Search Results - "Arthur, JSimon C"

Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1 by Nanda, Sambit K, Lopez-Pelaez, Marta, Arthur, J Simon C, Marchesi, Francesco, Cohen, Philip

“…Polymorphisms in the TNIP1 gene encoding A20-binding inhibitor of NF-κB1 (ABIN1) predispose to lupus and other autoimmune diseases in at least eight human…”
Get full text

Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback by Pattison, Michael J, Mackenzie, Kirsty F, Arthur, J Simon C

“…Macrophages are an important source of cytokines following infection. Stimulation of macrophages with TLR agonists results in the secretion of TNF-α, IL-6, and…”
Get full text

Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice by Pauls, Eduardo, Nanda, Sambit K, Smith, Hilary, Toth, Rachel, Arthur, J Simon C, Cohen, Philip

“…The roles of IL-1R-associated kinase (IRAK)2 and IRAK1 in cytokine production were investigated using immune cells from knock-in mice expressing the…”
Get full text

PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A–SIK–CRTC3 Pathway by MacKenzie, Kirsty F., Clark, Kristopher, Naqvi, Shaista, McGuire, Victoria A., Nöehren, Gesa, Kristariyanto, Yosua, van den Bosch, Mirjam, Mudaliar, Manikhandan, McCarthy, Pierre C., Pattison, Michael J., Pedrioli, Patrick G. A., Barton, Geoff J., Toth, Rachel, Prescott, Alan, Arthur, J. Simon C.

“…Abstract The polarization of macrophages into a regulatory-like phenotype and the production of IL-10 plays an important role in the resolution of…”
Get full text

The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-d-aspartate/extracellular signal-regulated kinase/mitogen- and stress-activated kinase signalling pathway by Chandramohan, Yalini, Droste, Susanne K., Arthur, J. Simon C., Reul, Johannes M. H. M.

“…The hippocampus is involved in learning and memory. Previously, we have shown that the acquisition of the behavioural immobility response after a forced swim…”
Get full text

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity by Nanda, Sambit K, Venigalla, Ram K C, Ordureau, Alban, Patterson-Kane, Janet C, Powell, David W, Toth, Rachel, Arthur, J Simon C, Cohen, Philip

“…The protein ABIN1 possesses a polyubiquitin-binding domain homologous to that present in nuclear factor κB (NF-κB) essential modulator (NEMO), a component of…”
Get full text

RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1 by Park, Jeehye, Al-Ramahi, Ismael, Tan, Qiumin, Mollema, Nissa, Diaz-Garcia, Javier R., Gallego-Flores, Tatiana, Lu, Hsiang-Chih, Lagalwar, Sarita, Duvick, Lisa, Kang, Hyojin, Lee, Yoontae, Jafar-Nejad, Paymaan, Sayegh, Layal S., Richman, Ronald, Liu, Xiuyun, Gao, Yan, Shaw, Chad A., Arthur, J. Simon C., Orr, Harry T., Westbrook, Thomas F., Botas, Juan, Zoghbi, Huda Y.

“…Many neurodegenerative disorders, such as Alzheimer’s, Parkinson’s and polyglutamine diseases, share a common pathogenic mechanism: the abnormal accumulation…”
Get full text

Regulation of miRNA transcription in macrophages in response to Candida albicans by Monk, Claire E, Hutvagner, György, Arthur, J Simon C

“…Macrophages detect pathogens via pattern recognition receptors (PRRs), which trigger several intracellular signaling cascades including the MAPK and NFκB…”
Get full text

Posttranslational Regulation of Tristetraprolin Subcellular Localization and Protein Stability by p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Kinase Pathways by Brook, Matthew, Tchen, Carmen R., Santalucia, Tomas, McIlrath, Joanne, Arthur, J. Simon C., Saklatvala, Jeremy, Clark, Andrew R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

MSK1 regulates homeostatic and experience-dependent synaptic plasticity by Corrêa, Sonia A L, Hunter, Christopher J, Palygin, Oleg, Wauters, Sandrine C, Martin, Kirsty J, McKenzie, Colin, McKelvey, Kim, Morris, Richard G M, Pankratov, Yuriy, Arthur, J Simon C, Frenguelli, Bruno G

