Search Results - "Arthritis research & therapy"

Synovitis in osteoarthritis: current understanding with therapeutic implications by Mathiessen, Alexander, Conaghan, Philip G

“…Modern concepts of osteoarthritis (OA) have been forever changed by modern imaging phenotypes demonstrating complex and multi-tissue pathologies involving…”
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Long-term safety of secukinumab in patients with moderate-to-severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis: integrated pooled clinical trial and post-marketing surveillance data by Deodhar, A, Mease, P J, McInnes, I B, Baraliakos, X, Reich, K, Blauvelt, A, Leonardi, C, Porter, B, Das Gupta, A, Widmer, A, Pricop, L, Fox, T

“…Secukinumab, a fully human immunoglobulin G1-kappa monoclonal antibody that directly inhibits interleukin (IL)-17A, has been shown to have robust efficacy in…”
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Safety and efficacy of tofacitinib for up to 9.5 years in the treatment of rheumatoid arthritis: final results of a global, open-label, long-term extension study by Wollenhaupt, Jürgen, Lee, Eun-Bong, Curtis, Jeffrey R, Silverfield, Joel, Terry, Ketti, Soma, Koshika, Mojcik, Chris, DeMasi, Ryan, Strengholt, Sander, Kwok, Kenneth, Lazariciu, Irina, Wang, Lisy, Cohen, Stanley

“…Final data are presented for the ORAL Sequel long-term extension (LTE) study evaluating the safety and efficacy of tofacitinib 5 mg and 10 mg twice daily (BID)…”
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Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis by Chen, Zhuming, Zhong, Huan, Wei, Jinsong, Lin, Sien, Zong, Zhixian, Gong, Fan, Huang, Xinqia, Sun, Jinhui, Li, Peng, Lin, Hao, Wei, Bo, Chu, Jiaqi

“…Osteoarthritis (OA) is an inflammatory disease of the joints that causes progressive disability in the elderly. Reactive oxygen species (ROS) play an important…”
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Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations by McInnes, Iain B, Byers, Nicole L, Higgs, Richard E, Lee, Jonathan, Macias, William L, Na, Songqing, Ortmann, Robert A, Rocha, Guilherme, Rooney, Terence P, Wehrman, Thomas, Zhang, Xin, Zuckerman, Steven H, Taylor, Peter C

“…The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the…”
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The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999-2018 by Liu, Bo, Wang, Jie, Li, Yan-Yan, Li, Kang-Peng, Zhang, Qiang

“…We aimed to explore the relationship between the systemic immune-inflammation index (SII) and rheumatoid arthritis (RA) using NHANES from 1999 to 2018. We…”
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New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis by Li, Heng, Wang, Dan, Yuan, Yongjian, Min, Jikang

“…Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the aged population. Current treatments for OA are largely palliative…”
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Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis by Simon, Teresa A, Thompson, Adam, Gandhi, Kunal K, Hochberg, Marc C, Suissa, Samy

“…Patients with rheumatoid arthritis (RA) are at an increased risk of malignancies compared with the general population. This has raised concerns regarding these…”
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Post-traumatic osteoarthritis following ACL injury by Wang, Li-Juan, Zeng, Ni, Yan, Zhi-Peng, Li, Jie-Ting, Ni, Guo-Xin

“…Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of…”
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Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization by Li, Ran, Zhao, Kunchi, Ruan, Qing, Meng, Chunyang, Yin, Fei

“…Spinal cord ischemia-reperfusion injury (SCIRI) often leads to neurological damage and mortality. In this regard, understanding the pathology of SCIRI and…”
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Efficacy and safety of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (Stempeucel®): preclinical and clinical trial in osteoarthritis of the knee joint by Gupta, Pawan Kumar, Chullikana, Anoop, Rengasamy, Mathiyazhagan, Shetty, Naresh, Pandey, Vivek, Agarwal, Vikas, Wagh, Shrikant Yeshwant, Vellotare, Prasanth Kulapurathu, Damodaran, Devi, Viswanathan, Pachaiyappan, Thej, Charan, Balasubramanian, Sudha, Majumdar, Anish Sen

