Search Results - "Arterburn, Jeffrey B"

International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators by Prossnitz, Eric R, Arterburn, Jeffrey B

“…Estrogens are critical mediators of multiple and diverse physiologic effects throughout the body in both sexes, including the reproductive, cardiovascular,…”
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Estrogen signaling through the transmembrane G protein-coupled receptor GPR30 by Prossnitz, Eric R, Arterburn, Jeffrey B, Smith, Harriet O, Oprea, Tudor I, Sklar, Larry A, Hathaway, Helen J

“…Steroids play an important role in the regulation of normal physiology and the treatment of disease. Steroid receptors have classically been described as…”
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GPR30 Expression Is Required for the Mineralocorticoid Receptor–Independent Rapid Vascular Effects of Aldosterone by Gros, Robert, Ding, Qingming, Sklar, Larry A, Prossnitz, Eric E, Arterburn, Jeffrey B, Chorazyczewski, Jozef, Feldman, Ross D

“…It has been increasingly appreciated that steroids elicit acute vascular effects through rapid, so-called nongenomic signaling pathways. Though aldosterone,…”
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Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling by Revankar, Chetana M, Cimino, Daniel F, Sklar, Larry A, Arterburn, Jeffrey B, Prossnitz, Eric R

“…The steroid hormone estrogen regulates many functionally unrelated processes in numerous tissues. Although it is traditionally thought to control…”
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Obligatory role for GPER in cardiovascular aging and disease by Meyer, Matthias R, Fredette, Natalie C, Daniel, Christoph, Sharma, Geetanjali, Amann, Kerstin, Arterburn, Jeffrey B, Barton, Matthias, Prossnitz, Eric R

“…Pharmacological activation of the heptahelical G protein-coupled estrogen receptor (GPER) by selective ligands counteracts multiple aspects of cardiovascular…”
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The G Protein-Coupled Receptor GPR30 Inhibits Proliferation of Estrogen Receptor-Positive Breast Cancer Cells by ARIAZI, Eric A, BRAILOIU, Eugen, PROSSNITZ, Eric R, DUN, Nae J, JORDAN, V. Craig, YERRUM, Smitha, SHUPP, Heather A, SLIFKER, Michael J, CUNLIFFE, Heather E, BLACK, Michael A, DONATO, Anne L, ARTERBURN, Jeffrey B, OPREA, Tudor I

“…The G protein-coupled receptor GPR30 binds 17beta-estradiol (E(2)) yet differs from classic estrogen receptors (ERalpha and ERbeta). GPR30 can mediate…”
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GPR30: a novel therapeutic target in estrogen-related disease by Prossnitz, Eric R, Sklar, Larry A, Oprea, Tudor I, Arterburn, Jeffrey B

“…Estrogen is a crucial hormone in human physiology that regulates a multitude of biological processes. It is also an important target in many diseases such as…”
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The ins and outs of GPR30: A transmembrane estrogen receptor by Prossnitz, Eric R., Oprea, Tudor I., Sklar, Larry A., Arterburn, Jeffrey B.

“…Estrogen is an important hormone in human physiology. It acts both via transcriptional regulation as well as via modulation of intracellular signaling through…”
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Old Drugs with New Tricks: Efficacy of Fluoroquinolones to Suppress Replication of Flaviviruses by Scroggs, Stacey L P, Andrade, Christy C, Chinnasamy, Ramesh, Azar, Sasha R, Schirtzinger, Erin E, Garcia, Erin I, Arterburn, Jeffrey B, Hanley, Kathryn A, Rossi, Shannan L

“…Repurposing FDA-approved compounds could provide the fastest route to alleviate the burden of disease caused by flaviviruses. In this study, three…”
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G Protein-Coupled Estrogen Receptor-Selective Ligands Modulate Endometrial Tumor Growth by Petrie, Whitney K., Dennis, Megan K., Hu, Chelin, Dai, Donghai D., Arterburn, Jeffrey B., Smith, Harriet O., Hathaway, Helen J., Prossnitz, Eric R.