“…The ability of neurons to modulate synaptic strength underpins synaptic plasticity, learning and memory, and adaptation to sensory experience. Despite the…”
Get full text

The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways by Watts, Colin, Zaru, Rossana, Ronkina, Natalia, Gaestel, Matthias, Arthur, J Simon C

“…Most dendritic cell (DC) responses to Toll-like receptor (TLR) ligands depend on the activation of mitogen-activated protein kinases (MAPKs), but the…”
Get full text

RIG-I-mediated Activation of p38 MAPK Is Essential for Viral Induction of Interferon and Activation of Dendritic Cells: DEPENDENCE ON TRAF2 AND TAK1 by Mikkelsen, Susie S, Jensen, Søren B, Chiliveru, Srikanth, Melchjorsen, Jesper, Julkunen, Ilkka, Gaestel, Matthias, Arthur, J. Simon C, Flavell, Richard A, Ghosh, Sankar, Paludan, Søren R

“…The innate immune system provides an initial defense system against microbial infections and contributes to the development of adaptive immune response. Type I…”
Get full text

Genetic analysis of specific and redundant roles for p38α and p38β MAPKs during mouse development by Barrantes, Ivan del Barco, Coya, Juan Manuel, Maina, Flavio, Arthur, J. Simon C., Nebreda, Angel R.

“…p38α MAPK is an important regulator of cellular responses induced by external cues, but the elucidation of physiological functions for p38α has been…”
Get full text

Selective kinase inhibitors as tools for neuroscience research by Martin, Kirsty J., Arthur, J. Simon C.

“…Signal transduction cascades, including the MAPK, PI3 kinase, Ca2+ and PKC pathways, play important roles in neurons downstream of multiple signals including…”
Get full text

Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays by Martin, Kirsty J., Shpiro, Natalia, Traynor, Ryan, Elliott, Matthew, Arthur, J. Simon C.

“…Neurotrophins are important mediators of neuronal development, survival and plasticity. They act via binding to Trk receptors, which results in the stimulation…”
Get full text

Correction: Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice by Pauls, Eduardo, Nanda, Sambit K., Smith, Hilary, Toth, Rachel, Arthur, J. Simon C., Cohen, Philip

Get full text

Glutamate induces histone H3 phosphorylation but not acetylation in striatal neurons: role of mitogen‐ and stress‐activated kinase‐1 by Brami‐Cherrier, Karen, Lavaur, Jeremie, Pagès, Christiane, Arthur, J. Simon C., Caboche, Jocelyne

“…Chromatin remodelling is thought to play a key role in gene regulation that underlies long‐term synaptic plasticity and memory formation. The dynamic process…”
Get full text

ERK5 pathway regulates the phosphorylation of tumour suppressor hDlg during mitosis by Iñesta-Vaquera, Francisco A., Campbell, David G., Arthur, J. Simon C., Cuenda, Ana

“…► hDlg is phosphorylated during mitosis in multiple residues. ► Prospho-hDlg is excluded from the midbody during mitosis. ► hDlg is not phosphorylated by p38γ…”
Get full text

Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS by McCoy, Claire E, macdonald, Andrew, Morrice, Nick A, Campbell, David G, Deak, Maria, Toth, Rachel, McIlrath, Joanne, Arthur, J Simon C

“…MSK1 (mitogen- and stress-activated kinase 1) is a dual kinase domain protein that acts downstream of the ERK1/2 (extracellular-signal-regulated kinase 1/2)…”
Get full text

Activation of the Mitogen- and Stress-activated Kinase 1 by Arsenic Trioxide by Kannan-Thulasiraman, Padma, Katsoulidis, Efstratios, Tallman, Martin S., Arthur, J. Simon C., Platanias, Leonidas C.

“…Arsenic trioxide (As2O3) is a potent inducer of apoptosis of leukemic cells in vitro and in vivo, but the precise mechanisms by which it mediates such effects…”
Get full text