“…Osteoarthritis (OA) is a common and debilitating chronic degenerative disease of the joints. Currently, cell-based therapy is being explored to address the…”
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Adverse events during oral colchicine use: a systematic review and meta-analysis of randomised controlled trials by Stewart, Sarah, Yang, Kevin Chih Kai, Atkins, Kate, Dalbeth, Nicola, Robinson, Philip C

“…Colchicine is a widely used drug to treat inflammatory diseases. Due to its long historical use in medicine, controlled clinical trials have been small and…”
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The inflammatory response in the regression of lumbar disc herniation by Cunha, Carla, Silva, Ana J, Pereira, Paulo, Vaz, Rui, Gonçalves, Raquel M, Barbosa, Mário A

“…Lumbar disc herniation (LDH) is highly associated with inflammation in the context of low back pain. Currently, inflammation is associated with adverse…”
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High levels of circulating interferons type I, type II and type III associate with distinct clinical features of active systemic lupus erythematosus by Oke, Vilija, Gunnarsson, Iva, Dorschner, Jessica, Eketjäll, Susanna, Zickert, Agneta, Niewold, Timothy B, Svenungsson, Elisabet

“…Interferons (IFNs) are considered to be key molecules in the pathogenesis of systemic lupus erythematosus (SLE). We measured levels of type I, II and III IFNs…”
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Survival and prognosis factors in systemic sclerosis: data of a French multicenter cohort, systematic review, and meta-analysis of the literature by Pokeerbux, M R, Giovannelli, J, Dauchet, L, Mouthon, L, Agard, C, Lega, J C, Allanore, Y, Jego, P, Bienvenu, B, Berthier, S, Mekinian, A, Hachulla, E, Launay, D

“…Data on survival and prognosis factors in incident cohorts are scarce in systemic sclerosis (SStc). To describe survival, standardized mortality ratio (SMR),…”
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Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis by Withrow, Joseph, Murphy, Cameron, Liu, Yutao, Hunter, Monte, Fulzele, Sadanand, Hamrick, Mark W

“…Osteoarthritis (OA) and rheumatoid arthritis (RA) are both debilitating diseases that cause significant morbidity in the US population. Extracellular vesicles…”
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Serum KL-6 levels reflect the severity of interstitial lung disease associated with connective tissue disease by Lee, Jeong Seok, Lee, Eun Young, Ha, You-Jung, Kang, Eun Ha, Lee, Yun Jong, Song, Yeong Wook

“…Biomarkers have been actively investigated to supplement functional and imaging modalities to predict the severity, therapeutic responsiveness, and progression…”
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Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation by Haraden, Collin A, Huebner, Janet L, Hsueh, Ming-Feng, Li, Yi-Ju, Kraus, Virginia Byers

“…To identify a synovial fluid (SF) biomarker profile characteristic of individuals with an inflammatory osteoarthritis (OA) endotype. A total of 48 knees (of 25…”
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Efficacy, safety, and tolerability of secukinumab in patients with active ankylosing spondylitis: a randomized, double-blind phase 3 study, MEASURE 3 by Pavelka, Karel, Kivitz, Alan, Dokoupilova, Eva, Blanco, Ricardo, Maradiaga, Marco, Tahir, Hasan, Pricop, Luminita, Andersson, Mats, Readie, Aimee, Porter, Brian

“…Secukinumab, an anti-interleukin-17A monoclonal antibody, improved the signs and symptoms of ankylosing spondylitis (AS) in two phase 3 studies (MEASURE 1 and…”
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Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis by de Winter, Janneke J, van Mens, Leonieke J, van der Heijde, Désirée, Landewé, Robert, Baeten, Dominique L

“…Peripheral disease (arthritis, enthesitis and dactylitis) and extra-articular disease (uveitis, psoriasis and inflammatory bowel disease) is common in…”
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