIBITORS STRONGLY SYNERGIZE WITH THERAPEUTICS TARGETING TUMOR METABOLISM by Khadka, Sunada, Lin, Yu-Hsi, Ackroyd, Jeffrey, Arthur, Kenisha, Barekatain, Yasaman, Poral, Anton, Tran, Theresa, Georgiou, Dimitra, de Groot, John, Huse, Jason, Asara, John, Muller, Florian

“…Abstract Angiogenesis inhibition has become a mainstay of oncology despite having fallen short of its early promise. As originally envisioned, angiogenesis…”
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Abstract 3208: Angiogenesis inhibitors strongly synergize with therapeutics targeting tumor metabolism by Khadka, Sunada, Lin, Yu-Hsi, Ackroyd, Jeffery, Arthur, Kenisha, Barekatain, Yasaman, Poral, Anton, Tran, Theresa, Behr, Eliot, Chen, Yining, Georgiou, Dimitra, Depinho, Ronald, Muller, Florian

“…Abstract Angiogenesis inhibition has become a mainstay of oncology despite having fallen short of its early promise. As originally envisioned, angiogenesis…”
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Comparative Pharmacology of a Bis-Pivaloyloxymethyl Phosphonate Prodrug Inhibitor of Enolase after Oral and Parenteral Administration by Yan, Victoria C., Barekatain, Yasaman, Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Arthur, Kenisha, Georgiou, Dimitra K., Jiang, Yongying, Sun, Yuting, Marszalek, Joseph R., Millward, Steven W., Muller, Florian L.

“…Metabolically labile prodrugs can experience stark differences in catabolism incurred by the chosen route of administration. This is especially true for…”
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Bioreducible Phosphonoamidate Pro-drug Inhibitor of Enolase: Proof of Concept Study by Yan, Victoria C, Yang, Kristine L, Ballato, Elliot S, Khadka, Sunada, Shrestha, Prakriti, Arthur, Kenisha, Georgiou, Dimitra K, Washington, Mykia, Tran, Theresa, Poral, Anton H, Pham, Cong-Dat, Yan, Matthew J, Muller, Florian L

“…Glycolysis inhibition remains aspirational in cancer therapy. We recently described a promising phosphonate inhibitor of enolase for cancers harboring…”
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Robust detection of oncometabolic aberrations by 1 H- 13 C heteronuclear single quantum correlation in intact biological specimens by Barekatain, Yasaman, Yan, Victoria C, Arthur, Kenisha, Ackroyd, Jeffrey J, Khadka, Sunada, De Groot, John, Huse, Jason T, Muller, Florian L

“…Magnetic resonance (MR) spectroscopy has potential to non-invasively detect metabolites of diagnostic significance for precision oncology. Yet, many…”
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Author Correction: An enolase inhibitor for the targeted treatment of ENO1-deleted cancers by Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Yan, Victoria C., Barekatain, Yasaman, Khadka, Sunada, Ackroyd, Jeffrey J., Georgiou, Dimitra K., Pham, Cong-Dat, Arthur, Kenisha, Maxwell, David, Peng, Zhenghong, Leonard, Paul G., Czako, Barbara, Pisaneschi, Federica, Mandal, Pijus, Sun, Yuting, Zielinski, Rafal, Pando, Susana Castro, Wang, Xiaobo, Tran, Theresa, Xu, Quanyu, Wu, Qi, Jiang, Yongying, Kang, Zhijun, Asara, John M., Priebe, Waldemar, Bornmann, William, Marszalek, Joseph R., DePinho, Ronald A., Muller, Florian L.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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