“…Endometrial carcinoma is the most common cancer of the female reproductive tract. GPER/GPR30 is a 7-transmembrane spanning G protein-coupled receptor that has…”
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Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy by Enoru, Julius O, Yang, Barbara, Krishnamachari, Sesha, Villanueva, Ernesto, DeMaio, William, Watanyar, Adiba, Chinnasamy, Ramesh, Arterburn, Jeffrey B, Perez, Ruth G

“…Parkinson's disease (PD) is a neurodegenerative aging disorder in which postmortem PD brain exhibits neuroinflammation, as well as synucleinopathy-associated…”
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Design and Synthesis of a New Class of Membrane-Permeable Triazaborolopyridinium Fluorescent Probes by Hapuarachchige, Sudath, Montaño, Gilbert, Ramesh, Chinnasamy, Rodriguez, Delany, Henson, Lauren H, Williams, Casey C, Kadavakkollu, Samuel, Johnson, Dennis L, Shuster, Charles B, Arterburn, Jeffrey B

“…A new class of fluorescent triazaborolopyridinium compounds was synthesized from hydrazones of 2-hydrazinylpyridine (HPY) and evaluated as potential dyes for…”
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G Protein-Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications by Arterburn, Jeffrey B, Prossnitz, Eric R

“…The actions of estrogens and related estrogenic molecules are complex and multifaceted in both sexes. A wide array of natural, synthetic, and therapeutic…”
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G protein-coupled estrogen receptor 1-mediated effects in the rat myometrium by Tica, Andrei A, Dun, Erica C, Tica, Oana S, Gao, Xin, Arterburn, Jeffrey B, Brailoiu, G Cristina, Oprea, Tudor I, Brailoiu, Eugen

“…G protein-coupled estrogen receptor 1 (GPER), also named GPR30, has been previously identified in the female reproductive system. In this study, GPER…”
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Synthesis and Characterization of Iodinated Tetrahydroquinolines Targeting the G Protein-Coupled Estrogen Receptor GPR30 by Ramesh, Chinnasamy, Nayak, Tapan K, Burai, Ritwik, Dennis, Megan K, Hathaway, Helen J, Sklar, Larry A, Prossnitz, Eric R, Arterburn, Jeffrey B

“…A series of iodo-substituted tetrahydro-3H-cyclopenta[c]quinolines was synthesized as potential targeted imaging agents for the G protein-coupled estrogen…”
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Bisphenol A Directly Targets Tubulin to Disrupt Spindle Organization in Embryonic and Somatic Cells by George, Olivia, Bryant, Bj K, Chinnasamy, Ramesh, Corona, Cesear, Arterburn, Jeffrey B, Shuster, Charles B

“…There is increasing concern that animal and human reproduction may be adversely affected by exposure to xenoestrogens that activate estrogen receptors. There…”
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Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30 by Burai, Ritwik, Ramesh, Chinnasamy, Nayak, Tapan K, Dennis, Megan K, Bryant, Bj K, Prossnitz, Eric R, Arterburn, Jeffrey B

“…The discovery of the G protein-coupled estrogen receptor GPER (also GPR30) and the resulting development of selective chemical probes have revealed new aspects…”
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Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs by Burai, Ritwik, Ramesh, Chinnasamy, Shorty, Marvin, Curpan, Ramona, Bologa, Cristian, Sklar, Larry A, Oprea, Tudor, Prossnitz, Eric R, Arterburn, Jeffrey B

“…The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(III)-catalyzed aza-Diels-Alder cyclization…”
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Ribavirin Reveals a Lethal Threshold of Allowable Mutation Frequency for Hantaan Virus by CHUNG, Dong-Hoon, YANJIE SUN, PARKER, William B, ARTERBURN, Jeffrey B, BARTOLUCCI, Al, JONSSON, Colleen B

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes by Sharma, Geetanjali, Hu, Chelin, Staquicini, Daniela I, Brigman, Jonathan L, Liu, Meilian, Mauvais-Jarvis, Franck, Pasqualini, Renata, Arap, Wadih, Arterburn, Jeffrey B, Hathaway, Helen J, Prossnitz, Eric R

“…Human obesity has become a global health epidemic, with few safe and effective pharmacological therapies currently available. The systemic loss of ovarian…”
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